A comparison between CLNA and CLA effects on body fat, serum parameters and liver composition

Abstract

The potential of conjugated linoleic acid (CLA) as an anti-obesity molecule for humans is still a matter for debate. Thus, a great deal of scientific work is focussed on the research of new effective molecules without deleterious effects on health. The aim of the present work was to analyse the effects of jacaranda seed oil, rich in a conjugated linolenic acid (CLNA), jacaric acid (cis-8,trans-10,cis-12), on body fat, serum parameters and liver composition in rats, and to compare these effects with those of trans-10,cis-12 CLA. Twenty-six male Wistar rats were divided into three groups fed with high-fat diets, supplemented or not (control group) with 0.5% trans-10,cis-12 CLA (CLA group) or 0.5% jacaric acid (CLNA group) for 7 weeks. No statistical differences in food intake or in final body weight were found. Whereas CLA reduced adipose tissue size, CLNA did not. Both CLA and CLNA significantly reduced non-HDL-cholesterol. In spite of a lack of significant changes in glucose and insulin levels, HOMA-IR index was significantly increased, as well as did non-esterified fatty acid levels in CLNA-fed rats. No changes in liver composition were observed. In conclusion, under our experimental conditions, jacaric acid, unlike CLA, does not show a body-fat lowering effect. Even though it leads to a healthy lipoprotein profile, it impairs insulin function. Consequently, it cannot be proposed as an anti-obesity molecule.

The combination of resveratrol and conjugated linoleic acid is not useful in preventing obesity

“…In this case, epididymal depot was the most sensitive. As in the case of resveratrol, these results confirm our previous results [18,19] and are in good accordance with the vast literature reporting the effects of CLA on body fat accumulation in rodents [14]. The fact that body weight remained unchanged despite a reduction in body fat may be due to the well-known anabolic effect of the cis-9,trans-11 CLA isomer [7,16] present in the CLA mixture.…”

“…In groups CLA and RSV+CLA, an equimolecular mixture of trans-10,cis-12 and cis-9, trans-11 (Clarinol®; Lipid Nutrition, Wormerveer, The Netherlands) was added to the diet to reach 0.5% of the active isomer trans-10,cis-12. These doses were used because previous studies from our laboratory have found them to be effective in preventing body fat accumulation induced by obesogenic diets [15,18,19].…”

Trans–trans Conjugated Linoleic Acid Enriched Soybean Oil Reduces Fatty Liver and Lowers Serum Cholesterol in Obese Zucker Rats

“…Our results are in agreement with other studies that have shown that dietary CLA can lower the serum cholesterol levels [30,37]. This decreased serum cholesterol and LDL levels by CLA rich soybean oil can be due to a possible transcriptional activation of the LDL receptor gene which in turn enhances the uptake of VLDL and LDL cholesterol via hepatic LDL receptors [38].…”

Induction of Apoptotic Cell Death in HL-60 Cells by Jacaranda Seed Oil Derived Fatty Acids

“…In this experiment, we extracted jacaranda seed oil from Jacaranda mimosifolia, which is grown in the southern part of Miyazaki in Japan, because jacaranda seed oil has been reported to contain 32 JA 14 . The levels of JA in the JFA used in this experiment were comparable with previ- Data are mean ± SE of 3 measurements.…”