A comparison between the novel rabbit monoclonal antibodies (SP1 and B644) and mouse antibodies for evaluating estrogen receptor in breast tumors

Rabbit monoclonal E‐cadherin antibody: A cost‐effective alternative to mouse monoclonal antibody in distinguishing ductal carcinoma in situ from lobular carcinoma in situ

“…Many published studies have compared rabbit monoclonal antibodies to their mouse monoclonal counterparts and reported stronger and cleaner staining with the former . Furthermore, in some comparative studies for ER, it was found that the rabbit monoclonal antibodies were not only more sensitive but also better at predicting survival among breast cancer patients . And yet despite its heavy use, there is a dearth of published studies to support the use of a RabMAb against E‐cadherin over its mouse counterpart.…”

Contribuição da imuno-histoquímica na avaliação de fatores prognósticos e preditivos do câncer de mama e no diagnóstico de lesões mamárias

“…Estudos recentes da literatura e de nosso grupo mostram maior sensibilidade dos novos anticorpos monoclonais de coelho para avaliação de receptores hormonais e do HER2 em câncer de mama comparados aos monoclonais de camundongo (19,32,40,41) .O uso dos novos anticorpos de coelho aumenta a detecção de casos positivos para RE e tem melhor correlação com a resposta terapêutica (7) Além dos novos anticorpos de coelho, o uso dos novos sistemas de polímeros não-biotinilados também permite melhor qualidade das reações com menos coloração inespecífica e sem os efeitos da biotina endógena (13) .…”

Anti-Synepthelichorial Placenta Scfv Library Construction

“…The developments of the techniques of molecular biology and genetic engineering have provided the emergence of recombinant DNA technology has enabled the production of several new molecules of immunoglobulin fragments Maranhão [1]. Such biomolecules are important for the development of studies in the fields molecular biology, medicine and pharmaceuticals, and also in developing treatments for various types of diseases and diagnoses Seo et al [2],Lynch et al [3], such as cancer and infectious diseases Baert et al [4]; Rocha et al [5];Bumrela [6]; Huber et al [7],therapies to combat rheumatoid arthritis and osteoarthritis Hughes et al [8], against smoking Bevins et al [9]; Peterson et al [10];fighting drugs like methamphetamine Peterson, et al [10] and cocaine Dickerson &Janda [11]; combating the sequelae of alcoholism Bagasra et al [12]; combating Alzheimer's Boado et al [13]; Nisbetet al [14]; detecting myocardial injury related Marti et al [15]; diagnosis of pregnancy Payne Jr et al [16]. Antibodies resulting from manipulation and recombination of variable fragments single chain (scFv) immunoglobulin, have been used in therapeutics and diagnostics, offering advantages over conventional antibodies Malecki et al [17]; Wilkinson et al [18]; Monnier et al [19].…”