A Comparison of 1 Minimum Alveolar Concentration Desflurane and 1 Minimum Alveolar Concentration Isoflurane Anesthesia in Patients Undergoing Craniotomy for Supratentorial Lesions

Yildiz, Karamehmet; Biçer, Cihangir; Aksu, Recep; Doğru, Kudret; Madenoğlu, Halit; Boyacı, Adem

doi:10.1016/j.curtheres.2011.03.001

Cited by 8 publications

(22 citation statements)

References 22 publications

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“…Of note is the fact that the highest decrease in CPP was observed in the third period of the experiment at over 2/3 MAC while the absolute values of CPP noted then were below 60mmHg, which is considered safe. The available literature contains only a few clinical studies directly assessing the effect of desflurane on CPP [16][17][18]. The findings of the study analysing the effect of 0.5 and 1.0 MAC isoflurane, sevoflurane and desflurane on ICP and CPP in children are comparable with our results.…”

Section: Discussionsupporting

confidence: 81%

Wpływ stopniowo narastających stężeń desfluranu na mózgowe ciśnienie perfuzyjne u królika

Wierzchowska¹,

Kowiański²,

Niewiadomski³

et al. 2018

Anaesthesiol Intensive Ther

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Background: In nearly all cases of general anaesthesia with a volatile agent, the anaesthetic concentration has to be increased. Since the anaesthetic affects both the factors determining intracranial homeostasis and the systemic circulation, it is crucial that cerebral perfusion pressure (CPP) is protected. The aim of the present study was to assess the influence of gradually increased concentrations of desflurane on the cerebral and systemic circulations based on CPP, mean arterial pressure (MAP), intracranial pressure (ICP) and their correlations. Methods: The study was carried out on 25 rabbits of the same gender (male) randomly assigned to two groups: control (n = 10) and group I (n = 15). Over three 15-minute periods, the animals were exposed to increase concentrations of desflurane so as to achieve 1/3, 2/3 and 1 MAC Minimal Alveolar Concentration (3, 6, 9 vol%) of the effective end-tidal concentration of desflurane (Et) at the end of each period, respectively. Conclusions: A decrease in CPP induced by desflurane was associated with a decrease in MAP but not an increase in ICP. The depressive effect of desflurane on the cerebral and systemic circulations is a consequence of its effector site concentration.

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Section: Discussionsupporting

confidence: 81%

Wpływ stopniowo narastających stężeń desfluranu na mózgowe ciśnienie perfuzyjne u królika

Wierzchowska¹,

Kowiański²,

Niewiadomski³

et al. 2018

Anaesthesiol Intensive Ther

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“…The use of desflurane in neuro anaesthesia is controversial as it produces cerebral vasodilation. However some studies confirm that the effects of desflurane on ICP and CBF are similar to isoflurane [3].…”

Section: Introductionmentioning

confidence: 86%

A Comparison of Emergence Characteristics with the use of Isoflurane, Sevoflurane and Desflurane in Patients Undergoing Spinal Surgeries under General Anaesthesia

Gupta¹,

Mongia²,

Jethava³

et al. 2017

IOSR JDMS

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“…Sample size calculation, to achieve 80% power of the study, was on the basis of the previous study investigating the recovery charecteristics of desflurane, which demonstrated the mean time to achieve Aldrete score ≥8 as 9.58 ± 6.13 min. [ 1 ] We determined that 27 patients would be required for each group to detect 80% difference (8 min) in the time taken to achieve an Aldrete score of 9, using α and β values of 0.05 and 0.2. We chose to detect 80% difference as a smaller change would be clinically insignificant.…”

Section: Methodsmentioning

confidence: 99%

“…In neurosurgery, it may facilitate early post-operative neurological assessment. [ 1 2 ] Scalp block can blunt the haemodynamic response to noxious stimuli, decrease the amount of opioids and reduce post-operative pain[ 3 4 ] facilitating smooth and early emergence. Dexmedetomidine provides good perioperative haemodynamic stability, decreases the requirement of intraoperative opioid and has minimal effect on ICP.…”

Section: Introductionmentioning

confidence: 99%

Effects of avoiding neuromuscular blocking agents during maintenance of anaesthesia on recovery characteristics in patients undergoing craniotomy for supratentorial lesions: A randomised controlled study

et al. 2017

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Background and Aims:Neuromuscular blocking agents have been one of the cornerstones of anaesthesia. With the advent of newer surgical, anaesthetic and neurological monitoring techniques, their utility in neuroanaesthesia practice seems dispensable. The aim of this prospective, comparative, randomised study was to determine whether neuromuscular blocking agents are required in patients undergoing supratentorial surgery when balanced anaesthesia with desflurane, dexmedetomidine and scalp block is used.Methods:Sixty patients with the American Society of Anesthesiologists physical status I or II, aged between 18 and 60 years were included in the study. All patients received anaesthesia including desflurane, dexmedetomidine and scalp block. The patients were randomly allocated to receive no neuromuscular blocking agent (Group A) or atracurium infusion to keep train-of-four count 2 (Group B). The two groups were compared with respect to haemodynamic stability, brain relaxation scores and recovery characteristics. Haemodynamic parameters and time taken to achieve Aldrete score >9 and other secondary outcomes were analysed using Student's t-test. Non-parametric data were analysed using the Mann–Whitney test.Results:The mean arterial pressure was comparable between the groups. The intraoperative heart rate was comparable; however, in the post-operative period, it remained higher in Group B for 30 min after extubation (P = 0.02). The brain relaxation scores were comparable among the two groups (P = 0.27). Tracheal extubation time, time taken for orientation and time required to reach Aldrete score ≥9 were comparable among the two groups.Conclusion:The present study suggests that balanced anaesthesia using desflurane, dexmedetomidine and scalp block can preclude the use of neuromuscular blocking agents in patients undergoing supratentorial surgery under intense haemodynamic monitoring.

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A Comparison of 1 Minimum Alveolar Concentration Desflurane and 1 Minimum Alveolar Concentration Isoflurane Anesthesia in Patients Undergoing Craniotomy for Supratentorial Lesions

Cited by 8 publications

References 22 publications

Wpływ stopniowo narastających stężeń desfluranu na mózgowe ciśnienie perfuzyjne u królika

Wpływ stopniowo narastających stężeń desfluranu na mózgowe ciśnienie perfuzyjne u królika

A Comparison of Emergence Characteristics with the use of Isoflurane, Sevoflurane and Desflurane in Patients Undergoing Spinal Surgeries under General Anaesthesia

Effects of avoiding neuromuscular blocking agents during maintenance of anaesthesia on recovery characteristics in patients undergoing craniotomy for supratentorial lesions: A randomised controlled study

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