A Comparison of Analgesic Effect between Loxoprofen and Celecoxib and the Frequency of the Hemorrhage Following Tonsillectomy

Hirai, Takuya; Fukushima, Noriyuki; Miyahara, Nobuyuki; Yoshiga, Ayako; Ariki, Masahiko

doi:10.3950/jibiinkoka.119.1110

Cited by 3 publications

(1 citation statement)

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“…Our results also point to a non-significantly elevated risk of haemorrhage after post-operative celecoxib usage. Celecoxib and traditional NSAIDs were compared in a study by Hirai et al 31 that included 107 tonsillectomy cases. According to their findings, the rate of bleeding and haemorrhage in the celecoxib group was much lower (0.0%) than it was in the loxoprofen group (31.2%).…”

Section: Discussionmentioning

confidence: 99%

Assessing the efficacy of celecoxib after tonsillectomy and/or adenoidectomy: A systematic review and meta‐analysis of randomised control trials

Banatwala,

Syed,

Ain

et al. 2024

Clinical Otolaryngology

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ObjectivesTonsillectomy and adenoidectomy are common surgical procedures that cause persistent pain, bleeding, and functional limitations. We aimed to investigate the efficacy of celecoxib compared with a placebo for managing post‐tonsillectomy or adenoidectomy pain and other adverse events.DesignSystematic review and meta‐analysis.MethodsWe conducted a systematic literature search in the PubMed, Cochrane, and Google Scholar databases from inception until July 2023. Dichotomous outcomes have been reported as risk ratios (RR) while continuous outcomes were reported using mean differences (MD). A funnel plot was drawn to investigate publication bias.ResultsFrom 1394 records identified, 6 randomised double‐blind trials comprising 591 participants undergoing tonsillectomy and/or adenoidectomy were eligible for inclusion. A high dose (400 mg) of celecoxib was effective in decreasing the pain score for ‘worst pain’ after the procedure (MD: −10.98, [95% CI: −11.53, −10.42], p < .01, I2 = 0%) while a low dose (200 mg) was not significantly effective (p = 0.31). For managing other outcomes such as vomiting (RR: 1.37 [95% CI: 0.69, 2.68], p = 0.37, I2 = 67%), diarrhoea (RR: 1.41, [95% CI: 0.75, 2.64], p = .29, I2 = 42%), dizziness/drowsiness (RR: 0.90, [95% CI: 0.71, 1.15], p = .48, I2 = 0%), functional recovery time (p = .74), and headache (p = .91), there was no significant difference between the group on celecoxib and the placebo group regardless of dosage. Finally, there was no significant difference (RR: 1.02, [95% CI: 0.91, 1.15], p = .69, I2 = 0%) in the effect of the intervention on minimum bleeding, moderate bleeding, and profuse bleeding.ConclusionThis meta‐analysis provides robust evidence pooled from high‐quality trials and raises questions about the efficacy of celecoxib for tonsillectomy and/or adenoidectomy, challenging existing perceptions.

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Section: Discussionmentioning

confidence: 99%