A comparison of autogenous bone graft combined with deproteinized bovine bone and autogenous bone graft alone for treatment of alveolar cleft

Management of Failed Alveolar Bone Grafts

“…25 The combination of demineralized bone matrix and allograft bone has been used successfully in pediatric patients without growth abnormalities, but its use thus far has been limited. 4,6,7 Bone morphogenetic protein (recombinant human bone morphogenetic protein-2)-only reconstruction has been used sparingly due to possible adverse inflammatory reactions or growth restrictions in the premature skeleton. 1,5,26,27 A recent study by Francis et al has reported the successful use of bone morphogenetic protein-2 in conjunction with demineralized bone matrix for the repair of alveolar defects.…”

“…[4][5][6][7] Allograft bone grafting of the cleft maxillary and alveolar defect is an attractive alternative to use of an autograft, but safety and efficacy have not been adequately reported. 8 An allograft-only technique, first described by Kraut in 1987, demonstrated successful treatment of alveolar cleft defects using freeze-dried allograft bone marrow, with canine tooth eruption in 80 percent of the cohort.…”

Bone regenerative medicine: classic options, novel strategies, and future directions

“…The former are natural polymers such as collagen type I or DBM [24,62,63]. Porous metals, bioactive glasses, synthetic polymers such as polylactic acid (PLA) and polyglycolic acid (PGA), and calcium phosphate ceramics such as hydroxyapatite (HA) and tricalcium phosphates (TCP) are examples of synthetic materials [2,24,27,32,64].…”

Preparation of Deproteinized Human Bone and Its Mixtures with Bio-Glass and Tricalcium Phosphate - Innovative Bioactive Materials for Skeletal Tissue Regeneration

“…The presence of autogenous bone in the mixture was the basis for the osteoinductive properties of the material and the more favorable biological conditions for bone growth when compared to deproteinized bovine bone alone (Thorwarth et al, 2006). Similarly, more satisfactory clinical results were reported when deproteinized bovine bone was used in combination with autogenous bone in the management of alveoschisis in humans, instead of bone autograft alone (Thuaksuban et al, 2010). Experiments on rabbits have also given interesting results.…”

“…Attempts at bone replacement with materials obtained by combining autogenous bone and deproteinized bovine bone constitute another example of the potential optimization of biological conditions for new skeletal tissue growth within a skeletal defect. The inclusion of autogenous material with osteoinductive properties in such composites results in the enhanced formation of better quality bone Pripatnanont et al, 2009;Thorwarth et al, 2006;Thuaksuban et al, 2010). In vitro cellular studies have confirmed that allogenic materials of human origin (demineralized bone matrix, deproteinized bone) may also have some osteoinductive activity.…”