A comparison of chlormezanone, meprobamate, and placebo

Abstract

Clinical and Research Facilities, Centrallslip State Hospital, and Nassau County Hospital for Pulmonary Diseases, PlainviewIn a previous studyl an attempt was made tD evaluate the antianxiety effects of chlDrmezanone alone and in cDmbinatiDn with aspirin. The results suggested clinical activity which we felt warranted further study in terms Df determining cDmparative efficacy with a standard, widely accepted therapeutic agent. The present study considers the clinical effect of chlormezanDne and meprobamate in a double-blind placebD cDntrolled comparative trial. MethodSixty-seven patients, 41 WDmen (20 tD 77 years DId) and 26 men (18 to 60 years DId) were assigned at randDm to chlormezanDne, meprDbamate, Dr placebD ther-

Effects of acute and repeated doses of two muscle relaxants chlormezanone and thiocolchicoside, on vigilance and psychomotor performance of healthy volunteers

“…It proved to be as effective at the dosage of 800 mg as 40 mg of chlordiazepoxide, while having more marked sedative effects (Rickels et al, 1974). However, other trials have failed to find such marked sedative effects (Kearney, 1960;Friedman et al, 1966;Champlin et al, 1968). Posturography or recording of body sway has been used as a reliable and sensitive measure of the sedative effects of alcohol and psychoactive drugs which were characterised by an increase in body sway: length, area and energies McClelland, 1989).…”