A Comparison of Different Schemes of Neoadjuvant Chemotherapy Followed by Concurrent Chemotherapy and Radiotherapy for Locally Advanced Cervical Cancer: A Retrospective Study

Tian, Xue; Yang, Feiyue; Feng-hu, LI; Ran, Li; Chang, Jianying; Li, Jiehui; Hong, Wei; Lang, Shan; Du, Ye; Hu, Lili; Fan, Min; He, Mingyuan; Li, Yongxia; Wang, Heran; Zuo, Kai; Zhou, Bo; Chen, Shuying; Mao, Wanli

doi:10.2147/cmar.s328309

Cited by 11 publications

(10 citation statements)

References 34 publications

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“…Compared with patients without lymph node metastasis, the five-year survival rate of cases with metastasis greatly reduces, and the recurrence rate significantly increases. The five-year survival rate of patients with cervical cancer decreases with increasing number of metastatic lymph nodes [14]. Therefore, determining the lymph node metastasis in patients with cervical cancer before treatment is of great significance to the selection of an appropriate treatment plan and prognostic evaluation.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of dynamic enhanced multi-slice spiral CT in lymph node metastasis of cervical cancer and analysis of the causes of missed diagnosis

2024

EJGO

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We aimed to explore the diagnostic value of multi-slice spiral computed tomography dynamic enhanced scanning (MSCT) for the lymph node metastasis of cervical cancer and the causes for missed diagnosis. A total of 283 patients with cervical cancer treated from March 2019 to March 2022 were selected. Lymph node metastasis was observed by MSCT. The results were compared with those of surgical and pathological examinations to analyze the diagnostic value of MSCT. The patients with confirmed lymph node metastasis were divided into a missed diagnosis group (n = 41) and a nonmissed diagnosis group (n = 128). The factors for missed diagnosis by MSCT were explored by multivariate logistic regression analysis. A back propagation (BP) neural network model was constructed and evaluated. Results: The positive coincidence rate of MSCT diagnosis was 92.75%, the negative coincidence rate was 71.72%, and the total coincidence rate was 81.98%. The area under the receiver operator characteristic curve of MSCT was 0.741 (95% confidence interval: 0.723-0.826), indicating a high diagnostic value. A high degree of differentiation, negative Ki-67 expression, and interstitial infiltration depth of

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Section: Discussionmentioning

confidence: 99%

Diagnostic value of dynamic enhanced multi-slice spiral CT in lymph node metastasis of cervical cancer and analysis of the causes of missed diagnosis

2024

EJGO

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“…[37] However, cancer treatment entails cytotoxicity, whether by chemotherapy or radiotherapy, leading to the destruction of tumor cells and adversely affecting normal bodily functions, resulting in various severity levels of side effects that significantly impact treatment compliance and overall quality of life. [38] According to TCM theory, radiotherapy and chemotherapy may cause excessive heat toxicity, depletion of jin fluid, disharmony between yin and yang, disturbances in qi and blood circulation, and dysfunction of viscera and meridians. [39] Xihuang Pills/Capsules function by stimulating blood circulation, resolving stasis, promoting orifice opening, detoxifying, softening hardness, and dispersing nodules.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of the efficacy and safety of Xihuang Pills/capsules in adjuvant treatment of uterine cervical neoplasms

Xu,

Tian,

et al. 2023

Medicine

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Background: Xihuang Pills/Capsules have a longstanding history of utilization in traditional Chinese medicine (TCM) for treating cancer. Nevertheless, a comprehensive investigation is required regarding the specific impacts and safety of Xihuang Pills/Capsules in individuals with uterine cervical neoplasms. Thus, conducting a meta-analysis is essential to evaluate the clinical effectiveness of combining Xihuang Pills/Capsules with Western medicine in patients with cervical neoplasms. Methods: The research involved searching 5 English and 4 Chinese databases for randomized controlled trials (RCTs) investigating the use of Xihuang Pills/Capsules in conjunction with Western medicine for treating uterine cervical neoplasms. Subsequently, statistical analysis was carried out using Review Manager software (version 5.3). Results: This research encompassed 10 RCTs involving 937 patients. The findings revealed that the combination of Xihuang Pills/Capsules with Western medicine treatment led to improvements in various aspects of the patients’ condition. Specifically, there was an enhancement in the short-term efficacy rate (risk ratio [RR] = 1.14, 95% confidence interval [CI]: 1.06–1.22, P = .0003), Karnofsky performance score (KPS) (mean difference [MD] = 5.90, 95% CI: 0.54–11.26, P = .03), survival rates, CD3+, CD3 + CD4+, CD3 + CD8+, CD3–CD56 + cells, and immunoglobulin M in patients with uterine cervical neoplasms. Moreover, the combination treatment resulted in a reduction of adverse reactions, including gastrointestinal reactions (RR = 0.52, 95% CI: 0.42–0.64, P < .00001), radiation proctitis (RR = 0.47, 95% CI: 0.33–0.68, P < .0001), myelosuppression (RR = 0.41, 95% CI: 0.26–0.64, P < .0001), as well as carcinoembryonic antigen (CEA) and squamous cell carcinoma antigen (SCC-Ag) levels. Additionally, the treatment exhibited an inhibitory effect on white blood cells (WBCs) and platelets (PLTs). Conclusion: The amalgamation of Xihuang Pills/Capsules with conventional anti-tumor therapy proves to be both effective and safe in the treatment of cervical neoplasms. However, further validation through high-quality RCTs is necessary to substantiate these findings.

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“…However, the effect of NACT+CCRT on survival is unknown, necessitating further study. An earlier retrospective analysis of ours demonstrated that paclitaxel plus platinum (TP)-based NACT+CCRT could improve survival in patients with LACC, particularly those with tumor diameter >4 cm [ 13 ]. In the present study, we conducted a prospective randomized trial to compare the efficacy and safety of TP-based NACT+CCRT vs. CCRT in LACC patients with large tumor masses.…”

Section: Introductionmentioning

confidence: 99%

Improving the efficacy and safety of concurrent chemoradiotherapy by neoadjuvant chemotherapy: a randomized controlled study of locally advanced cervical cancer with a large tumor

Li,

Mei,

Yin

et al. 2024

J Gynecol Oncol

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Objective To compare the efficacy and safety of neoadjuvant chemotherapy combined with concurrent chemoradiotherapy (NACT+CCRT) vs. concurrent chemoradiotherapy (CCRT) in locally advanced cervical cancer (LACC) patients with large tumor masses. Methods LACC patients with localized tumor diameter >4 cm, were randomly allocated in an unblinded 1:1 ratio to NACT+CCRT or CCRT groups. Patients in the NACT+CCRT group were given paclitaxel combined with cisplatin (TP) NACT every 3 weeks for 2 cycles, followed by CCRT, with the chemotherapy regimen the same as for NACT. CCRT group were given CCRT with the same as for NACT. Results From March 1, 2019, to June 30, 2021, 146 patients were included in the final analysis. Sixty-eight (93.2%) patients in the NACT+CCRT group and 66 (90.4%) patients in the CCRT group completed the expected treatment course. The complete response (CR) rate in the NACT+CCRT group was significantly higher than in the CCRT group (87.7% vs. 67.6%, χ 2 =54.540, p=0.000). In the NACT+CCRT group, the 1- and 2-year overall survival (OS) rates were significantly higher than those in the CCRT group (96% vs. 89% and 89% vs. 79%, χ 2 =5.737, p=0.017). Additionally, the rate of recurrences and distant metastases was significantly lower in the NACT+CCRT group than in the CCRT group (4.11% vs. 7.35%, χ 2 =4.059, p=0.021). Most treatment-related adverse events in both groups were grade 3. Conclusion Compared to CCRT, NACT+CCRT might improve the treatment completion rate, increase CR rate and 1- and 2-year OS rates, and reduce distant metastases rate for LACC patients with large tumor masses.

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A Comparison of Different Schemes of Neoadjuvant Chemotherapy Followed by Concurrent Chemotherapy and Radiotherapy for Locally Advanced Cervical Cancer: A Retrospective Study

Cited by 11 publications

References 34 publications

Diagnostic value of dynamic enhanced multi-slice spiral CT in lymph node metastasis of cervical cancer and analysis of the causes of missed diagnosis

Diagnostic value of dynamic enhanced multi-slice spiral CT in lymph node metastasis of cervical cancer and analysis of the causes of missed diagnosis

Meta-analysis of the efficacy and safety of Xihuang Pills/capsules in adjuvant treatment of uterine cervical neoplasms

Improving the efficacy and safety of concurrent chemoradiotherapy by neoadjuvant chemotherapy: a randomized controlled study of locally advanced cervical cancer with a large tumor

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