A comparison of dioctahedral smectite and iodine glycerin cream with topical mouth rinse in treatment of chemotherapy induced oral mucositis: A pilot study

Lin, Jieqiong; Fan, Zu-Yan; Q, Lin; Wu, Dong-hao; Wu, Xiang-yuan; Chen, Yanru; Fang, Heng-Ying; Wu, Dong-Bing; Wen, Ji; Dong, Min; Ma, Xiaokun; Wan, Xiang-Bo

doi:10.1016/j.ejon.2014.10.006

Cited by 12 publications

(19 citation statements)

References 33 publications

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“…In general, 18 studies chose the OM degree to estimate the final treatment outcomes [2,10,11,12,13,14,15,17,18,19,20,21,22,23,24,25,27,28]. 2 studies chose the manifestation of progression or remission of this disease [13,22], 7 studies—the duration of the disease [3,15,19,20,21,24,26] and 3 attempted to determine the time of occurrence of OM after the oncologic treatment had started [23,26,27]. One study evaluated the results according to questionnaires in which patients described their oral mucosa condition subjectively [16].…”

Section: Resultsmentioning

confidence: 99%

“…Lin et al [21] compared the efficiency of dioctahedral smectite and iodine glycerin (DSIG) cream for prevention and treatment of chemotherapy induced OM. The study sample consisted of 130 subjects that were divided into 2 groups: one group was treated with DSIG cream (n = 63) and the other received placebo mouthwash treatment (n = 67).…”

Section: Resultsmentioning

confidence: 99%

“…In the antimicrobial product subgroup, significant therapeutic and preventive effects were obtained with the use of chlorhexidine [19], Smecta [21], Actovegin [22] and Kangfuxin [23], but comparing the efficacy of these products would be difficult due to the varying assessment criteria and treatment protocols chosen by researchers.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 20 out to 21 studies indicated localization of an oncological disease: hematologic cancer [2], colon cancer [3], head and neck cancer [10,11], hematologic cancer [12,13,14], head and neck cancer [15,16,17,18,19,20], hematologic cancer [21], breast cancer [22], head and neck cancer [23,24,25,26,27], hematological cancer [28]. In all studies, the oncologic treatment method is described: chemotherapy [2], combined chemotherapy and radiotherapy [3,10,11], radiotherapy [11], chemotherapy [12,13,14], combined chemotherapy and radiotherapy [15,16], radiotherapy [17,18], combined chemotherapy and radiotherapy [18], chemotherapy [19], combined chemotherapy and radiotherapy [20], radiotherapy [20], chemotherapy [21], combined chemotherapy and radiotherapy [22,23], radiotherapy [24], combined chemotherapy and radiotherapy [25], radiotherapy [26], combined chemotherapy and radiotherapy [27], chemotherapy [28].…”

Section: Methodsmentioning

confidence: 99%

“…In all studies, the oncologic treatment method is described: chemotherapy [2], combined chemotherapy and radiotherapy [3,10,11], radiotherapy [11], chemotherapy [12,13,14], combined chemotherapy and radiotherapy [15,16], radiotherapy [17,18], combined chemotherapy and radiotherapy [18], chemotherapy [19], combined chemotherapy and radiotherapy [20], radiotherapy [20], chemotherapy [21], combined chemotherapy and radiotherapy [22,23], radiotherapy [24], combined chemotherapy and radiotherapy [25], radiotherapy [26], combined chemotherapy and radiotherapy [27], chemotherapy [28]. …”

Section: Methodsmentioning

confidence: 99%

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Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis

et al. 2019

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Background and objectives: Oral mucositis is one of the main adverse events of cancer treatment with chemotherapy or radiation therapy. It presents as erythema, atrophy or/and ulceration of oral mucosa. It occurs in almost all patients, who receive radiation therapy of the head and neck area and from 20% to 80% of patients who receive chemotherapy. There are few clinical trials in the literature proving any kind of treatment or prevention methods to be effective. Therefore, the aim of this study is to perform systematic review of literature and examine the most effective treatment and prevention methods for chemotherapy or/and radiotherapy induced oral mucositis. Materials and methods: Clinical human trials, published from 1 January 2007 to 31 December 2017 in English, were included in this systematic review of literature. Preferred reporting items for systematic reviews and meta-analysis (PRISMA) protocol was followed while planning, providing objectives, selecting studies and analyzing data for this systematic review. “MEDLINE” and “PubMed Central” databases were used to search eligible clinical trials. Clinical trials researching medication, oral hygiene, cryotherapy or laser therapy efficiency in treatment or/and prevention of oral mucositis were included in this systematic review. Results: Results of the studies used in this systematic review of literature showed that laser therapy, cryotherapy, professional oral hygiene, antimicrobial agents, Royal jelly, L. brevis lozenges, Zync supplementation and Benzydamine are the best treatment or/and prevention methods for oral mucositis. Conclusions: Palifermin, Chlorhexidine, Smecta, Actovegin, Kangfuxin, L. brevis lozenges, Royal jelly, Zync supplement, Benzydamine, cryotherapy, laser therapy and professional oral hygiene may be used in oral mucositis treatment and prevention.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis

et al. 2019

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Management of Mucositis During Chemotherapy: From Pathophysiology to Pragmatic Therapeutics

et al. 2015

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Chemotherapy-induced mucositis is a common condition caused by the breakdown of the mucosal barrier. Symptoms can include pain, vomiting and diarrhoea, which can often necessitate chemotherapy treatment breaks or dose reductions, thus compromising survival outcomes. Despite the significant impact of mucositis, there are currently limited clinically effective pharmacological therapies for the pathology. New emerging areas of research have been proposed to play key roles in the development of mucositis, providing rationale for potential new therapeutics for the prevention, treatment or management of chemotherapy-induced mucositis. This review aims to address these new areas of research and to comment on the therapeutics arising from them.

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Integrative Onkologie – was sind die Fakten?

Münstedt¹

2018

TumorDiagn u Ther

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A comparison of dioctahedral smectite and iodine glycerin cream with topical mouth rinse in treatment of chemotherapy induced oral mucositis: A pilot study

Cited by 12 publications

References 33 publications

Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis

Prevention and Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis

Management of Mucositis During Chemotherapy: From Pathophysiology to Pragmatic Therapeutics

Integrative Onkologie – was sind die Fakten?

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