A Comparison of Focused and Unfocused Ultrasound for Microbubble-Mediated Gene Delivery

Anderson, Cynthia D.; Walton, Chad B.; Shohet, Ralph V.

doi:10.1016/j.ultrasmedbio.2021.02.016

Cited by 14 publications

(14 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An order of magnitude higher levels of expression was reported, and small areas of intense luciferase expression were observed in the left ventricle, confirming delivery. 109 A strategy called multifunctional pathology-mapping theranostic nanoplatform (MPmTN) was proposed for treatment of plaques in atherosclerotic thrombosis. The poly(lactic-coglycolic acid) (PLGA) nanoparticles (NPs) encapsulated in MPmTN change phase from nanodroplets to gas MBs and promoted bioeffects and therapeutic US exposure.…”

Section: Interaction Of Ultrasound Withmentioning

confidence: 99%

Ultrasound-Enabled Therapeutic Delivery and Regenerative Medicine: Physical and Biological Perspectives

Bansal

Jha

Bhatia

et al. 2021

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

The role of ultrasound in medicine and biological sciences is expanding rapidly beyond its use in conventional diagnostic imaging. Numerous studies have reported the effects of ultrasound on cellular and tissue physiology. Advances in instrumentation and electronics have enabled successful in vivo applications of therapeutic ultrasound. Despite path breaking advances in understanding the biophysical and biological mechanisms at both microscopic and macroscopic scales, there remain substantial gaps. With the progression of research in this area, it is important to take stock of the current understanding of the field and to highlight important areas for future work. We present herein key developments in the biological applications of ultrasound especially in the context of nanoparticle delivery, drug delivery, and regenerative medicine. We conclude with a brief perspective on the current promise, limitations, and future directions for interfacing ultrasound technology with biological systems, which could provide guidance for future investigations in this interdisciplinary area.

show abstract

Section: Interaction Of Ultrasound Withmentioning

confidence: 99%

Ultrasound-Enabled Therapeutic Delivery and Regenerative Medicine: Physical and Biological Perspectives

Bansal

Jha

Bhatia

et al. 2021

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…In vitro studies showed that US-induced acoustic cavitation of MBs can transiently increase the cell membrane permeability and enhance cellular uptake of the plasmid. 28 , 29 , 30 UMGD has been applied in vivo to deliver pharmocologics or genetic material into different target organs such as liver, 31 , 32 , 33 brain, 34 , 35 pancreas, 36 kidney, 37 cornea, 38 and others 39 for therapeutic treatment. Previously, we showed that therapeutic UMGD enhanced FIX gene transfer by the intrahepatic delivery of an albumin-based US contrast agent, Optison, combined with a FIX plasmid into the mouse liver, which was simultaneously treated with an US.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-mediated gene delivery of factor VIII plasmids for hemophilia A gene therapy in mice

Song¹,

Lyle²,

Noble-Vranish³

et al. 2022

Molecular Therapy - Nucleic Acids

View full text Add to dashboard Cite

“…Therefore, it is essential to develop safe and effective treatments with fewer side effects. One of these treatment methods is ultrasound (US)-targeted microbubble destruction (UTMD) ( Anderson et al, 2021 ; Zhao et al, 2021 ). Recently, low-frequency US combined with microbubbles (MBs) has shown potential for tumor therapy.…”

Section: Introductionmentioning

confidence: 99%

“…The use of UTMD-mediated drug delivery is a new method that has been applied in many studies, including the treatment of various central nervous system diseases. Selective blood–tumor barrier opening is an effective method to improve the chemotherapeutic efficacy for brain glioma ( Anderson et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…A large number of studies have indicated that gambogic acid (GA) has good clinical therapeutic effect in a variety of tumors including lung cancer, liver cancer, breast cancer, cervical cancer, nasopharyngeal carcinoma, and gastric cancer ( Anderson et al, 2021 ; Li et al, 2021 ). Emerging data suggest that GA exhibits the antitumor effect through multiple distinct mechanisms including the inhibition of cell proliferation, influencing telomerase activity and angiogenesis, induction of apoptosis, and cell cycle arrest ( Zhang et al, 2020 ; Chen et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Gambogic Acid–Loaded Porous-Lipid/PLGA Microbubbles in Combination With Ultrasound-Triggered Microbubble Destruction on Human Glioma

Wang

Dong

Wei

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Gambogic acid (GA) is a highly effective antitumor agent, and it is used for the treatment of a wide range of cancers. It is challenging to deliver drugs to the central nervous system due to the inability of GA to cross the blood–brain barrier (BBB). Studies have shown that ultrasound-targeted microbubble destruction can be used for transient and reversible BBB disruption, significantly facilitating intracerebral drug delivery. We first prepared GA–loaded porous-lipid microbubbles (GA porous-lipid/PLGA MBs), and an in vitro BBB model was established. The cell viability was detected by CCK-8 assay and flow cytometry. The results indicate that U251 human glioma cells were killed by focused ultrasound (FUS) combined with GA/PLGA microbubbles. FUS combined with GA/PLGA microbubbles was capable of locally and transiently enhancing the permeability of BBB under certain conditions. This conformational change allows the release of GA to extracellular space. This study provides novel targets for the treatment of glioma.

show abstract

A Comparison of Focused and Unfocused Ultrasound for Microbubble-Mediated Gene Delivery

Cited by 14 publications

References 49 publications

Ultrasound-Enabled Therapeutic Delivery and Regenerative Medicine: Physical and Biological Perspectives

Ultrasound-Enabled Therapeutic Delivery and Regenerative Medicine: Physical and Biological Perspectives

Ultrasound-mediated gene delivery of factor VIII plasmids for hemophilia A gene therapy in mice

Effect of Gambogic Acid–Loaded Porous-Lipid/PLGA Microbubbles in Combination With Ultrasound-Triggered Microbubble Destruction on Human Glioma

Contact Info

Product

Resources

About