A comparison of Ki-67 antigen presentation in acute generalized exanthematous pustulosis and pustular psoriasis

Chang, Shyue‐Luen; Hu, Sindy; Hung, Shuen‐Iu; Huang, Yau‐Li; Hsiao, Wen-Chin; Chung, Wen‐Hung

doi:10.1007/s00403-010-1046-3

Cited by 22 publications

(20 citation statements)

References 23 publications

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“…Prior to this, AGEP was termed a pustular drug eruption or was considered a variant of pustular psoriasis. Both pustular psoriasis and AGEP are caused by T‐cell mediated generation of neutrophils with hyperproliferation of keratinocytes . Both present with fever and leukocytosis, however, AGEP is typically more abrupt in onset with a high‐grade fever and marked leukocytosis.…”

Section: Introductionmentioning

confidence: 99%

Acute generalized exanthematous pustulosis: atypical presentations and outcomes

Kostopoulos

Krishna

Brinster

et al. 2014

Acad Dermatol Venereol

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Acute generalized exanthematous pustulosis (AGEP) is an acute drug eruption characterized by erythematous plaques and papules studded with numerous, pinpoint pustules. Several atypical clinical presentations and triggers of AGEP have been described in the literature. These include systemic presentations similar to toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS) and localized presentations mimicking other medication reactions. We herein aim to review atypical presentations and medication triggers of AGEP to assist clinicians in recognizing this condition and making appropriate therapeutic interventions.

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Section: Introductionmentioning

confidence: 99%

Acute generalized exanthematous pustulosis: atypical presentations and outcomes

Kostopoulos

Krishna

Brinster

et al. 2014

Acad Dermatol Venereol

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“…3 A vast array of growth factors, cytokines, inflammatory mediators, and other biological markers are upregulated in psoriatic lesions; some of these alterations also persist in nonlesional skin. 5 Labeling by Ki-67 is a useful way to determine the proliferative activity of any tissue, including psoriasis. 5 Labeling by Ki-67 is a useful way to determine the proliferative activity of any tissue, including psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Expression of GLUT-1 and Ki-67 in Chronic Plaque Psoriasis

Abdou¹,

Maraee

Eltahmoudy³

et al. 2013

The American Journal of Dermatopathology

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Many inflammatory mediators and other biological markers are upregulated in psoriatic lesions; some of these alterations also persist in nonlesional skin. Glucose is the major source of energy for cells, and glucose transporter 1 is the most common glucose transporter in humans (GLUT-1). The present study aimed at evaluating the pattern of expression of GLUT-1 and Ki-67 in psoriatic skin (involved and uninvolved) and correlating their expression with the clinicopathological parameters in the studied patients. This study was carried out on 30 patients presented with chronic plaque psoriasis and 10 apparently healthy volunteers as a control group. GLUT-1 was not expressed in epidermis of normal skin, whereas it was expressed in 76.6% of uninvolved and 86.7% of involved skin of psoriatic patients, where both the latter differed significantly regarding the intensity (P = 0.001) and localization (P = 0.001) of GLUT-1 expression. The percentage of Ki-67 expression did not differ significantly between involved and uninvolved skin of psoriatic patients, but they were higher than that of normal skin of control group. Nucleolar pattern of Ki-67 expression was significantly associated with male sex (P = 0.05), marked parakeratosis (P = 0.01), and marked angiogenesis (P = 0.05). GLUT-1 expression was associated with degree of acanthosis and percentage of Ki-67 expression. From this study, GLUT-1 is upregulated in psoriatic epidermis and may be involved in facilitation of keratinocyte proliferation in psoriasis. Nucleolar pattern of Ki-67 is an indicator of progressive keratinocyte proliferation in psoriasis.

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“…Its determination is also used in non-neoplastic lesions which are characterized by uncontrollable proliferation of cells, for example in psoriasis [10]. In this disease, excessive proliferation of cells and an improper keratinization process, together with immune disorders, belong to basic pathogenetic mechanisms [11,12].…”

Section: Introductionmentioning

confidence: 99%

Influence of phototherapy in psoriasis on ki-67 antigen expression: a preliminary study

Jesionek-Kupnicka

Chomiczewska-Skóra²,

Rotsztejn³

2013

pjp

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Antigen Ki-67 is a non-histone nuclear protein, closely connected with cell proliferation. Determining Ki-67 allows for a quick and reliable evaluation of the growth fraction of the studied cell population. It serves as a marker of proliferative activity in neoplasms and other diseases with excessive cell proliferation such as psoriasis. Evaluation of Ki-67 expression in epidermal cells was performed in 10 individuals suffering from plaque psoriasis, before and after one of three methods of phototherapy: broadband UVB, narrowband UVB or PUVA. We observed increased Ki-67 antigen expression in psoriatic lesions. The percentage of Ki-67 positive nuclei in the epidermis affected by the disease ranged from 0 to 30% and in the macroscopically healthy surrounding tissue the percentage was from 0 to 10%. After phototherapy the expression in lesional skin decreased (p < 0.01). The greatest decrease was observed after the application of PUVA therapy (from 25 to 10% of cells, p < 0.05). No significant differences were observed in the perilesional skin with regard to Ki-67 antigen expression before or after phototherapy. On the basis of our own study and studies conducted by other researchers, it can be concluded that reduced Ki-67 expression after the application of PUVA and UVB therapies in the psoriatic epidermis is not a characteristic result of phototherapy only. It is a characteristic property of any effective psoriasis therapy.

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A comparison of Ki-67 antigen presentation in acute generalized exanthematous pustulosis and pustular psoriasis

Cited by 22 publications

References 23 publications

Acute generalized exanthematous pustulosis: atypical presentations and outcomes

Acute generalized exanthematous pustulosis: atypical presentations and outcomes

Immunohistochemical Expression of GLUT-1 and Ki-67 in Chronic Plaque Psoriasis

Influence of phototherapy in psoriasis on ki-67 antigen expression: a preliminary study

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