A Comparison of Macular Structure Imaged by Optical Coherence Tomography in Preterm and Full-Term Children

Ecsedy, Mónika; Szamosi, Anna; Karkó, Cecilia; Zubovics, Laszlo; Varsányi, Balázs; Németh, János; Récsán, Zsuzsa

doi:10.1167/iovs.06-1199

Cited by 95 publications

(91 citation statements)

References 18 publications

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“…5 OCT has revealed changes not evident on ophthalmoscopy, but these can be compatible with good visual acuity. 6,7,[9][10][11] Authors have questioned the possibility of a non-retinal aetiology for visual deficits, so examination of the choroid is warranted. 1 The choroid serves functions including metabolic support for the RPE and retina, acting as a heat sink, and absorbing excess light.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown shallowing of the foveal depression, thickening of the central macula, and a continuity of inner retinal layers across the fovea in those born severely preterm, often despite normal macular appearance on ophthalmoscopy. [6][7][8][9][10][11][12][13][14] However, these macular changes evident on OCT are still compatible with good visual acuity. 6,7,[9][10][11] This has prompted authors to suggest that other factors might be contributory to the variation in vision seen in these patients.…”

Section: Introductionmentioning

confidence: 97%

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Choroidal thickness in regressed retinopathy of prematurity

Anderson

Ramasamy

Lythgoe

et al. 2014

Eye

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Purpose To compare choroidal thickness in patients with regressed retinopathy of prematurity (ROP) with healthy controls using enhanced depth imaging optical coherence tomography (EDI OCT) Methods Twenty-four children and young adults (41 eyes) with regressed ROPZstage 3 had undergone EDI OCT with Spectralis FD-OCT as part of their clinical record. Their refraction, best-corrected visual acuity, and ophthalmoscopic findings were recorded. Corresponding data was collected prospectively from 33 healthy controls (58 eyes) who had been born at term. Choroidal thickness was measured independently by two observers subfoveally and at 1500 mm nasal and temporal to the fovea using EDI OCT. Results Mean subfoveal choroidal thickness, adjusted for refraction, was 271.1 mm (95% CI, 247.8-294.5) in the ex-ROP group, which was significantly thinner than 327.4 mm (95% CI, 293.8-360.9) in controls (P ¼ 0.008). Similarly, mean adjusted temporal choroidal thickness was 257.2 mm (95% CI, 240.2-274.2) in ex-ROP's vs 320.5 mm (95% CI, 288.6-352.3) in controls (P ¼ 0.001). There was no statistically significant difference in the nasal measurement. In the ex-ROP group, there was no significant correlation between subfoveal choroidal thickness and gestational age (r s ¼ 0.16, P ¼ 0.46) or birthweight (r s ¼ 0.03, P ¼ 0.90). In eyes without copathology in addition to regressed ROP (29 eyes, 19 patients), there was no significant correlation between subfoveal choroidal thickness and visual acuity. Conclusions Our findings of thinner subfoveal and temporal macular choroidal thickness in regressed ROP support the case for choroidal involvement in the pathogenesis of this condition.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Choroidal thickness in regressed retinopathy of prematurity

Anderson

Ramasamy

Lythgoe

et al. 2014

Eye

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“…Esta pesquisa reforça a ideia de que as alterações encontradas ao exame de OCT são uma manifestação da organização estrutural da retina do prematuro e parece não sofrer influência da gravidade da ROP ou do processo de tratamento exigido pela ROP em seu estágio mais severo (6)(7)(8) . Existe uma diferença estatisticamente significativa entre a espessura foveal do grupo G1 e do grupo G2, observada neste estudo.…”

Section: Discussionunclassified

“…Estas medidas podem servir de base comparativa para o presente estudo (3)(4)(5) . Entre as crianças nascidas prematuramente observam-se, ao exa me de OCT, alterações típicas na região macular e foveal quando comparadas às crianças nascidas a termo (6)(7)(8) . A ciência ainda não tem uma resposta precisa para explicar o que realmente acontece com a maturação destas camadas retinianas, entre nascidos prematuros (6) .…”

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“…Entre as crianças nascidas prematuramente observam-se, ao exa me de OCT, alterações típicas na região macular e foveal quando comparadas às crianças nascidas a termo (6)(7)(8) . A ciência ainda não tem uma resposta precisa para explicar o que realmente acontece com a maturação destas camadas retinianas, entre nascidos prematuros (6) . Em 2010, nos EUA, pesquisadores compararam a avaliação das imagens por OCT de pacientes adultos nascidos prematuros, e adultos nascidos a termo.…”

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Características estruturais maculares de olhos de pré-escolares nascidos prematuros: análise por tomografia de coerência óptica e oftalmoscopia binocular indireta

Bonotto¹,

Moreira

Bortolotto

2013

Arq. Bras. Oftalmol.

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IntroduçãoO estudo da interferometria óptica iniciou-se em 1969 e deu origem aos equipamentos atuais de tomografia de coerência óptica (OCT) (1) . A partir dos anos 90 com contínua progressão, houve grande impulso no conhecimento e na aplicabilidade médica deste método que utiliza uma imagem refletida da luz do laser após atravessar as camadas do tecido, in vivo (2) . Atualmente os aparelhos de tomografia de coerência óptica (OCT) apresentam dados comparativos de normalidade padronizados para comparação entre adultos acima de 18 anos. Abaixo desta Características estruturais maculares de olhos de pré-escolares nascidos prematuros: análise por tomografia de coerência óptica e oftalmoscopia binocular indireta

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Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity

et al. 2022

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IMPORTANCEPreterm infants are at risk for poor visual acuity (VA) outcomes, even without retinal problems on ophthalmoscopy. Infant retinal microanatomy may provide insight as to potential causes.OBJECTIVE To evaluate the association between preterm infant retinal microanatomy and VA at 9 months' corrected age. DESIGN, SETTING, AND PARTICIPANTSThis prospective observational study took place from November 2016 and December 2019 at a single academic medical center and included preterm infants enrolled in Study of Eye Imaging in Preterm Infants (BabySTEPS). Infants were eligible for enrollment in BabySTEPS if they met criteria for retinopathy of prematurity (ROP) screening, were 35 weeks' postmenstrual age or older at the time of first OCT imaging, and a parent or guardian provided written informed consent. Of 118 infants enrolled in BabySTEPS, 61 were included in this analysis. Data were analyzed from March to April 2021. EXPOSURES Bedside optical coherence tomography (OCT) imaging at a mean (SD) 39.85 (0.79) weeks' postmenstrual age and monocular grating VA measurement at 9 months' corrected age. MAIN OUTCOMES AND MEASURESPresence and severity of macular edema and presence of ellipsoid zone at the fovea measured by extracting semiautomated thicknesses of inner nuclear layer, inner retina, and total retina at the foveal center; choroid across foveal 1 mm; and retinal nerve fiber layer (RNFL) across the papillomacular bundle (PMB). Pearson correlation coefficients were calculated and 95% CIs were bootstrapped for the association between retinal layer thicknesses and continuous logMAR VA. Associations were analyzed between retinal microanatomy and normal (3.70 cycles/degree or greater) vs subnormal grating VA at 9 months' corrected age using logistic regression and with logMAR VA using linear regression, adjusting for birth weight, gestational age, and ROP severity at the time of OCT imaging and accounting for intereye correlation using generalized estimating equations. RESULTSThe mean (SD; range) gestational age of included infants was 27.6 (2.8; 23.0-34.6) weeks, and mean (SD; range) birth weight was 958.2 (293.7; 480-1580) g. In 122 eyes of 61 infants, the correlations between retinal layer thicknesses and logMAR VA were as follows: r, 0.01 (95% CI, −0.07 to −0.27) for inner nuclear layer; r, 0.19 (95% CI, 0.01 to 0.35) for inner retina; r, 0.15 (95% CI, −0.02 to 0.31) for total retina; r, −0.22 (95% CI, −0.38 to −0.03) for choroid; and r, −0.27 (95% CI, −0.45 to 0.10) for RNFL across the PMB. In multivariable analysis, thinner RNFL across the PMB (regression coefficient, −0.05 per 10-μm increase in RNFL thickness; 95% CI, −0.10 to −0.01; P = .046) and prior ROP treatment (regression coefficient, 0.33 for ROP treatment; 95% CI, 0.11 to 0.56; P = .003) were independently associated with poorer 9-month logMAR VA. CONCLUSIONS AND RELEVANCEIn preterm infants, RNFL thinning across the PMB was associated with poorer 9-month VA, independent of birth weight, gestational age, need for ROP treatment, and macular microanatom...

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A Comparison of Macular Structure Imaged by Optical Coherence Tomography in Preterm and Full-Term Children

Abstract: The central retinal thickness was significantly higher in the preterm groups than in the full-term group. This subtle macular modification may be related mainly to ROP. Prematurity had only a marginally significant role.

Cited by 95 publications

References 18 publications

Choroidal thickness in regressed retinopathy of prematurity

Choroidal thickness in regressed retinopathy of prematurity

Características estruturais maculares de olhos de pré-escolares nascidos prematuros: análise por tomografia de coerência óptica e oftalmoscopia binocular indireta

Association Between Retinal Microanatomy in Preterm Infants and 9-Month Visual Acuity

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