A comparison of multiple doses of fluticasone propionate and beclomethasone dipropionate in subjects with persistent asthma

Raphael, Gordon D.; Lanier, Robert Q.; Baker, James; Edwards, Lisa; Rickard, Kathy; Lincourt, W.

doi:10.1016/s0091-6749(99)70422-7

Cited by 29 publications

(27 citation statements)

References 36 publications

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“…The remaining two studies each contained four arms. 190,191 However, in one of these, 191 only two of the arms are relevant to this particular section as they evaluated low doses of BDP and FP [the other two arms evaluated high-doses and are reported in the section 'FP and BUD (review Q2 -high-dose ICS)', p. 67]. The remaining study 190 can be divided into two separate two-arm comparisons of BDP against FP, each with a dose ratio approximating 1:2 ( Table 13).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The total daily doses of FP:BDP that were compared were 200:400 µg (two studies 187,190 ), 250:400 µg (one study 188 ), 400:800 µg (three studies 183,190,191 ), 500:800 µg (one study 190 ) and 750-1500 µg (one study 191 ). A study by Szefler and colleagues 189 did not compare a single daily dose of each drug but instead compared sequentially increasing doses of FP with sequentially increasing doses of BDP, at a 1:2 dose ratio, over an 18-week period (100:200 µg in weeks 1-6, 400:800 µg in weeks 6-12 and 800:1600 µg in weeks 12-18).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…This was an MDI (Raphael and colleagues, FP -Flovent Inhalation aerosol, BDP -Flovent Inhalation Aerosol and Beclovent Inhalation Aerosol, all GSK; 190 Szefler and colleagues, FP -Flovent CFC, GSK, and BDP -Vanceril CFD, Schering-Plough; 189 Ige and colleagues, FP -Fluvent, BDP -Becotide, both GSK, 188 no further details of devices were given by Parakh and colleagues 183 183 Prasad and colleagues, 187 Raphael and colleagues…”

Section: Study Characteristicsmentioning

confidence: 99%

“…188,191 The severity of asthma was not mentioned in the remaining studies, but in two of the studies it can be inferred from the reported baseline percentage of predicted FEV 1 as being moderate 189 or moderate to severe. 190 In four of the studies the primary aim was to compare the efficacy of FP against that of BDP 183,187,188,190 at a dose ratio of (or approximating) 1:2. One study was described by the authors as "a feasibility study rather than a comparative trial" (Szefler and colleagues,189 p. 411), with the objective of comparing the relative beneficial and systematic effects for two ICS in a dose-response relationship.…”

mentioning

confidence: 99%

“…None of the efficacy studies specified 188 and India, 187 and a need for simultaneous testing of FP and BDP at a range of doses commonly used to treat asthma. 190 The reported methodological quality was generally inadequate. Details of randomisation and allocation concealment procedures were not always reported.…”

mentioning

confidence: 99%

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Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in adults and children aged 12 years and over

Shepherd¹,

Rogers²,

Anderson³

et al. 2008

Health Technol Assess

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