A comparison of nine scales to detect depression in Parkinson disease

Williams, James R.; Hirsch, Elaina S.; Anderson, Karen E.; Bush, Amber L.; Goldstein, Susanne R.; Grill, Stephen; Lehmann, Susan W.; Little, John T.; Margolis, Russell L.; Palanci, Justin; Pontone, Gregory M.; Weiss, Howard D.; Rabins, Peter V.; Marsh, Laura

doi:10.1212/wnl.0b013e31824d587f

Cited by 124 publications

(117 citation statements)

References 38 publications

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“…Data from 21 studies were included in the qualitative synthesis (table 1). One of the largest studies 33 (n 5 229) examined 9 depression screening tools and determined the GDS-30 was the most accurate and convenient tool for use (sensitivity 72% and specificity 82%). The Patient Health Questionnaire (PHQ) is a commonly used tool, which has been validated among patients with PD within 3 separate studies (sensitivities ranging from 50% to 100%; specificities 80%-93%).…”

Section: Resultsmentioning

confidence: 99%

“…The Patient Health Questionnaire (PHQ) is a commonly used tool, which has been validated among patients with PD within 3 separate studies (sensitivities ranging from 50% to 100%; specificities 80%-93%). 28,[33][34][35] Another tool was the Hamilton Depression Rating Scale (HDRS), including 24-, 21-, 17-, and 6-item versions across 6 studies. 33,[36][37][38][39][40] This is a commonly used clinician rating tool with reported sensitivities of 75%-100% and specificities ranging from 71% to 99%.…”

Section: Resultsmentioning

confidence: 99%

“…An SROC curve demonstrated an AUC of 0.89 (95% CI 0.86-0.92). 31,33,34,42 The Fagan plot showed a posttest probability for confirming disease of 52% and the reported posttest probability of ruling out disease was 9% (figure e-1D).…”

Section: Beck Depression Inventory 58mentioning

confidence: 97%

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Detecting depression in Parkinson disease

et al. 2016

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Detecting depression in Parkinson disease

et al. 2016

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“…Thorough analysis of available psychometric instruments might contribute to the rational choice of scales to use, by narrowing the number of options. For example Williams and collaborators 92 have recently studied 9 depression assessment scales for use in PD patient populations. They concluded that the instruments analyzed show validity provided that specific cutoff values are used, with the exception of the item "depression" of Unified Parkinson's Disease Rating Scale 92 ; the authors suggest that the 30-item GDS could be the most balanced choice in PD.…”

Section: Discussionmentioning

confidence: 99%

“…For example Williams and collaborators 92 have recently studied 9 depression assessment scales for use in PD patient populations. They concluded that the instruments analyzed show validity provided that specific cutoff values are used, with the exception of the item "depression" of Unified Parkinson's Disease Rating Scale 92 ; the authors suggest that the 30-item GDS could be the most balanced choice in PD. 92 In summary, no definitive conclusions can be drawn from this meta-analysis, although the available data suggests that depressive symptoms and anxiety improve following DBS at short-term, despite the significant heterogeneity of published results.…”

Section: Discussionmentioning

confidence: 99%

Depression and Anxiety Following Deep Brain Stimulation in Parkinson’s Disease: Systematic Review and Meta-Analysis

et al. 2014

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RESUMOIntrodução: A estimulação cerebral profunda (ECP) é eficaz na doença de Parkinson (DP) avançada, melhorando sintomas motores, flutuações e a qualidade de vida. No entanto, têm sido reportados efeitos adversos psiquiátricos, mas de uma forma variável e não padronizada. O objectivo deste artigo é analisar e sumarizar a evidência publicada sobre sintomas depressivos e ansiedade em doentes com DP após ECP, através de revisão sistemática e meta-análise. Material e Métodos: A PubMed foi pesquisada até Maio 2012 para identificar os estudos que avaliaram sintomas depressivos e ansiedade em doentes com doença de Parkinson submetidos a estimulação cerebral profunda bilateral do núcleo subtalâmico (NST) ou globo pálido interno (GPi). Foram feitas meta-análises com modelo de efeitos aleatórios para grupos de pelo menos três estudos homogéneos em relação ao desenho e instrumentos utilizados. Resultados: Foram selecionadas 63 referências; 98,4% continham dados relativos a escalas de avaliação de depressão e 38,1% relativos a ansiedade. Dois estudos não discriminavam o alvo usado; nos restantes 61 foi feita avaliação de curto prazo em 37 (60,7%), de médio prazo em 36 (59,0%) e de longo prazo em 5 (8,2%). Foram encontrados dados sobre variação pré/pós operatória em 57 (93,4%) estudos e 16 (26,2%) continham dados comparando ECP-NST versus outros grupos: ECP-GPi (n = 4 estudos, 25,0%), elegíveis para cirurgia (n = 6, 37,5%), e tratamento médico (n = 7, 43,8%). Discussão: É aparente a melhoria de depressão e ansiedade após ECP, sobretudo a curto prazo, efeito que tende a esbater-se em avaliações posteriores. Em relação à depressão a ECP-NST mostrou-se superior ao tratamento médico, mas não em comparação com o grupo de controlo elegível para cirurgia. Verificou-se o resultado oposto para a ansiedade, uma vez que os resultados favorecem o tratamento médico sobre a ECP-NST, e esta sobre o grupo de elegíveis para cirurgia. Não é evidente a superioridade de um alvo sobre o outro, mas os dados favorecem ligeiramente o GPi para ambos os tipos de sintomas. Conclusões:O padrão e curso dos sintomas depressivos e ansiedade após ECP na DP não são claros, mas ambos parecem melhorar no curto prazo, especialmente a depressão após a ECP-NST. Os resultados são bastante heterogéneos. Devem ser promovidos esforços no sentido de haver padronização de procedimentos de avaliação nos vários centros. Palavras-chave: Doença de Parkinson; Estimulação Cerebral Profunda; Ansiedade; Depressão; Meta-Análise. ABSTRACT Introduction: Deep brain stimulation (DBS) is effective in advancedParkinson's disease (PD), improving motor symptoms, fluctuations and quality of life. However, adverse psychiatric outcomes have been reported, albeit variably and in an unstandardized fashion. We aimed to summarize the published evidence on the outcomes of anxiety and depressive symptoms in Parkinson's disease patients following DBS, through systematic review and meta-analysis. Material and Methods: PubMed was searched until May 2012 to identify studies assessing anxiety and...

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Lower cognitive function attenuates the convergence between self‐ratings and observer ratings of depressive symptoms in late‐life cognitive impairment

Kwak

Kim

et al. 2023

Brain and Behavior

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Objectives Assessment of depressive symptoms in older adults is challenging especially in the presence of risks in cognitive impairment. We aimed to examine whether the convergence between two measures of depressive symptoms (self‐report and observer ratings) is affected by varying levels of cognitive function in older adults. Methods Self‐reported scale of depression, informant‐based rating of affective symptoms, and global cognitive function were assessed in 2533 older adults with no impairment, mild cognitive impairment, and Alzheimer's disease. The strength of rank‐order correlation between the Geriatric Depression Scale (GDS) and behavioral ratings of the Neuropsychiatric Inventory (NPI) was examined as the metric of convergent validity. Results The results showed that the strength of convergence between the two measurements gradually decreased as a function of lowered cognitive function. Overall tendency showed that diagnoses of cognitive impairment and lower levels of cognitive function were associated with lower correspondence between the two depression measurements. The loss of convergent validity is especially evident in the behavioral symptom of apathy. Conclusions Utilizing self‐report scales of depression in older adults requires a cautious approach even with minimal or mild levels of cognitive impairment.

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A comparison of nine scales to detect depression in Parkinson disease

Cited by 124 publications

References 38 publications

Detecting depression in Parkinson disease

Detecting depression in Parkinson disease

Depression and Anxiety Following Deep Brain Stimulation in Parkinson’s Disease: Systematic Review and Meta-Analysis

Lower cognitive function attenuates the convergence between self‐ratings and observer ratings of depressive symptoms in late‐life cognitive impairment

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