A comparison of several methods of macular hole measurement using optical coherence tomography, and their value in predicting anatomical and visual outcomes

Wakely, Laura; Rahman, Rubina; Stephenson, John

doi:10.1136/bjophthalmol-2011-301287

Cited by 115 publications

(139 citation statements)

References 10 publications

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“…Base diameter, macular hole inner opening and minimum linear diameter has been found to be predictor of anatomical and functional success in macular hole surgery; base diameter holding the strongest association. 18,19 However, both macular hole closure and visual improvement showed no correlation with minimum linear diameter, base diameter and hole height in our study. This may be due to the fact that only stage 3 MH were included in our study and thus hole size larger than 400 µm did not show correlation with anatomical and functional success.…”

Section: Discussioncontrasting

confidence: 48%

The outcome of vitrectomy with internal limiting membrane peeling for chronic macular hole at Biratnagar eye hospital: A tertiary eye care center in Nepal

et al. 2016

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Background: A macular hole is a full-thickness defect of retinal tissue involving the anatomic fovea, thereby affecting central visual acuity. Pars plana vitrectomy and gas tamponade is a recognised modality of treatment for macular hole.Larger holes are more likely to remain open after repair and late reopening after an initially closed macular hole is seen in macular holes larger than 400 μm.Aims and Objective: To evaluate the anatomical and functional outcome of pars plana vitrectomy with internal limiting membrane peeling for chronic stage 3 macular hole.Materials and Methods: Records of 15 patients with stage 3 chronic macular holes operated from 1st January 2013 to 30th June 2013 and completed 1 year of follow up were retrospectively evaluated and included in the study. Preoperative best distance corrected visual acuity (BCVA), preoperative macular hole size, final BCVA and macular hole status at 1 year follow up were recorded. Macular hole closure and visual improvement was calculated. Correlation of macular hole closure and visual improvement with various macular hole parameter was estimated.Results: Eleven (73.3%) macular holes closed at 1 year follow-up. Mean BCVA improved from 1.2 ± 0.27 to 0.89 ± 0.36 logarithm of minimum angle of resolution at 1 year (p<0.001). Visual improvement was seen in only eight (53.3%) eyes. Both macular hole closure and visual improvement showed no correlation with minimum linear diameter, base diameter and hole height.Conclusion: Chronic stage 3 macular hole can be closed successfully in majority of patients with fairly good visual improvement. Macular hole parameters of stage 3 holes may not have any correlation with the anatomical and visual outcome.Asian Journal of Medical Sciences Vol.7(6) 2016 43-46

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Section: Discussioncontrasting

confidence: 48%

The outcome of vitrectomy with internal limiting membrane peeling for chronic macular hole at Biratnagar eye hospital: A tertiary eye care center in Nepal

et al. 2016

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“…7 Further evidence for an adverse effect on retinal adhesion is that all eight of the BEAVRS cases with a retinal tear went on to develop a retinal detachment, whereas natural history studies of spontaneous posterior vitreous detachment suggest that only 30-50% of tears progress to retinal detachment. [10][11][12] The 46.9% incidence of widening of the FTMH basal diameter in failed ocriplasmin cases could have implications for visual outcomes, as increased basal diameter has previously been found to predict worse post-operative vision; 13 however, this was not found in the MIVI TRUST trials where the acuity improvement in failed ocriplasmin eyes was the same as in placebo treated eyes. 14,15 There is uncertainty as to the cause of the observed widened basal diameter.…”

Section: Discussionmentioning

confidence: 54%

Real world outcomes of ocriplasmin use by members of the British and Eire Association of Vitreoretinal Surgeons

Haynes

Yorston

Laidlaw

et al. 2016

Eye

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Purpose To describe a survey of the use of ocriplasmin by members of the British and Eire Association of VitreoRetinal Surgeons (BEAVRS) for VitreoMacular Traction (VMT) and Full Thickness Macular Hole (FTMH) and compare it to published MIVI TRUST trial data. Methods All 173 BEAVRS members were contacted by email in October 2014 requesting data on all cases treated with ocriplasmin up to that date. The total number of cases, FTMH closure rate, VMT release rate and the frequency of adverse events were recorded. Results were compared with trial data. Results 48 members responded reporting results from 241 eyes. The respective BEAVRS and MIVI TRUST trial closure rates for small FTMHs were 42.1 and 58.3% (P = 0.09) and for medium FTMH 12.7 and 36.7% (P = 0.01). The respective VMT release rates were 34.1 and 37.4% (P = NS). Retinal detachment was observed in 3.3% of the BEAVRS cohort compared with 0.4% in MIVI TRUST. Reduction in visual acuity to o6/60 was observed in 5.8% of the BEAVRS cohort and 0.6% in MIVI TRUST. Other complications not reported in the MIVI TRUST trial included an increase in FTMH basal diameter following unsuccessful ocriplasmin use in 46.9% of BEAVRS cases and zonular instability at the time of subsequent phacoemulsification in 2.4%. Conclusion Macular hole closure rates were lower in the BEAVRS survey than published in the MIVI TRUST trial data. The incidence of adverse events was greater than previously reported. The reasons for these disparities are unknown but could include positive reporting bias inherent to retrospective surveys, treatment and population differences.

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“…Table 1 shows the representative OCT parameters repeatedly discussed in previous papers in terms of their potential as preoperative predictors for postoperative visual outcomes. The minimum diameter of MH, also known as the minimum linear dimension of MH, is identical to the above-mentioned MH size, one of the most studied OCT parameters so far [52,56,57,58,59,60,61,62,63,64]. Commonly, a smaller minimum diameter is associated with better postoperative visual acuity, irrespective of the presence/absence of a statistical significance.…”

Section: Preoperative Predictive Factorsmentioning

confidence: 91%

Predicting Visual Outcome following Surgery for Idiopathic Macular Holes

Kusuhara

Negi

2013

Ophthalmologica

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Since Kelly and Wendel [Arch Ophthalmol 1991;109:654-659] first reported successfully treating macular holes (MHs) using pars plana vitrectomy in 1991, MH surgery has been constantly improved. For example, introducing the removal of the internal limiting membrane considerably increased the closure rate of MHs, and the advent of microincision vitrectomy surgery reduced surgical trauma and decreased patient discomfort after surgery. As modern MH surgery can achieve a higher anatomical success rate and alleviate patients' postoperative distress, postoperative visual outcomes have lately become the primary concern. Informing patients of the expected visual acuity and visual improvement before surgery is ideal, but predicting postoperative visual outcomes is difficult because a large number of factors are associated with them. In this paper, we review previous studies and provide accumulating evidence for the relationship between individual prognostic factors and visual outcomes after MH surgery.

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A comparison of several methods of macular hole measurement using optical coherence tomography, and their value in predicting anatomical and visual outcomes

Cited by 115 publications

References 10 publications

The outcome of vitrectomy with internal limiting membrane peeling for chronic macular hole at Biratnagar eye hospital: A tertiary eye care center in Nepal

The outcome of vitrectomy with internal limiting membrane peeling for chronic macular hole at Biratnagar eye hospital: A tertiary eye care center in Nepal

Real world outcomes of ocriplasmin use by members of the British and Eire Association of Vitreoretinal Surgeons

Predicting Visual Outcome following Surgery for Idiopathic Macular Holes

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