A comparison of the effect of elemental and immune‐enhancing polymeric jejunal feeding on exocrine pancreatic function

Abstract

In this model of partial pancreatectomy, there was no significant difference in pancreatic exocrine output when use of an EF was compared with use of a PIEF for jejunal feeding. Further clinical studies are needed to determine the potential role of PIEF in pancreatic disease.

Nutrition, Inflammation, and Acute Pancreatitis

“…However, only two prospective studies showed that a polymeric formulation increases pancreatic enzyme secretion into the duodenum in comparison with an elemental formulation, and both of these studies were conducted in healthy volunteers [67, 107]. Conversely, a randomised controlled trial of patients undergoing resection of the pancreas showed that a polymeric formulation did not increase pancreatic secretion compared with an elemental formulation [108]. The latter finding supports the results of the systematic review by Petrov and colleagues that demonstrated no increase in adverse effects with the use of polymeric and fibre-enriched formulations.…”

Role of Enteral and Parenteral Nutrition

“…More than 100 different enteral nutrition formulations are available, classified into three categories: elemental or semi-elemental, polymeric and immunoenhanced (immunonutrition and probiotics). In acute pancreatitis, (semi)elemental nutrition is usually preferred over polymeric formulation because this formulation is supposed to have a superior absorption from the intestine, less stimulation of pancreatic secretions and a better tolerance (11). A meta-analysis compared the safety and the tolerance of different enteral nutrition formulations used in acute pancreatitis.…”