A Comparison of the Effect of Sevoflurane and Propofol on Ventricular Repolarisation after Preoperative Cefuroxime Infusion

Abstract

The aim of this study is to investigate the changes in QT, QTc, and Tp-e intervals and Tp-e/QT ratio on surface electrocardiogram (ECG) signals during anaesthesia induction using propofol or sevoflurane after preoperative cefuroxime infusion. Some 120 cases of gynaecological patients are randomly divided into propofol (P) and sevoflurane (S) groups (n=60). After cefuroxime (1.5 g) was infused in the two groups of patients, propofol target controlled infusion (TCI) was conducted in the P group for 5 min to realise a plasma concentration of 4 μg/ml while patients in the S group inhaled anaesthesia by infusing 1.3 MAC sevoflurane for 6 min. The 12-lead ECGs were separately collected before infusing cefuroxime (T1), after infusing cefuroxime (T2), and after infusing propofol or sevoflurane (T3) to measure QT and Tp-e intervals, calculate QTc and Tp-e/QT, and record MAP and HR. Finally, we demonstrated that QT, QTc, and Tp-e intervals and Tp-e/QT ratio had no change (P > 0.05) after cefuroxime infusion in the two groups of patients compared with that before infusing antibiotics. Moreover, after conducting preoperative cefuroxime infusion, using propofol and sevoflurane had no influence on Tp-e interval, but sevoflurane can significantly prolong QT and QTc intervals (P < 0.05).

Effects of dexmedetomidine on cardiac electrophysiology in patients undergoing general anesthesia during perioperative period: a randomized controlled trial

“…Our study still has certain limitations. Considering that sevoflurane might prolong QTc intervals [ 42 ], this study only included patients under totally intravenous general anesthesia. The effects of dexmedetomidine on cardiac electrophysiology under combined intravenous and inhalational general anesthesia needs further study.…”

Effects of Anesthetics on Cardiac Repolarization in Adults: A Network Meta-Analysis of Randomized Clinical Trials

“…The basic characteristics of the included studies are summarized in Table 1 (Ref. [2][3][4]7,8,[14][15][16][17][18][19][20][21]).…”

“…The quality of each RCT was assessed using the risk of bias and the modified Jadad score (Table 2, Ref. [2][3][4]7,8,[14][15][16][17][18][19][20][21]). Six RCTs [2,4,8,14,16,21] mentioned their randomization procedure using permuted block sizes of 6, a random samples table, or a computer-generated random code generator; the remaining RCTs did not mention how randomization was performed.…”

“…[2][3][4]7,8,[14][15][16][17][18][19][20][21]). Six RCTs [2,4,8,14,16,21] mentioned their randomization procedure using permuted block sizes of 6, a random samples table, or a computer-generated random code generator; the remaining RCTs did not mention how randomization was performed. Only two [14,16] reported allocation concealment via sealed envelopes.…”

“…Many studies have found that nearly all anesthetics increase the QTc interval [6]. Propofol appears to have the most minor effect on QTc prolongation [4,7,8]. Moreover, anesthetics can also potentially prolong QTD, QTcD, PWD, Tp-e interval, and Tp-e/QT ratio [2][3][4].…”