A Comparison of the Effects of Propofol and Midazolam on Memory During Two Levels of Sedation by Using Target-Controlled Infusion

Propofol infusion for sedation during spinal anesthesia

“…In the present study, about 30% of the patients had a memory of surgery. The memory effects of propofol and midazolam were reported to be similar [12]; however, while in a study using midazolam, no patients had had a memory of surgery [18]. Therefore, amnesic effects may be smaller with propofol than with midazolam.…”

“…The serum propofol concentration in patients sedated but responding to verbal stimulation was around 1.5 µg·ml −1 , using a target-controlled infusion system for dental surgery [11]. Using a target-controlled infusion, an OAAS score of 4 was obtained with a propofol concentration of 1.35 µg·ml −1 and an OAAS score of 1 was obtained with a propofol concentration of 1.62 µg·ml −1 [12]. Loss of verbal response occurred with a plasma propofol concentration of 1.6 µg·ml −1 and loss of consciousness occurred with a plasma propofol concentration of 1.9 µg·ml −1 [7].…”

Absence of explicit and implicit memory in unconscious patients using a TCI of propofol

“…Seven sedation studies investigated memory Implicit memory and propofol anaesthesia under propofol, five under propofol alone (16,20,(23)(24)(25) and two under propofol/alfentanil (26,27). They can be divided into propofol sedation studies and propofol anaesthesia studies.…”

“…The first test was the word-stem completion test (7,(20)(21)(22). The patients were given a list of 40 stems of three letters that were the stems of each target word of the two lists.…”

Pain management after lumbar spinal fusion surgery using continuous subcutaneous infusion of buprenorphine

“…Nausea was assessed using a 3-point score of 0 to 2 (0, none; 1, moderate; 2, severe). The Observer Assessment of Alertness/Sedation Scale (OAA/S) [13] was used to determine the level of sedation (Table 1). Assessments were made 2 and 4 h after starting the continuous subcutaneous infusion and at 8:00 a.m. and 6:00 p.m. on the first and second postoperative days.…”