A comparison of the modulation of antiblastics cytotoxicity by verapamil and dipyridamole in a human colon carcinoma cell line.

Berti, Emilio; Carrara, Maria; Ragazzi, Eugenio; D'Ancona, S; Berti, T

doi:10.3892/ijo.15.1.155

Cited by 3 publications

(5 citation statements)

References 5 publications

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“…Functioning of this protein is inhibited by Dpm, which blocks the uptake of adenosine . It is thought that dypiridamole may exert an indirect effect in cis -DDP accumulation by decreasing ATP-dependent drug efflux mechanisms associated to multidrug resistant transporters . In addition, Dpm may enhance cis -DDP accumulation by increasing cell membrane permeability.…”

Section: 1 Cisplatin Accumulationmentioning

confidence: 99%

“…In addition, Dpm may enhance cis -DDP accumulation by increasing cell membrane permeability. It has been reported that Dpm increases the cytotoxic activity of cisplatin in human colon carcinoma cells as well as in human ovarian cancer cells. , Moreover, a combination of 5-fluorouracil (5FU), cis -DDP, and Dpm has proven to be highly effective in patients with advanced gastric cancer. 5FU is a clinically used antineoplastic drug, which inhibits pyrimidine biosynthesis .…”

Section: 1 Cisplatin Accumulationmentioning

confidence: 99%

“…102 It is thought that dypiridamole may exert an indirect effect in cis-DDP accumulation by decreasing ATP-dependent drug efflux mechanisms associated to multidrug resistant transporters. 103 In addition, Dpm may enhance cis-DDP accumulation by increasing cell membrane permeability. It has been reported that Dpm increases the cytotoxic activity of cisplatin in human colon carcinoma cells as well as in human ovarian cancer cells.…”

Section: Cisplatin Accumulationmentioning

confidence: 99%

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Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance

2003

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Section: 1 Cisplatin Accumulationmentioning

confidence: 99%

Section: 1 Cisplatin Accumulationmentioning

confidence: 99%

Section: Cisplatin Accumulationmentioning

confidence: 99%

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Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance

2003

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“…Multidrug resistance (MDR) has been a significant problem in cancer chemotherapy, and overcoming the MDR phenomenon is a crucial aspect of cancer research. MDR and modulation of MDR has been intensively studied in vitro and in vivo 1–4 . The MDR phenotype is characterized by a low free intracellular cytotoxic drug concentration in comparison with its corresponding drug‐sensitive cells.…”

Section: Introductionmentioning

confidence: 99%

Modulation of multidrug resistance by andrographolid in a HCT‐8/5‐FU multidrug‐resistant colorectal cancer cell line

Han

et al. 2005

Chinese Journal of Digestive Diseases

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The HCT-8/5-FU multidrug-resistant colorectal cancer cell line has been successfully developed and because it has cross-resistance to 5-FU, ADM and DDP, it might serve as an ideal multidrug resistance (MDR) model for colorectal cancer research. The mechanism of HCT-8/5-FU resistance to chemotherapeutic agents might be related to the overexpression of P-170. Low concentrations of AG alone have no significant inhibition on HCT-8/5-FU and fail to induce apoptosis and to change cell cycles. AG might act as a chemosensitizer when co-administered with 5-FU, ADM and DDP, and the mechanism of reversal modulation of multidrug resistance by AG in the HCT-8/5-FU resistant cell line might be related to its downregulation of overexpression of P-170.

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“…This phenomenon is in most cases caused by the activity of the various transporters, multidrugresistance (MDR) gene-encoded P-glycoproteins, which pump anticancer drugs out of the cells. 64 Furthermore, there is mounting evidence that Pglycoprotein plays a significant role in the regulation of apoptosis induced by various stimuli whose overexpression provoked prolonged lifespans of monoclonal lymphocytes in B-cell lymphocytic leukaemia, providing them a resistance to programmed cell death. Verapamil is an effective MDR and P-glycoprotein modulator, able to inhibit their overexpression.…”

Section: Medical Therapymentioning

confidence: 99%

Towards an evidence-based understanding of Peyronie's disease

Cavallini

2005

Int J STD AIDS

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Medical therapy plays a pivotal role in the management of Peyronie's disease and should be performed prior to any surgery. Intraplaque collagenase, intraplaque verapamil, intraplaque interferon, oral acetyl-L-carnitine, oral propionyl-L-carnitine and oral colchicine have proved effective in Peyronie's disease. With the exception of collagenase, these drugs have displayed a number of activities whose final result is to improve immune response, to inhibit inflammation and to inhibit fibroblast metabolism and replication. Therefore, the primitive replicative (rather than reactive) nature of the disease is confirmed; this knowledge may be of help in the identification of new non-surgical therapies for Peyronie's disease.

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A comparison of the modulation of antiblastics cytotoxicity by verapamil and dipyridamole in a human colon carcinoma cell line.

Cited by 3 publications

References 5 publications

Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance

Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance

Modulation of multidrug resistance by andrographolid in a HCT‐8/5‐FU multidrug‐resistant colorectal cancer cell line

Towards an evidence-based understanding of Peyronie's disease

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