A Comparison of Three Doses of a Commercially Prepared Oral Midazolam Syrup in Children

Coté, Charles J.; Cohen, Ira Todd; Suresh, Santhanam; Rabb, Mary; Rose, John B.; Weldon, B. Craig; Davis, Peter J.; Bikhazi, George B.; Karl, Helen W.; Hummer, Kelly A.; Hannallah, Raafat S.; Khoo, Ko Chin; Collins, Patrice

doi:10.1097/00000539-200201000-00007

Cited by 77 publications

(83 citation statements)

References 31 publications

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“…The commercial preparations come in a variety of flavors that are highly accepted by children. Oral midazolam syrup is effective for producing sedation and anxiolysis within 10 to 20 min at such low doses as 0.25 mg/kg (Coté et al, 2002). Furthermore, midazolam has minimal effects on respiration and oxygen saturation even when administered at doses as large as 1.0 mg/kg (maximum, 20 mg) as the sole sedating medication to healthy children in a supervised clinical setting.…”

Section: Gabaergic Inhibition In Anesthesiologymentioning

confidence: 99%

“…Although there is a statistically significant relationship between the dose and time of onset for both sedation and anxiolysis, this difference is probably not clinically important. Satisfactory sedation and anxiolysis seem to last for up to 40 to 45 min (Coté et al, 2002). In comparative studies, parents of children undergoing bone marrow biopsy preferred midazolam to fentanyl for sedation (Sandler et al, 1992).…”

Section: Gabaergic Inhibition In Anesthesiologymentioning

confidence: 99%

See 1 more Smart Citation

Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology

et al. 2011

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Section: Gabaergic Inhibition In Anesthesiologymentioning

confidence: 99%

Section: Gabaergic Inhibition In Anesthesiologymentioning

confidence: 99%

Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology

et al. 2011

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“…before the procedure. 10 Patients were wheeled into the operation theatre, Standard Monitors like Pulse Oximeter, Blood pressure, ECG were connected and after recording Baseline parameters IV line accessed via 22G or 24G IV cannula, Ringer lactate maintenance fluid started, 11 the child was preoxygenated with 100% O2 for 3 minutes and induced with Inj. fentanyl 2 mic/kg IV and Inj.…”

Section: Study Methodsmentioning

confidence: 99%

A Comparative Study of 0.25% Bupivacaine and 0.25% Ropivacaine for Paediatric Caudal Block for Infraumbilical Surgeries

A¹,

N²,

Balasubramaniam³

2016

jemds

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BACKGROUNDRegional anaesthesia plays an enormous role in providing pain relief both in the intra-operative and post-operative periods in paediatrics. Caudal epidural anaesthesia is the most commonly performed regional anaesthetic technique in children. The availability of newer drugs with reduced toxic potentials led us to conduct a study in which we compared the duration of postoperative analgesia between the drugs for infraumbilical surgeries.To compare Bupivacaine and Ropivacaine in a concentration of 0.25%, given in a volume of 1 mL/kg through a single Presurgical Caudal block in children aged 2-8 years undergoing surgeries like herniotomy and circumcision in terms of duration of postoperative analgesia. MATERIALS AND METHODSThe present study was carried out in the Department of Anaesthesiology, Govt. Chengalpattu Medical College, Chengalpattu, in 60 patients of either sex of ASA Grade I, between the ages of 2 and 8 years. These patients were systematically randomised into groups of 30 each, Group A received 1 mL/kg of 0.25% Bupivacaine (0.5% solution diluted in equal volumes of normal saline) and Group B received 1 mL/kg of 0.25% Ropivacaine (0.5% solution diluted in equal volumes of Normal Saline) through the caudal route.Statistical Analysis -The data was analysed by statistical software SPSS 17.0 and XLSTAT 2013. Independent student 't' test was used to find the significance in continuous data between the two groups. Chi-square test was used to analyse categorical data. RESULTSThe two groups were comparable in their baseline characteristics like age, sex, weight, height, vital signs, duration and type of surgery. The duration of postoperative pain relief between the groups were 182.83±12.64 mins. in Group A and 110.17±8.66 in Group B with a P < 0.001. The time to full motor recovery was significantly less in Ropivacaine group than in bupivacaine group. In Group A 239.00±21.55 mins. and in Group B 162.00±20.24 mins. with a P < 0.001. CONCLUSIONCaudal Bupivacaine 0.25% in a dose of 1 mL/kg provided reliable and long lasting analgesia when compared to Ropivacaine 0.25% in children undergoing infraumbilical surgeries.

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“…The beneficial effects of midazolam include sedation, anxiolysis, and reduction of postoperative vomiting. A recent evidence-based clinical update has shown that oral midazolam (5) 0.5 mg/kg is effective in reducing both separation and induction anxiety in children, with minimal effect on recovery time. However, the acceptability of oral midazolam by pediatric patients is only 70%.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Intranasal Dexmedetomidine and Oral Midazolam for Premedication in Pediatric Anaesthesia - A Randomized Controlled Trial

J¹

2017

jmscr

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A Comparison of Three Doses of a Commercially Prepared Oral Midazolam Syrup in Children

Cited by 77 publications

References 31 publications

Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology

Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology

A Comparative Study of 0.25% Bupivacaine and 0.25% Ropivacaine for Paediatric Caudal Block for Infraumbilical Surgeries

Comparison of Intranasal Dexmedetomidine and Oral Midazolam for Premedication in Pediatric Anaesthesia - A Randomized Controlled Trial

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