A comparison of three sets of DSP algorithms for monitoring the production of ethanol in a fed-batch baker’s yeast fermenter

State Estimation and Trajectory Tracking Control for a Nonlinear and Multivariable Bioethanol Production System

“…In recent years, the bioprocess industry, so called white biotechnology (Heux et al, 2015), has gained an important position. This is because it has an important role in the production of high-added value products; such as recombinant proteins, vaccines and antibiotics in the pharmaceutical industry, or beer, wine, yeast in the manufacturing of agro-food goods, or biogas and compost in the treatment of urban and industrial solid organic wastes and wastewater (Mangesh and Jana, 2008), between others.…”

“…There are many operating modes for bioreactors: batch, fed-batch and continuous. Among the different modes, the fed-batch is preferred because of the operational flexibility that it provides (Mangesh and Jana, 2008). It consists of changing the feed rate of nutrients, inhibitors, catalysts or inducers along the process, whereas cells and products remain in the fermenter until the operation ends (Hecklau et al, 2016).…”

“…Also, it avoids formation of unwanted products and microorganism inhibition caused by overfeeding, and prevents the microorganism starvation induced by underfeeding (Ochoa, 2016). Ethanol production in a fed-batch fermenter is common in white biotechnology (Mangesh and Jana, 2008).…”