A Comparison of Two Differing Doses of Promethazine for the Treatment of Postoperative Nausea and Vomiting

Deitrick, Christine L.; Mick, Diane J.; Lauffer, Vickie; Prostka, Eloise; Nowak, Daniel; Ingersoll, Gail L.

doi:10.1016/j.jopan.2014.01.009

Cited by 15 publications

(9 citation statements)

References 12 publications

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“…Over half of studies involved interventions that were delivered during the preoperative phase of care (n=41, 48%); 13 studies delivered interventions during the intraoperative phase (n = 13, 15%); 24 , 26 , 31 , 43 , 46 , 51 , 74 , 75 , 86 , 92 , 97 , 99 , 101 13 studies (15%) delivered interventions solely in the postoperative phase, 36 , 39 , 44 , 47 , 48 , 60 , 66 , 68 , 73 , 77 , 82 , 90 , 107 Supplementary file 3 ; eight studies (9%) were based on interventions that were delivered during multiple phases of the perioperative pathway. 34 , 35 , 42 , 56 , 61 , 76 , 85 , 96 Almost half of the included studies assessed outcomes at multiple phases of the perioperative pathway (n = 34, 40%), whilst 24 studies (28%) assessed postoperative outcomes extending beyond the immediate PACU phase.…”

Section: Resultsmentioning

confidence: 99%

“…Six studies tested pericardium 6 (P6) acupressure; 29,43,64,69,73,89 two studies tested aromatherapy with or without additional therapies; 39,48 one study tested early hydration; 90 one study tested an individualised preoperative education intervention 40 and one study tested different doses of promethazine. 44…”

Section: Postoperative Nausea and Vomiting (Ponv) Prevention And Treamentioning

confidence: 99%

“…26,27,34,35,39,40,41,43,45,48,51,55,61,62,64,66,69,73,89,90,92,99,102,109 Five studies (6%) assessed outcomes only during the preoperative phase, 57,58,71,103,106 whilst only four studies assessed outcomes at a single phase of intraoperative care (n=4, 6%), 33,46,56,59,74 and seven studies assessed outcomes during PACU care only (n=7, 8%). 24,44,47,68,82,100,109 Issues Impacting Upon the Quality of Experimental Research Undertaken in the Perioperative Setting…”

Section: Phases Of Carementioning

confidence: 99%

See 2 more Smart Citations

<p>Nurse-Led Randomized Controlled Trials in the Perioperative Setting: A Scoping Review</p>

Munday¹,

Higgins²,

Mathew³

et al. 2020

JMDH

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Purpose: Nurses provide care at each phase of the complex, perioperative pathway and are well placed to identify areas of care requiring investigation in randomized controlled trials. Yet, currently, the scope of nurse-led randomized controlled trials conducted within the perioperative setting are unknown. This scoping review aims to identify areas of perioperative care in which nurse-led randomized controlled trials have been conducted, to identify issues impacting upon the quality of these trials and identify gaps for future investigation. Methods: This scoping review was conducted in reference to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews. Searches were conducted in PubMed, Embase, Cumulative Index for Nursing and Allied Health Literature and the Cochrane Central Register of Controlled Trials, with a date range of 2014-19. Sources of unpublished literature included Open Grey, and ProQuest Dissertation and Theses, Clinical Trials.gov and the Australian and New Zealand Clinical Trials Registry. After title and abstract checking, full-text retrieval and data extraction, studies were appraised using the Joanna Briggs Institute Critical Appraisal Checklists for randomized controlled trials. Data were synthesized according to the main objectives. Key information was tabulated. Results: From the 86 included studies, key areas where nurses have led randomized controlled trials include patient or caregiver anxiety; postoperative pain relief; surgical site infection prevention: patient and caregiver knowledge; perioperative hypothermia prevention; postoperative nausea and vomiting; in addition to other diverse outcomes. Issues impacting upon quality (including poorly reported randomization), and gaps for future investigation (including a focus on vulnerable populations), are evident. Conclusion: Nurse-led randomized controlled trials in the perioperative setting have focused on key areas of perioperative care. Yet, opportunities exist for nurses to lead experimental research in other perioperative priority areas and within different populations that have been neglected, such as in the population of older adults undergoing surgery.

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Section: Resultsmentioning

confidence: 99%

Section: Postoperative Nausea and Vomiting (Ponv) Prevention And Treamentioning

confidence: 99%

Section: Phases Of Carementioning

confidence: 99%

See 1 more Smart Citation

<p>Nurse-Led Randomized Controlled Trials in the Perioperative Setting: A Scoping Review</p>

Munday¹,

Higgins²,

Mathew³

et al. 2020

JMDH

View full text Add to dashboard Cite

show abstract

“…Promethazine is a phenothiazine derivative that competitively blocks histamine [H(1)] receptors and exhibits antiemetic and sedative properties. IV infusion of promethazine typically relieves PONV after 5 min and lasts for 2–6 h ( 7 , 15 ). However, in ambulatory surgical settings, promethazine has shown concerning sedative effects ( 7 , 8 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

The Effect of a Combination Treatment Using Palonosetron, Promethazine, and Dexamethasone on the Prophylaxis of Postoperative Nausea and Vomiting and QTc Interval Duration in Patients Undergoing Craniotomy under General Anesthesia: A Pilot Study

et al. 2016

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IntroductionPostoperative nausea and vomiting (PONV) is a displeasing experience that distresses surgical patients during the first 24 h after a surgical procedure. The incidence of postoperative nausea occurs in about 50%, the incidence of postoperative vomiting is about 30%, and in high-risk patients, the PONV rate could be as high as 80%. Therefore, the study design of this single arm, non-randomized, pilot study assessed the efficacy and safety profile of a triple therapy combination with palonosetron, dexamethasone, and promethazine to prevent PONV in patients undergoing craniotomies under general anesthesia.MethodsThe research protocol was approved by the institutional review board and 40 subjects were provided written informed consent. At induction of anesthesia, a triple therapy of palonosetron 0.075 mg IV, dexamethasone 10 mg IV, and promethazine 25 mg IV was given as PONV prophylaxis. After surgery, subjects were transferred to the surgical intensive care unit or post anesthesia care unit as clinically indicated. Ondansetron 4 mg IV was administered as primary rescue medication to subjects with PONV symptoms. PONV was assessed and collected every 24 h for 5 days via direct interview and/or medical charts review.ResultsThe overall incidence of PONV during the first 24 h after surgery was 30% (n = 12). The incidence of nausea and emesis 24 h after surgery was 30% (n = 12) and 7.5% (n = 3), respectively. The mean time to first emetic episode, first rescue, and first significant nausea was 31.3 (±33.6), 15.1 (±25.8), and 21.1 (±25.4) hours, respectively. The overall incidence of nausea and vomiting after 24–120 h period after surgery was 30% (n = 12). The percentage of subjects without emesis episodes over 24–120 h postoperatively was 70% (n = 28). No subjects presented a prolonged QTc interval ≥500 ms before and/or after surgery.ConclusionOur data demonstrated that this triple therapy regimen may be an adequate alternative regimen for the treatment of PONV in patients undergoing neurological surgery under general anesthesia. More studies with a control group should be performed to demonstrate the efficacy of this regimen and that palonosetron is a low risk for QTc prolongation.ClinicalTrials.gov IdentifierNCT02635828 ().

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“…It may be suitable to perform CYP2D6 genotype screening before comparative study of a drug primarily metabolized by CYP2D6 to control the confounders bias. 10 In the end part of the article of Deitrick et al, 1 they suggest that future research should focus on patient characteristics, such as age, gender, and comorbidities. Here, we make an additional supplement that genetic status is also an important patient characteristic to be considered.…”

mentioning

confidence: 99%

Is Promethazine 6.25 mg Intravenous Dose Really Ideal to Treat Postoperative Nausea and Vomiting?

Zhu

Chen

Zhou

2015

Journal of PeriAnesthesia Nursing

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A Comparison of Two Differing Doses of Promethazine for the Treatment of Postoperative Nausea and Vomiting

Cited by 15 publications

References 12 publications

<p>Nurse-Led Randomized Controlled Trials in the Perioperative Setting: A Scoping Review</p>

<p>Nurse-Led Randomized Controlled Trials in the Perioperative Setting: A Scoping Review</p>

The Effect of a Combination Treatment Using Palonosetron, Promethazine, and Dexamethasone on the Prophylaxis of Postoperative Nausea and Vomiting and QTc Interval Duration in Patients Undergoing Craniotomy under General Anesthesia: A Pilot Study

Is Promethazine 6.25 mg Intravenous Dose Really Ideal to Treat Postoperative Nausea and Vomiting?

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