A comparison of vertical and transverse sections in the histological diagnosis of alopecia areata scalp biopsy specimens

Singh, Kanika; Sharma, Sonal; Singh, Usha; Bhattacharya, Sambit

doi:10.4103/0974-7753.188964

Cited by 12 publications

(16 citation statements)

References 14 publications

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“…If the biopsy is not diagnostic, the dermatologist should suspect a hereditary disorder or trauma/injury (mechanical trauma, burn, caustic agent, exposure to radiation, etc.) [64].…”

Section: Scalp Biopsy Resultsmentioning

confidence: 99%

“…In AGA, the biopsy sample contains increased number of miniaturized hairs, abundant enlarged sebaceous glands and minimal inflammation. A ratio of terminal (T) to vellus (v) ratio 3:1 or less is considered to be diagnostic [63,64,65].…”

Section: Scalp Biopsy Resultsmentioning

confidence: 99%

“…Alopecia areata should be suspected when high percentages of telogen hairs are present, even if the peribulbar infiltrate is not present. Both types of AA may sometimes coexist with Androgenetic alopecia [5,9,64].…”

Section: Scalp Biopsy Resultsmentioning

confidence: 99%

“…Some dermatologists consider that both vertical and transverse sections of scalp biopsy specimens are needed. Transverse sections seem to provide a better assessment of the histological features than vertical sections in specimens provided by alopecia areata patients [64]. On the other hand, some dermatopathologists strongly prefer vertical sections, especially in cicatricial alopecias, as they allow the assessment of alopecias associated with interface changes, lichenoid infiltrates and subcutaneous pathology [63].…”

Section: Scalp Biopsy Technique and Requirementsmentioning

confidence: 99%

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Evaluation of Patients with Alopecia

Orăsan¹,

Coneac²,

Roman³

2018

Alopecia

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This chapter outlines the clinical approaches for alopecic patients that are reliable in practice. We discuss three different categories of hair evaluation options: invasive methods (biopsy), semi-invasive methods (trichogram) and noninvasive methods. Besides describing the current status of diagnosis and quantification of alopecia, the chapter provides an objective assessment of these investigation tools: detailed medical history collection by structured interview and questionnaires, clinical examination of the scalp and other hair-bearing areas, laboratory investigations, assessment of hair loss distribution (patterned/diffuse/focal), dermoscopic evaluation, assessment of alopecia severity (by pull test, hair part width, counting hair test), common scales for hair loss staging, photography of alopecic areas, biopsy, trichogram, unit area trichogram, tug test, hair mount and microscopic evaluation, electron microscopy, hair card test, hair weight determination, hair densitometry, mechanical test of hair quality and computed hair analysis. Unfortunately, the disadvantages of most of these methods generate a lack of use in clinical practice, leading to few reliable evaluation methods for patients suffering from alopecia. We underline the necessity of easy, refined and precise evaluation tools for the assessment of alopecia patients.

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“…If the biopsy is not diagnostic, the dermatologist should suspect a hereditary disorder or trauma/injury (mechanical trauma, burn, caustic agent, exposure to radiation, etc.) [64].…”

Section: Scalp Biopsy Resultsmentioning

confidence: 99%

Section: Scalp Biopsy Resultsmentioning

confidence: 99%

Section: Scalp Biopsy Resultsmentioning

confidence: 99%

Section: Scalp Biopsy Technique and Requirementsmentioning

confidence: 99%

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Evaluation of Patients with Alopecia

Orăsan¹,

Coneac²,

Roman³

2018

Alopecia

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“…After the paraffin was fully immersed in the tissue block, pour the hexagonal paraffin into the tissue and quickly clip the paraffin-soaked tissue. After cooling and solidifying into blocks, the sections can be stained [17] .…”

Section: Observation On Transverse Section Of Wolfberry Fruit Tissuementioning

confidence: 99%

The study on the mechanism of “oil-spilling” of wolfberry (Lycium barbarum)fruits during storage

Wang

Xiong

et al. 2018

Preprint

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Improper storage of wolfberry fruit is liable to soften, discoloration and adhesion, we call it "oil-spilling". The purpose of the study is to explore the mechanism of "oil-spilling" of wolfberry fruits during storage. In our study, the relationship between water content, superoxide dismutase (SOD), peroxidase (POD) activity, malondialdehyde (MDA) content and the cross section, epidermal cells of wolfberry fruit were studied during storage. Results showed that wolfberry fruits began to "oil-spilling" on the 20th day, and with the extension of storage time, the degree of "oil-spilling" gradually deepened, the content of water increased and the activity of POD decreased, and the content of MDA increased. It suggested that "oilspilling" was the result of improper external storage conditions, which it could promote the increase of water content and reactive oxygen free radical of wolfberry fruit, and lead to damage of cell structure and function and lipid peroxidation of cell membrane. The results explain the mechanism of "oil-spilling" and provide a strong basis for the establishment of scientific storage methods of wolfberry fruit.

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