A comparison study of Dexmedetomidine Vs Clonidine for sympathoadrenal response, perioperative drug requirements and cost analysis

Panda, Bijoy Kumar; Singh, Priyanka; Marne, Sourabh; Pawar, Atmaram; Keniya, Varshali M; Ladi, Sushma; Swami, Sarita S

doi:10.1016/s2222-1808(12)60271-0

Cited by 15 publications

(12 citation statements)

References 18 publications

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“…When clonidine and dexmedetomidine used in dose 1 mcg /kg iv and compared, both showed significant reduction in myocardial contractility during laryngoscopy and intubation (Panda BK et al). 12 In our study clonidine and dexmedetomidine in dose 1ug/kg diluted to 20 ml with normal saline and given intravenously over a period of 10 min.…”

Section: Discussionmentioning

confidence: 91%

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A comparative study between clonidine and dexmedetomidine in attenuation of pressor response during endotracheal intubation

2020

IJCA

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Aims: 1.To study and compare efficiency of clonidine and dexmedetomidine to reduce haemodynamic response i.e. attenuation of pressor response to laryngoscopy and tracheal intubation with single premedication dose. 2. To evaluate dose sparing effect of clonidine and dexmedetomidine on induction agent Materials and Methods: 60 patients physical status ASA grade I and II were randomized into two groups: C and D (n = 30 in each group). Group C received 1µg/kg of clonidine while group D received 1µg/kg of dexmedetomidine preoperatively over 10 minutes before induction through syringe infusion pump. Each patient was induced with injection Thiopentone sodium until loss of eyelash reflex. After check ventilation succinylcholine 2 mg/kg was given followed by tracheal intubation. Anaesthesia was maintained with O 2 + N 2 O(50:50) and Vecuronium supplemented with isoflurane. Hemodynamic parameters were recorded. Results: We observed no statistical difference in heart rate, blood pressure (systolic, diastolic and mean arterial pressure) between the two groups from baseline up to induction between two groups. Group C had higher readings of HR, SBP, DBP and MAP compared to group D after intubation upto 3 min which was statistically significant. Induction dose of thiopentone was lower in dexmedetomidine group and was statistically significant Conclusion: Dexmedetomidine attenuated the hemodynamic pressor response and also reduces the dose requirement of thiopentone sodium and was superior to clonidine

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Section: Discussionmentioning

confidence: 91%

“…Though dexmedetomidine is costly compared to clonidine, it significantly reduces drug requirement of anaesthetic agent with better haemodynamic blunting response to laryngoscopy and intubation 12 .…”

Section: Discussionmentioning

confidence: 99%

A comparative study between clonidine and dexmedetomidine in attenuation of pressor response during endotracheal intubation

2020

IJCA

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“…There was a significant reduction in the Heart rate and Systolic blood pressure during intubation. In the year 2012, Panda 11 used the infusion of Dexmedetomidine and Clonidine in the doses of 1 µg/kg in 100 mL normal saline 10 minutes before induction. Dexmedetomidine showed a significant decrease in Heart rate and Systolic blood pressure compared to Clonidine.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Dexmedetomidine and Clonidine as Premedicant on Intraocular Pressure and Haemodynamic Changes in Non-Ophthalmic Surgeries

Yadav¹,

Pareek²,

Sharma³

2016

jemds

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“…Few studies had compared clonidine to dexmedetomidine. [ 20 ] A prospective observational study conducted by Panda et al . had compared clonidine, dexmedetomidine (1 μg/kg/10 min through infusion pump preinduction) and a control group.…”

Section: Discussionmentioning

confidence: 99%

Effect of clonidine versus dexmedetomidine on pain control after laparoscopic gastric sleeve: A prospective, randomized, double-blinded study

et al. 2014

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Background:The use of opioids in surgeries for morbidly obese patients could cause respiratory depression. Therefore, alternative analgesics are needed to improve anesthetic management for obese patients. The objective of this study was to compare the effect of dexmedetomidine and clonidine on pain as well as analgesic consumption at 24 h postoperatively in patients undergoing laparoscopic gastric sleeve. The secondary objective was to compare patients’ and surgeons’ satisfaction.Materials and Methods:A total of 60 obese and morbidly obese patients scheduled to undergo laparoscopic gastric sleeve were randomly assigned into two groups. 10 min after induction of general anesthesia, one group received 0.8-1.2 μg/kg/30 min intravenous (IV) clonidine through 500 mL lactated Ringer's solution and placebo (normal saline solution) through syringe pump. The second group received IV dexmedetomidine through syringe pump at a rate 0.5-0.8 μg/kg/h and placebo through 500 mL lactated Ringer's solution. Data on pain, analgesic consumption, and return to normal activity in addition to patients’ and surgeons’ satisfaction were collected.Results:Both groups were similar with respect to demographic and intraoperative hemodynamic characteristics. Fentanyl consumption, surgery duration and hospital stay were similar for the two groups. Pain scores on walking were significantly lower in the clonidine group at 12 h postoperatively (P = 0.014) compared with dexmedetomidine group. The number of patients who consumed pethidine was significantly lower in the clonidine group at 12 h postoperatively (P = 0.045).Conclusion:This study concluded that clonidine and dexmedetomidine yielded similar outcomes with a difference in pain and analgesic consumption at 12 h postoperatively.

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A comparison study of Dexmedetomidine Vs Clonidine for sympathoadrenal response, perioperative drug requirements and cost analysis

Cited by 15 publications

References 18 publications

A comparative study between clonidine and dexmedetomidine in attenuation of pressor response during endotracheal intubation

A comparative study between clonidine and dexmedetomidine in attenuation of pressor response during endotracheal intubation

A Comparative Study of Dexmedetomidine and Clonidine as Premedicant on Intraocular Pressure and Haemodynamic Changes in Non-Ophthalmic Surgeries

Effect of clonidine versus dexmedetomidine on pain control after laparoscopic gastric sleeve: A prospective, randomized, double-blinded study

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