“…This trial was also in compliance with the International Guiding Principles for Biomedical Research Involving Animals, on the basis of the protocol recommended by the International Organization for Standardization (ISO 7405-1994: Biological evaluation of dental materials) (23). The operatory procedures were similar to previous studies (19,24). Two 1-year-old healthy beagle dogs weighing between 25 and 30 kg from the same litter were selected.…”
Section: Root Canal Preparationmentioning
confidence: 99%
“…In casual disagreements, the examiners came to a consensus. The 10 histologic parameters evaluated (Tables 1 and 2) were based on previous studies (14,19,24).…”
“…This trial was also in compliance with the International Guiding Principles for Biomedical Research Involving Animals, on the basis of the protocol recommended by the International Organization for Standardization (ISO 7405-1994: Biological evaluation of dental materials) (23). The operatory procedures were similar to previous studies (19,24). Two 1-year-old healthy beagle dogs weighing between 25 and 30 kg from the same litter were selected.…”
Section: Root Canal Preparationmentioning
confidence: 99%
“…In casual disagreements, the examiners came to a consensus. The 10 histologic parameters evaluated (Tables 1 and 2) were based on previous studies (14,19,24).…”
“…One of these sealers is AH Plus (Dentsply Maillefer, Ballaigues, Switzerland), which has been extensively evaluated for its physicochemical properties and biological response (8,9). There are other epoxy resin-based sealers commercially available.…”
“…Although root fillings are designed to be contained within the canal spaces (3), sealers may be expressed into the periradicular tissues during procedural errors or with the adoption of certain filling techniques, resulting in tissue irritation and delayed healing (4). Contemporary root canal sealers exhibit a variable degree of cytotoxicity depending on the conditions under which they were tested (5,6).…”
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