A competitive nature-derived multilayered scaffold based on chitosan and alginate, for full-thickness wound healing

Vakilian, Saeid; Jamshidi-Adegani, Fatemeh; Yahmadi, Afra Al; Al-Broumi, Mohammed; Rehman, Najeeb Ur; Anwar, Muhammad U.; Alam, Khurshid; Alwahaibi, Nasar; Shalaby, Asem; Alyaqoobi, Sausan; Al‐Harrasi, Ahmed; Mustafa, Kamal; Al-Hashmi, Sulaiman

doi:10.1016/j.carbpol.2021.117921

Cited by 26 publications

(9 citation statements)

References 42 publications

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“…Results indicated that the cytotoxicity of Nio-Tyro was lowered when it was loaded into the CS–AL scaffolds. Fortunately, many investigations have exhibited that AL and CS were noncytotoxic, biodegradable, and biocompatible. , …”

Section: Resultsmentioning

confidence: 99%

RETRACTED: 3D Printing of Alginate/Chitosan-Based Scaffold Empowered by Tyrosol-Loaded Niosome for Wound Healing Applications: In Vitro and In Vivo Performances

Beram,

Ali,

Mesbahian

et al. 2024

ACS Appl. Bio Mater.

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spinning and 3D printing techniques for wound healing applications. The niosomes, measuring 185.40 ± 6.40 nm with a polydispersity index of 0.168 ± 0.012, encapsulated tyrosol with an efficiency of 77.54 ± 1.25%. The scaffold's microsized porous structure (600−900 μm) enhances water absorption, promoting cell adhesion, migration, and proliferation. Mechanical property assessments revealed the scaffold's enhanced resilience, with niosomes increasing the compressive strength, modulus, and strain to failure, indicative of its suitability for wound healing. Controlled tyrosol release was demonstrated in vitro, essential for therapeutic efficacy. The scaffold exhibited significant antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus, with substantial biofilm inhibition and downregulation of bacterial genes (ndvb and icab). A wound healing assay highlighted a notable increase in MMP-2 and MMP-9 mRNA expression and the wound closure area (69.35 ± 2.21%

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Section: Resultsmentioning

confidence: 99%

RETRACTED: 3D Printing of Alginate/Chitosan-Based Scaffold Empowered by Tyrosol-Loaded Niosome for Wound Healing Applications: In Vitro and In Vivo Performances

Beram,

Ali,

Mesbahian

et al. 2024

ACS Appl. Bio Mater.

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“…Furthermore, the group treated with the amikacin‐based films had thicker granulation tissue at the end of the experiment 69 . Increased fibroblast differentiation and reduced inflammatory process indicated the effectiveness of the wound dressings, which showed that the association between PVA/SA/Amicacin was promising for wound treatment 92 …”

Section: Alginate and Pva: Physicochemical Characterization And Biome...mentioning

confidence: 95%

“…PVA and sodium alginate (SA) dried film (B), swollen film (C), and polymer chains dispersed in water (D) inflammatory process indicated the effectiveness of the wound dressings, which showed that the association between PVA/SA/Amicacin was promising for wound treatment. 92 A wound model was studied using albino Wistar rats of both sexes with films of PVA/SA/TiO 2 and curcumin (Cur), a commercial ointment called Mupimet (positive control). 64 Greater wound contraction was observed in the films PVA/SA/TiO 2 -CUR than in the control group, in addition, to complete restoration of damaged skin at the end of the experiment (16th day) qualitatively.…”

Section: Wound Healing Activity Of Alginate/pva Composite Filmsmentioning

confidence: 99%

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

et al. 2022

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The skin is the largest organ in the human body and its physical integrity must be maintained for body homeostasis and to prevent the entry of pathogenic microorganisms. Sodium alginate (SA) and polyvinyl alcohol (PVA) are two polymers widely used in films for wound dressing applications. Furthermore, blends between SA and PVA improve physical, mechanical and biological properties of the final wound healing material when compared to the individual polymers. Different drugs have been incorporated into SA/PVA-based films to improve wound healing activity. It is noteworthy that SA/PVA films can be crosslinked with Ca 2+ or other agents, which improves physicochemical and biological properties. Thus, SA/PVA associations are promising for the biomedical field, as a potential alternative for wound treatment. This review focuses on the main techniques for obtaining SA/PVA films, their physical-chemical characterization, drug incorporation, and the advantages and challenges of these films for wound healing.

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“…Multilayered scaffolds are mostly fabricated through 3D printing, electrospinning, lyophilization technologies ( Fu et al, 2020 ). The complex hierarchical scaffolds loaded with growth factors (e.g., VEGF) or therapeutic drugs (e.g., antibacterial agents) can thus promote angiogenesis and granulation ( Xie et al, 2013 ), cell proliferation and migration, as well as collagen deposition and epithelialization ( Vakilian et al, 2021 ). Though multilayered scaffolds have become a promising approach to treat injuries, overengineered complex scaffolds may be avoided, which could compromise their therapeutic efficacy and make the manufacture challenging.…”

Section: The Philosophy Of Wound Healing Scaffoldsmentioning

confidence: 99%

Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing

Qin

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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Wound healing is an evolved dynamic biological process. Though many research and clinical approaches have been explored to restore damaged or diseased skin, the current treatment for deep cutaneous injuries is far from being perfect, and the ideal regenerative therapy remains a significant challenge. Of all treatments, bioengineered scaffolds play a key role and represent great progress in wound repair and skin regeneration. In this review, we focus on the latest advancement in biomaterial scaffolds for wound healing. We discuss the emerging philosophy of designing biomaterial scaffolds, followed by precursor development. We pay particular attention to the therapeutic interventions of bioengineered scaffolds for cutaneous wound healing, and their dual effects while conjugating with bioactive molecules, stem cells, and even immunomodulation. As we review the advancement and the challenges of the current strategies, we also discuss the prospects of scaffold development for wound healing.

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A competitive nature-derived multilayered scaffold based on chitosan and alginate, for full-thickness wound healing

Cited by 26 publications

References 42 publications

RETRACTED: 3D Printing of Alginate/Chitosan-Based Scaffold Empowered by Tyrosol-Loaded Niosome for Wound Healing Applications: In Vitro and In Vivo Performances

RETRACTED: 3D Printing of Alginate/Chitosan-Based Scaffold Empowered by Tyrosol-Loaded Niosome for Wound Healing Applications: In Vitro and In Vivo Performances

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing

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