A complete corticotropin releasing factor system localized in human fetal lung

Chouridou, Efterpi; Lambropoulou, María; Koureta, Maria; Balgouranidou, Ioanna; Nena, Evangelia; Simopoulou, Mara; Παπαδόπουλος, Νικόλαος; Kortsaris, A.; Chatzaki, Εkaterini

doi:10.1007/bf03401337

Cited by 3 publications

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“…This is not surprising, as the presence of CRF neuropeptides 6,11 and receptors 29 has previously been shown in the human adult heart. Moreover, we have recently demonstrated the full CRF system localization in the lungs of normal and pathological human fetuses 31 and suggested a possible role in its development.…”

Section: Discussionmentioning

confidence: 85%

“…In the human, limited information is offered regarding the presence of the CRF system in fetal tissues and its contribution to fetal maturation and/or pathology. Recently we reported the presence of all CRF family members in human fetal lungs during development, 31 while CRFR1 mRNA had previously been found in human fetal adrenals. 32 In animal fetal tissues, studies have reported the presence of CRF family members centrally in the rat and ovine hypothalamus, 33,34 in the ovine pituitary, 35 hippocampal-amygdala complex, frontal cerebral cortex (FCC) and brainstem 36 and in the mouse cerebellum.…”

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confidence: 86%

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Corticotropin-releasing factor (CRF) system localization in human fetal heart

Chouridou

Lambropoulou

Koureta

et al. 2016

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oBJectIVe: the corticotropin-releasing factor (cRf) family consists of the neuropeptides cRf, ucn I, II and III and the binding sites cRfR1, cRfR2 and cRf-BP. It regulates stress response and the homeostasis of an organism. In this study, we examined the presence of the cRf system in the human hearts of normal and pathological fetuses. desIGn: Heart tissues from 40 archival human fetuses were divided into Group A (without pathology, 'normal'), Group B (with chromosomal abnormalities) and Group c (with congenital disorders). Immunohistochemistry was used to localize the cRf system. Results correlated to gestational trimester and pathology. ResuLts: Immunoreactivity for all antigens was found in cardiac myocytes of all groups, in almost all samples, except ucn III which was present in almost half of the fetuses of Groups B and c and was not detected at all in Group A. ucn III was more often present during the earlier stage of development (<21weeks) and in fetuses with congenital disorders. In a fetus diagnosed with heart pathology, all but ucn III antigens were also present. concLusIons: we localized a complete cRf system in the human fetal heart and correlated the presence of ucn III to development and pathology. More studies are needed to verify and clarify the exact role of the cRf system in the human fetal heart.

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