A composite lymphoma combining a Hodgkin lymphoma and a marginal zone lymphoma transformed into a diffuse large B‐cell lymphoma

Auditeau, Claire; Lambotte, Olivier; Feriel, Joffrey; Lazure, Thierry; Turhan, Ali G; Aumont, Cédric

doi:10.1002/ccr3.1841

Cited by 3 publications

(5 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Transformation to DLBCL was observed in 17 cases, which is in accordance with previous studies with similar follow‐up times 4,16 although somewhat lower than in one other study 3 . In addition, we report four cases of HL, which is an unusual finding, although this has previously been observed in rare cases 5 …”

Section: Discussionsupporting

confidence: 92%

“…3 In addition, we report four cases of HL, which is an unusual finding, although this has previously been observed in rare cases. 5 HCV and HBV infection or reactivation did not appear to be a contributing factor to the course of SMZL in this Swedish cohort, since none of the patients were diagnosed with active HCV or HBV infection. Up to 35% of SMZL patients in previous studies have been infected with HCV.…”

Section: Discussionmentioning

confidence: 60%

“…At onset, the disease is often disseminated while patients are usually asymptomatic, rarely exhibit B symptoms and have good performance status according to the Eastern Cooperative Oncology Group (ECOG) score. 1,2 A more aggressive disease course is seen in approximately 30% and transformation to high grade lymphomas is observed in 5-10% [3][4][5] of cases.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Superior outcome for splenectomised patients in a population‐based study of splenic marginal zone lymphoma in Sweden

et al. 2021

View full text Add to dashboard Cite

Splenic marginal zone lymphoma (SMZL) is a rare low-grade B-cell lymphoma where associations with viral hepatitis and autoimmune and inflammatory diseases (AID) have been indicated. We aimed at assessing the prevalence of viral hepatitis and AID at SMZL diagnosis and outcome by treatment in a Swedish population-based study. A total of 277 SMZL patients registered in the Swedish Lymphoma Register in 2007-2017 were included. A history of viral hepatitis was reported in five (2%) patients and AID prior to SMZL in 72/240 (30%) patients. Treatment was given up front for 207 (75%) patients. Splenectomy with or without systemic treatment was performed in 119 (57%) and was associated with statistically significantly better overall survival [hazard ratio, HR = 0Á47 (95% confidence interval, CI: 0Á23-0Á93), P = 0Á03] and progression-free survival (HR = 0Á55, 95% CI: 0Á35-0Á86, P = 0Á008) compared to non-splenectomised patients in multivariable analyses. The up-front splenectomised group was younger and generally had a lower Ann Arbor stage, but also more frequently B symptoms and high lactate dehydrogenase than the non-splenectomised group. Viral hepatitis and AID history did not affect SMZL outcome. We report high incidence of AIDs and low incidence of viral hepatitis in this population-based study of SMZL. Splenectomy up front was associated with a favourable outcome.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Superior outcome for splenectomised patients in a population‐based study of splenic marginal zone lymphoma in Sweden

et al. 2021

View full text Add to dashboard Cite

show abstract

“…A total of 21 cHL/marginal zone composite lymphomas from 10 articles were analyzed [ 6 , 60 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 ].…”

Section: Resultsmentioning

confidence: 99%

“…A total of 79 cHL/diffuse large B-cell composite lymphomas from 35 articles were analyzed [ 1 , 3 , 6 , 13 , 14 , 16 , 58 , 64 , 66 , 76 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 ].…”

Section: Resultsmentioning

confidence: 99%

Plasticity in Classical Hodgkin Composite Lymphomas: A Systematic Review

Trécourt

Donzel

Fontaine

et al. 2022

Cancers

View full text Add to dashboard Cite

The co-occurrence of several lymphomas in a patient defines composite/synchronous lymphoma. A common cellular origin has been reported for both contingents of such entities. In the present review, we aimed to gather the available data on composite lymphomas associating a classical Hodgkin lymphoma (cHL) with another lymphoma, to better understand the plasticity of mature B and T-cells. This review highlights that >70% of patients with a composite lymphoma are ≥55 years old, with a male predominance. The most reported associations are cHL with follicular lymphoma or diffuse large B-cell lymphoma, with over 130 cases reported. The cHL contingent is often of mixed cellularity type, with a more frequent focal/weak CD20 expression (30% to 55.6%) compared to de novo cHL, suggesting a particular pathophysiology. Moreover, Hodgkin cells may express specific markers of the associated lymphoma (e.g., BCL2/BCL6 for follicular lymphoma and Cyclin D1 for mantle cell lymphoma), sometimes combined with common BCL2/BCL6 or CCND1 rearrangements, respectively. In addition, both contingents may share similar IgH/IgK rearrangements and identical pathogenic variants, reinforcing the hypothesis of a common clonal origin. Finally, cHL appears to be endowed with a greater plasticity than previously thought, supporting a common clonal origin and a transdifferentiation process during lymphomagenesis of composite lymphomas.

show abstract

PD-1 Tumor Suppressor Signaling in T Cell Lymphomas

Wartewig

Ruland

2019

Trends in Immunology

View full text Add to dashboard Cite

A composite lymphoma combining a Hodgkin lymphoma and a marginal zone lymphoma transformed into a diffuse large B‐cell lymphoma

Cited by 3 publications

References 14 publications

Superior outcome for splenectomised patients in a population‐based study of splenic marginal zone lymphoma in Sweden

Superior outcome for splenectomised patients in a population‐based study of splenic marginal zone lymphoma in Sweden

Plasticity in Classical Hodgkin Composite Lymphomas: A Systematic Review

PD-1 Tumor Suppressor Signaling in T Cell Lymphomas

Contact Info

Product

Resources

About