A comprehensive evaluation of serum autoantibodies in primary biliary cirrhosis

Agmon‐Levin, Nancy; Shapira, Yinon; Selmi, Carlo; Barzilai, Ori; Ram, Maya; Szyper‐Kravitz, Martine; Sella, Sara; Katz, Bat Sheva Porat; Youinou, Pierre; Renaudineau, Yves; Larida, Bruno; Invernizzi, Pietro; Gershwin, M. Eric; Shoenfeld, Yehuda

doi:10.1016/j.jaut.2009.08.009

Cited by 91 publications

(49 citation statements)

References 31 publications

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“…24 No 1: [25][26][27][28][29][30][31][32][33][34] mechanism [8,9]. Although classically considered as distinct entities, these autoimmune liver diseases (AiLD) may share biochemical and immunological features [9,10], such as the positivity of specific autoantibodies [11,12], that plays a central role in the diagnosis and classification of AiLD [13].…”

Section: Introductionmentioning

confidence: 99%

Autoimmune Liver Diseases and Antiphospholipid Antibodies Positivity: a Meta-analysis of Literature Studies

Ambrosino

Lupoli

Spadarella

et al. 2015

JGLD

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Background & Aims: Several studies reported an association between autoimmune liver diseases (AiLD) and antiphospholipid antibodies (aPL) positivity. We performed a meta-analysis of studies evaluating the association of primary biliary cirrhosis (PBC), autoimmune hepatitis (AIH), and primary sclerosing cholangitis (PSC) with aPL positivity and with aPL-related thrombotic events.Methods: Studies evaluating the association of AiLD with aPL (anticardiolipin [aCL], anti-β2 glycoprotein-I [anti-β2GPI], lupus anticoagulant [LA] antibodies) and with aPL-related thrombotic complications were systematically searched in the PubMed, Web of Science, Scopus and EMBASE databases.Results: A total of 10 studies (750 patients with AiLD and 1,244 healthy controls) were included in the analysis on the prevalence of aPL and showed that AiLD are significantly associated with the presence of aCL and anti-β2GPI. The association with aCL positivity was consistently confirmed in PBC (OR: 13.93, 95%CI: 4.69-41.38), AIH (OR: 23.50, 95%CI: 4.28-129.13), and PSC (OR: 18.21, 95%CI: 7.05-47.08). Similarly, anti-β2GPI were found more frequently in PBC (OR: 25.10, 95%CI: 4.77-132.11), AIH (OR: 48.57, 95%CI: 11.07-213.09), and PSC (OR: 36.30, 95%CI: 6.55-201.31). These findings are confirmed when separately analyzing IgM, IgG, and IgA directed against phospholipids. Two of the 10 included articles and 1 further study (67 cases and 75 controls) showed a trend - not achieving statistical significance - towards a higher prevalence of thrombotic complications in AIH patients with aPL as compared to those with only AIH (OR: 1.67, 95%CI: 0.46-6.05).Conclusion: PBC, AIH, and PSC are significantly associated with aPL positivity. The association with aPL-related thrombotic complications should be further studied.

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Section: Introductionmentioning

confidence: 99%

Autoimmune Liver Diseases and Antiphospholipid Antibodies Positivity: a Meta-analysis of Literature Studies

Ambrosino

Lupoli

Spadarella

et al. 2015

JGLD

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“…In humans, production of autoantibodies (a-Abs) against self-antigens is frequent and it was thought that a-Abs are associated with autoimmune diseases but increased level of serum a-Abs have been documented in non-autoimmune disorders i.e. complicated pregnancy, cancer, stroke etc 2,3,4 . Low level of natural a-Abs are present in healthy individuals 5 but their level varies with age, physical loads, and stress caused by various unfavorable factors.…”

Section: Introductionmentioning

confidence: 99%

“…Antinuclear antibody (ANA) have central role in autoimmunity and it is directed against variety of nuclear antigens. It is found in different autoimmune disorders and in healthy individuals 3,9 but it enables clinicians to predict diagnosis and severity of disease 7,8 . Some members of ANA family of a-Abs may present years before the diagnosis of disease.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Autoantibodies in Healthy Adults in Pakistani Population

Ashraf

Afzal

Kashif

et al. 2016

Bangladesh J Med Sci

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Introduction: Autoimmune phenomenon is attributed to a number of diseases which were once considered idiopathic. In humans, production of auto antibodies (a-Abs) against self-antigens is quite frequent but earlier their presence was associated with autoimmune diseases, however a-Abs have been documented in non-autoimmune disorders i.e. complicated pregnancy, cancer, stroke etc. In Pakistan, limited data is available on frequency of a-Abs, therefore this study was designed to determine serum level of antinuclear antibody (ANA), Rheumatoid factor (RF) and anti dsDNA antibodies in apparently healthy population. Materials and methods: After written informed consent, blood sample of 256 subjects was obtained by random sampling. Participants of established autoimmune diseases were excluded. Enzyme linked immunosorbent assay (ELISA) was used to determine ANA, RF and anti-dsDNA antibody. Categorical variables were compared by using χ 2 test. A p value <0.05 was considered statistically significant. Results: Rheumatoid factor was the most frequent a-Ab (18%), followed by anti dsDNA (7.4%), while ANA was the lowest (0.4%) antibody detected. Only RF had a statistically significant association with gender (p=0.047). No association of these antibodies with age was detected. Conclusion: Rheumatoid factor auto antibody was more prevalent as compared to ANA and dsDNA antibody in healthy adults.

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“…Detection of anti-cellular antibodies of the ANA family is pivotal to the diagnosis of many autoimmune disease. 1,2 ANA are a specific class of autoantibodies that have the capability of binding and…”

Section: Introductionmentioning

confidence: 99%

Anti-Nuclear antibodies: Current concepts and future direction for diagnosing connective tissue disease

Gautam¹

2015

J Pathol Nep

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Identification of antinuclear antibodies has been used for the diagnosis of connective tissue diseases for more than fifty years. Indirect immunofluorescence on human epithelial (HEp-2) cells is considered the gold standard screening method for the detection of antinuclear autoantibodies. As the demand of ANA testing increased, the need for automation and standardization has also come forth. A high level of false positive and false negative cases is seen in various populations making it difficult to take clinical decisions. Newer technologies were introduced for the antibody detection to ensure high sensitivity and specificity. This article intends to provide an overview of the concepts on ANA testing, the different diagnostic methods available, the various patterns and clinical utility, the clinical guidelines to be followed, the drawbacks and what lies ahead in the future of ANA testing.

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A comprehensive evaluation of serum autoantibodies in primary biliary cirrhosis

Cited by 91 publications

References 31 publications

Autoimmune Liver Diseases and Antiphospholipid Antibodies Positivity: a Meta-analysis of Literature Studies

Autoimmune Liver Diseases and Antiphospholipid Antibodies Positivity: a Meta-analysis of Literature Studies

Prevalence of Autoantibodies in Healthy Adults in Pakistani Population

Anti-Nuclear antibodies: Current concepts and future direction for diagnosing connective tissue disease

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