A Comprehensive Guide to Sperm Recovery in Infertile Men with Retrograde Ejaculation

Gupta, Sajal; Sharma, Rakesh; Agarwal, Ashok; Parekh, Neel; Finelli, Renata; Shah, Rupin; Kandil, Hussein; Saleh, Ramadan; Arafa, Mohamed; Ko, Edmund; Simopoulou, Mara; Zini, Armand; Rajmil, Osvaldo; Kavoussi, Parviz K.; Singh, Keerti; Ambar, Rafael F.; Elbardisi, Haitham; Sengupta, Pallav; Martínez, Marlon; Boitrelle, Florence; Alves, Marco G.; Khalafalla, Kareim; Roychoudhury, Shubhadeep; Busetto, Gian Maria; Gosálvez, Jaime; Tadros, Nicholas N.; Palani, Ayad; Rodriguez, Marcelo Gabriel; Anagnostopoulou, Christina; Mićić, Sava; Rocco, Lucia; Mostafa, Taymour; Álvarez, Juan G.; Jindal, Sunil; Sallam, Hassan; Rosas, Israel Maldonado; Lewis, Sheena; Alsaid, Sami; Altan, Mesut; Park, Hyun Jun; Ramsay, Jonathan; Parekattıl, Sıjo J.; Sabbaghian, Marjan; Tremellen, Kelton; Vogiatzi, Paraskevi; Gilani, Mohammad Ali Sadighi; Evenson, Donald P.; Colpi, Giovanni M.

doi:10.5534/wjmh.210069

Cited by 12 publications

(6 citation statements)

References 35 publications

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“…Table 2 [ 3 22 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 ] illustrates that 23 articles were published in prestigious peer-reviewed journals by author contributions representing 46 countries. Broadly classified, these articles tackled contemporary challenges in andrology spanning across topics of sperm DNA damage, semen analysis, laboratory issues in relation to assisted reproductive technique (ART), sperm recovery, etc.…”

Section: Resultsmentioning

confidence: 99%

The Global Andrology Forum (GAF): Structure, Roles, Functioning and Outcomes: An Online Model for Collaborative Research

Ansari

Savira

Atmoko

et al. 2024

World J Mens Health

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Purpose There are no published examples of a global online research collaborative in andrology. We describe the development, profile and member characteristics of the first consortium of this type, the Global Andrology Forum (GAF). Materials and Methods An online survey sent to all GAF members collected demographic information (sex, age, experience, academic title, degrees, country, specialty, profession). It also tapped data on members’ characteristics e.g., skills in research, software and statistics; preferred activities; time commitments; expected roles; and interest in participating in research, in GAF’s scientific activities and collaborative online research. The findings were analyzed and tabulated. We outline members’ demographic and professional characteristics and scientific achievements to date. A narrative approach outlined GAF’s structure and functioning. Results A total of 418 out of 540 members completed the survey and were included in the analysis (77.4% response rate). The sample comprised mainly urologists (34.2%) and a third of the respondents had practiced for >15 years (33.3%). Up to 86.1% of the members expressed interest in being actively engaged in writing scientific articles. A third of the sample (37.1%) could dedicate 4 to 6 hours/week. Few respondents reported skills in statistics and artwork (2.6% and 1.9% respectively). Members were assigned to specific roles based on their expertise and experiences. Collaborative working ensured the timely completion of projects while maintaining quality. For outcomes, GAF published 29 original articles within one year of its creation, with authors from 48 countries spanning topics that included varicocele, sperm DNA damage, oxidative stress, semen analysis and male infertility, oocyte/embryo, and laboratory issues of assisted reproductive technique (ART) and male infertility evaluation. Conclusions GAF is a successful global online andrology research model. A healthy number of scientific articles have been published. Given such effectiveness, adopting the GAF model could be useful for other disciplines that wish to create and coordinate successful international online research groups.

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Section: Resultsmentioning

confidence: 99%

The Global Andrology Forum (GAF): Structure, Roles, Functioning and Outcomes: An Online Model for Collaborative Research

Ansari

Savira

Atmoko

et al. 2024

World J Mens Health

Self Cite

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“…For those pubertal males whose testes are mature enough to produce sperm but are unable to produce an adequate semen sample for banking secondary to ejaculatory or other disorders, consideration should be made for other ways of collecting a sample, pre or post therapy. This includes urine collection in retrograde ejaculation, 36 or other techniques including testicular sperm aspiration (TESA) or testicular sperm extraction (TESE) with or without microdissection. 37 Consideration must be given to radiation therapy, as the field and dose may alter the risk estimate and is additive to chemotherapy exposures.…”

Section: Discussionmentioning

confidence: 99%

Fertility preservation in pediatric solid tumors: A report from the Children's Oncology Group

Bjornard,

Close,

Burns

et al. 2024

Pediatric Blood & Cancer

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Treatment for childhood solid tumors may lead to an increased risk for gonadal dysfunction/infertility. Discussion of risk should occur at diagnosis, any changes in therapy, and during survivorship. Gonadotoxic therapies were abstracted from 32 Children's Oncology Group (COG) phase III, frontline solid tumor protocols, in use from 2000 to 2022. Risk for gonadal dysfunction/infertility was assessed based on gonadotoxic therapies, sex, and pubertal status and assigned as minimal, significant, and high following the Oncofertility Consortium Pediatric Initiative Network (PIN) risk stratification. Most protocols (65.6%, 21/32) contained at least one therapeutic arm with a high level of increased risk. Solid tumor therapies present challenges in risk stratification due to response‐adjusted therapy and the need to account for radiation field in the risk assessment. This guide hopes to serve as a tool to assist in standardizing gonadotoxic risk assessments across disciplines and improve referral for fertility services and reproductive health counseling for patients receiving COG‐based solid tumor therapy. Internationally, many solid tumor therapies follow similar paradigms to COG studies, and risk stratifications may be generalizable to similar styles of therapy. In addition, this model may be applied to other international groups with the goal of standardizing fertility assessments.

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“…87 Another approach for treating retrograde ejaculation involves alkalization of urinary pH to preserve sperm viability. 88 Namely, retrograde ejaculation can be treated using sodium bicarbonate, sodium citrate, or potassium bicarbonate, as the acidity and osmolarity of urine has toxic effects on sperm. 89 Additionally, there has been success in restoring antegrade ejaculation in patients by injecting Deflux, a gel composed of dextranomer and hyaluronic acid typically used to treat vesicoureteral reflux in pediatric patients, into the transurethral bladder neck.…”

Section: Restoration Of Ejaculatory Function Retrograde Ejaculationmentioning

confidence: 99%

“…Another approach for treating retrograde ejaculation involves alkalization of urinary pH to preserve sperm viability 88 . Namely, retrograde ejaculation can be treated using sodium bicarbonate, sodium citrate, or potassium bicarbonate, as the acidity and osmolarity of urine has toxic effects on sperm 89 .…”

Section: Restoration Of Ejaculatory Functionmentioning

confidence: 99%

The erectile and ejaculatory implications of the surgical management of rectal cancer

Ghomeshi,

Zizzo,

Reddy

et al. 2023

Int J of Urology

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Colorectal cancer is a significant cause of cancer‐related deaths worldwide. Although advances in surgical technology and technique have decreased mortality rates, surviving patients often experience sexual dysfunction as a common complication. The development of the lower anterior resection has greatly decreased the use of the radical abdominoperineal resection surgery, but even the less radical surgery can result in sexual dysfunction, including erectile and ejaculatory dysfunction. Improving the knowledge of the underlying causes of sexual dysfunction in this context and developing effective strategies for preventing and treating these adverse effects are essential to improving the quality of life for postoperative rectal cancer patients. This article aims to provide a comprehensive evaluation of erectile and ejaculatory dysfunction in postoperative rectal cancer patients, including their pathophysiology and time course and strategies for prevention and treatment.

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A Comprehensive Guide to Sperm Recovery in Infertile Men with Retrograde Ejaculation

Cited by 12 publications

References 35 publications

The Global Andrology Forum (GAF): Structure, Roles, Functioning and Outcomes: An Online Model for Collaborative Research

The Global Andrology Forum (GAF): Structure, Roles, Functioning and Outcomes: An Online Model for Collaborative Research

Fertility preservation in pediatric solid tumors: A report from the Children's Oncology Group

The erectile and ejaculatory implications of the surgical management of rectal cancer

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