2018
DOI: 10.1016/j.ajme.2017.02.002
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A comprehensive in vitro biological investigation of metal complexes of tolfenamic acid

Abstract: Objective: The inquisitive objective of the study was to observe the antimicrobial, cytotoxicity, and antioxidant activities of some newly synthesized metal complexes of tolfenamic acid. Methods: While antimicrobial activity was studied by disk diffusion method, cytotoxicity was studied by performing brine shrimp lethality bioassay. Moreover, DPPH radical scavenging potential was observed to determine the antioxidant property of the complexes. Results: From the disk diffusion antimicrobial screening of tolfena… Show more

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Cited by 6 publications
(2 citation statements)
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“…Cells of both cell lines died with all the compounds at concentrations of 500 and 250 µM, but cell viability was not affected at concentrations of 50 and 5 µM, with the exception of the compound Ag-T, which reduced the viability of fibroblast cells by 50% at a concentration of 50 µM. However, in comparison with other tolfenamic metals (Cu, Co, and Zn), the silver compounds are less toxic [ 36 ]. These results can be explained by reference to other investigations that have shown the cytotoxic effects of tolfenamic acid [ 37 ] on the proliferation of nasopharyngeal cancer cell lines and a normal keratinocyte cell line.…”
Section: Resultsmentioning
confidence: 99%
“…Cells of both cell lines died with all the compounds at concentrations of 500 and 250 µM, but cell viability was not affected at concentrations of 50 and 5 µM, with the exception of the compound Ag-T, which reduced the viability of fibroblast cells by 50% at a concentration of 50 µM. However, in comparison with other tolfenamic metals (Cu, Co, and Zn), the silver compounds are less toxic [ 36 ]. These results can be explained by reference to other investigations that have shown the cytotoxic effects of tolfenamic acid [ 37 ] on the proliferation of nasopharyngeal cancer cell lines and a normal keratinocyte cell line.…”
Section: Resultsmentioning
confidence: 99%
“…Conjugates of cisplatin and tolfenamic acid (TOLF) assembled in nanoparticles were found to induce apoptosis and decrease metastasis in breast cancer cells in vitro and in vivo [ 60 , 63 , 64 ]. The three anthranilic acid derivatives were already examined for their anticancer activity in metal complexes including nickel(II) [ 65 , 66 , 67 ], copper(II) [ 66 , 67 , 68 , 69 , 70 ], manganese(II) [ 66 , 67 ], cobalt(II) [ 66 , 67 , 69 , 71 ], and zinc(II) [ 66 , 67 , 69 ] and showed promising results interesting for further studies.…”
Section: Introductionmentioning
confidence: 99%