A Comprehensive Insight into the Phytochemical, Pharmacological Potential, and Traditional Medicinal Uses of Albizia lebbeck (L.) Benth.

Abstract

Background. Albizialebbeck is a deciduous tree having tremendous medicinal utilities, for example, respiratory, skin, gastrointestinal, oral disorders, eye, urinary, genital, anorectal, inflammatory, and neurological disorders, and venereal diseases. Several studies have been undertaken on the medicinal and traditional values of A. lebbeck. Objective. The detailed information about its medicinal uses and pharmacological implications is highly scattered and distributed in different data sources. Hence, the study was conducted to supply an inclusive review of its ethnomedicinal uses, phytochemicals, and the available pharmacological attributes supporting its efficiency in traditional medicine. Method. Literature surveys were conducted on this medicinal plant via search engines like Google Scholar, PubMed, and Science Direct, and obtained information up to December 2020 has been assessed and analyzed for this study. Results. Systematic investigation revealed that A. lebbeck consists of various phytochemicals, including major alkaloids, flavonoids, saponins, and terpenoids. Its crude extract, fraction, and bioactive compounds exhibited potent adulticidal, antiallergic, anticancer, anticonvulsant, antidiabetic, antidiarrheal, anti-inflammatory, antimicrobial, antinociceptive, antioxidant, antiparasitic, antipyretic, antivenom, estrogenic, neuroprotective, nootropic, ovicidal, and wound healing activities. Conclusions. This study proposes that A. lebbeck remains a rich source of phytochemicals with various biological activities which possess outstanding therapeutic benefits to humanity across the world. However, studies are required to estimate the potential side effects. Moreover, mechanistic physiognomies of the isolated compounds with known bioactivities are quite limited; thus, forthcoming research needs to focus on the mechanisms of these active phytochemicals to facilitate their potential enrolling for drug discovery.

Ethnoveterinary practises of medicinal plants used for the treatment of different cattle diseases: A case study in East Khasi Hill district of Meghalaya, North East India

“… Triterpenoid saponins (oleonolic acid), ecdysterone, achyranthine, betaine, pentatriaontane, hexatriacontane, tritriacontane [ 32 ] Acorus calamus L. Alpha (α)-asarone, beta (β)-asarone, acoradin, eugenol, β-sitosterol, azulene [ 33 ] Aegle marmelos Correa Marmelosin, aegeline, lupeol, marmin, fagarine, tannin [ 34 ] Albizia lebbeck Benth. Albiziasaponins, lupenone, freidelin, lupeol, β sitosterol- 3-O-glucoside, stigmasterol -3-O-glucoside, luteolin, rutin [ 35 ] Allium cepa L. Organic sulphur, flavonoids, polyphenols [ 36 ] Allium sativum L. Allicin, alliin, diallyl sulfides, ajoene, S-allyl-cysteine [ 37 ] Aloe vera (L.) Burm.f. Anthraquinone, tannin, saponin, flavonoids, terpenoids, octadecanoic acid, tricosane, 1-octadecanol [ 38 ] Alternanthera philoxeroides (Mart.)…”

Mercuric-sulphide based metallopharmaceutical formulation as an alternative therapeutic to combat viral and multidrug-resistant (MDR) bacterial infections

“…Into the wells, 100 μL of the various concentrations (2.5 mg/mL, 5 mg/mL, 10 mg/mL, 15 mg/mL, 20 mg/mL, and 25 mg/mL) of the Sivanar Amirtham samples were aliquoted and the MH agar plates were incubated at 37 °C overnight. The ZOI around the wells was measured in millimeters (mm) at the end of the incubation period and the ability of the formulation to inhibit the growth of bacteria was evaluated 35 .…”

Neuroprotective mechanisms of luteolin in glutamate-induced oxidative stress and autophagy-mediated neuronal cell death

“…Albizia lebbeck, a medicinal plant native to part of Southeast Asia and the Indian subcontinent, and belonging to the Fabaceae family, is recognized for its notable antioxidant, anti-inflammatory, and neuroprotective activities 22 . A. lebbeck contains various phytochemical constituent, which shows promise as a potential therapeutic agent for neurodegenerative diseases 23 , 24 . However, the neuroprotective effect and molecular mechanism of A. lebbeck extract and luteolin against glutamate-induced hippocampal cell death have not been elucidated.…”