A comprehensive insight into the molecular and cellular mechanisms of the effects of Propolis on preserving renal function: a systematic review

Anvarifard, Paniz; Anbari, Maryam; Ostadrahimi, Alireza; Ardalan, Mohammadreza; Ghoreishi, Zohreh

doi:10.1186/s12986-021-00639-z

Cited by 13 publications

(16 citation statements)

References 107 publications

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“…The levels of MDA and thiobarbituric acid-reactive substances (TBARS) are indicative of the extent of ROS-induced damage and are considered important indicators of oxidative stress damage severity. 44 As depicted in Figure 5g, h, the levels of MDA and TBARS in the AKI group treated with PBS were significantly higher compared to those in the normal group (MDA: normal = 23.40 ± 0.86 vs AKI = 44.94 ± 1.52 μmol per mg of protein; TBARS: normal = 1.39 ± 0.12 vs AKI = 2.31 ± 0.08 nmol per mg tissue). Notably, the levels of MDA and TBARS in CeLutNC-treated AKI mice decreased gradually in a dosagedependent manner.…”

Section: In Vivo Effects Of Celutncs On Aki Micementioning

confidence: 82%

“…Similarly, the levels of H 2 O 2 in the kidneys of AKI mice were significantly reduced after CeLutNC treatment, approaching the levels observed in normal mice (Figure f). The levels of MDA and thiobarbituric acid-reactive substances (TBARS) are indicative of the extent of ROS-induced damage and are considered important indicators of oxidative stress damage severity . As depicted in Figure g, h, the levels of MDA and TBARS in the AKI group treated with PBS were significantly higher compared to those in the normal group (MDA: normal = 23.40 ± 0.86 vs AKI = 44.94 ± 1.52 μmol per mg of protein; TBARS: normal = 1.39 ± 0.12 vs AKI = 2.31 ± 0.08 nmol per mg tissue).…”

Section: Results and Discussionmentioning

confidence: 98%

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Cerium–Luteolin Nanocomplexes in Managing Inflammation-Related Diseases by Antioxidant and Immunoregulation

Gu,

Zhang,

et al. 2024

ACS Nano

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Oxidative stress, characterized by an imbalance between reactive oxygen species (ROS) production and the antioxidant defense system, plays a pivotal role in inflammationrelated diseases. Excessive ROS levels can induce cellular damage and impair normal physiological functions, triggering the release of inflammatory mediators and exacerbating the inflammatory response, ultimately leading to irreversible tissue damage. In this study, we synthesized cerium ion−luteolin nanocomplexes (CeLutNCs) by coordinating Ce ions with the natural product luteolin, aiming to develop a therapeutic agent with excellent antioxidant and immunoregulation properties for ROS-related inflammation treatment. In vitro experiments demonstrated that the prepared CeLutNCs effectively scavenged excess ROS, prevented cell apoptosis, downregulated levels of important inflammatory cytokines, regulated the response of inflammatory macrophages, and suppressed the activation of the nuclear factor-κ-gene binding (NF-κB) pathway. In an acute kidney injury (AKI) animal model, CeLutNCs exhibited significant efficacy in improving kidney function, repairing damaged renal tissue, and reducing oxidative stress, inflammatory response, and cellular apoptosis. Moreover, the therapeutic potential of CeLutNCs in an acute lung injury (ALI) model was confirmed through the assessment of inflammatory responses and histopathological studies. This study emphasizes the effectiveness of these metal−natural product coordination nanocomplexes as a promising therapeutic approach for preventing AKI and other diseases associated with oxidative stress.

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Section: In Vivo Effects Of Celutncs On Aki Micementioning

confidence: 82%

Section: Results and Discussionmentioning

confidence: 98%

Cerium–Luteolin Nanocomplexes in Managing Inflammation-Related Diseases by Antioxidant and Immunoregulation

Gu,

Zhang,

et al. 2024

ACS Nano

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“…Increased MTT conversion could be led by either increased cell proliferation or interference in formazan conversion by the treatment. It is already well established that propolis in general, due to its antioxidant properties, plays an important role in mitochondrial protection against oxidative stress, [ 33–93 ] and as an antioxidant, it can interfere with the MTT assay. [ 94,95 ] Hence, the NR dye incorporation assay was performed to determine cell cytotoxicity.…”

Section: Resultsmentioning

confidence: 99%

Preparation and Investigation of Thermally Annealed Zein–Propolis Electrospun Nanofibers for Biomedical Applications

Hochheim

Sampaio

Cruz

et al. 2023

Macromolecular Bioscience

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Zein, a corn‐derived protein, has a variety of applications ranging from drug delivery to tissue engineering and wound healing. This work aims to develop a biocompatible scaffold for dermal applications based on thermally annealed electrospun propolis‐loaded zein nanofibers. Pristine fibers' biocompatibility is determined in vitro. Next, propolis from Melipona quadrifasciata is added to the fibers at different concentrations (5% to 25%), and the scaffolds are studied. The physicochemical properties of zein/propolis precursor dispersions are evaluated and the results are correlated to the fibers' properties. Due to zein's and propolis' very favorable interactions, which are responsible for the increase in the dispersions surface tension, nanometric size ribbon‐like fibers ranging from 420 to 575 nm are obtained. The fiber's hydrophobicity is not dependent on propolis concentration and increases with the annealing procedure. Propolis inhibitory concentration (IC50) is determined as 61.78 µg mL−1. When loaded into fibers, propolis is gradually delivered to cells as Balb/3T3 fibroblasts and are able to adhere, grow, and interact with pristine and propolis‐loaded fibers, and cytotoxicity is not observed. Therefore, the zein–propolis nanofibers are considered biocompatible and safe. The results are promising and provide prospects for the development of wound‐healing nanofiber patches—one of propolis' main applications.

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“…In mice, an ethanol extract of propolis showed antihyperlipidemic and antioxidant activity and exhibited protective action on the cardiovascular system and hepatorenal functions [247]. Anvarifard et al [248] recently reviewed the cellular mechanisms of Propolis on preserving renal functions. Antidiabetic effects of propolis extracts and their isolated bioactive compounds are shown in Table 9.…”

Section: Antidiabetic Effectsmentioning

confidence: 99%

Propolis: An update on its chemistry and pharmacological applications

et al. 2022

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Propolis, a resinous substance produced by honeybees from various plant sources, has been used for thousands of years in traditional medicine for several purposes all over the world. The precise composition of propolis varies according to plant source, seasons harvesting, geography, type of bee flora, climate changes, and honeybee species at the site of collection. This apiary product has broad clinical applications such as antioxidant, anti-inflammatory, antimicrobial, anticancer, analgesic, antidepressant, and anxiolytic as well asimmunomodulatory effects. It is also well known from traditional uses in treating purulent disorders, improving the wound healing, and alleviating many of the related discomforts. Even if its use was already widespread since ancient times, after the First and Second World War, it has grown even more as well as the studies to identify its chemical and pharmacological features, allowing to discriminate the qualities of propolis in terms of the chemical profile and relative biological activity based on the geographic place of origin. Recently, several in vitro and in vivo studies have been carried out and new insights into the pharmaceutical prospects of this bee product in the management of different disorders, have been highlighted. Specifically, the available literature confirms the efficacy of propolis and its bioactive compounds in the reduction of cancer progression, inhibition of bacterial and viral infections as well as mitigation of parasitic-related symptoms, paving the way to the use of propolis as an alternative approach to improve the human health. However, a more conscious use of propolis in terms of standardized extracts as well as new clinical studies are needed to substantiate these health claims.

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A comprehensive insight into the molecular and cellular mechanisms of the effects of Propolis on preserving renal function: a systematic review

Cited by 13 publications

References 107 publications

Cerium–Luteolin Nanocomplexes in Managing Inflammation-Related Diseases by Antioxidant and Immunoregulation

Cerium–Luteolin Nanocomplexes in Managing Inflammation-Related Diseases by Antioxidant and Immunoregulation

Preparation and Investigation of Thermally Annealed Zein–Propolis Electrospun Nanofibers for Biomedical Applications

Propolis: An update on its chemistry and pharmacological applications

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