Objectives: This study was conducted to interpret the micro and macro environmental issues of public hospitals in order to equip hospital managers to plan and perform proactively and could deal more better with uncertain future.Results: semi-structured in-depth interview and a researcher-made questionnaire were used to determine macro and micro level issues based on PESTLE (Political, Economic, Social, Technological, Legal and Environmental) and Douglas West framework in order to determine the effectiveness and feasibility of factors The key issues at micro level environment were related to prescription and overuse of pharmaceuticals, inequality in distribution of healthcare services and high demands for luxurious services. At macro level: changes in disease patterns, inappropriate hospital budgeting, economic sanctions, government corruption and centralization had a great impact on public hospitals in Iran. following the safety guidelines laid down by the government and better management of bed distribution in order to decrease waiting times at micro level and improve strategic policies in order to have quality-based payment system, enhance the efficiency and effectiveness of services and strategic purchasing are the most important ways at macro level. At this time, the considerable impact of economic sanctions on hospital financial resources should not be ignored. PESTLE: Political, Economic, Social, Technological, Legal and Environmental Douglas West et al. framework: examines key aspects of marketing strategies such as customer, public, media, distributors, suppliers, stakeholders, and competitors combined with the presentation of a synthesis of recent thinking on the subject. MAXQDA: Is a software program designed for computer-assisted qualitative and mixed methods data, text and multimedia analysis in academic, scientific, and business institutions HTA: Health Technology Assessments Declarations