A comprehensive meta-analysis and prioritization study to identify vitiligo associated coding and non-coding SNV candidates using web-based bioinformatics tools

Dutta, Tithi; Mitra, Sayantan; Saha, Arpan; Ganguly, Kausik; Pyne, Tushar; Sengupta, Mainak

doi:10.1038/s41598-022-18766-9

Cited by 10 publications

(4 citation statements)

References 51 publications

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“…MTHFR polymorphisms are associated with AA [127], psoriasis [128], and vitiligo [129]. Elevated Hcy is also associated with psoriasis [130] and vitiligo [131,132]. The vital role of magnesium and B vitamin sufficiency in minimizing the deleterious effects of MTHFR polymorphisms is seen in figure 5.…”

Section: Magnesium and B Vitaminsmentioning

confidence: 99%

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

W. Chambers

2024

JNNS

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The dermatological manifestations of Long Covid (LC) have languished in the shadows of chronic fatigue and brain fog. Yet they are all linked by gut dysbiosis and the cytokine triad of TNF-α, IL-1β, and IL-6. The gut microbiome common not only to LC, psoriasis, AA, and vitiligo but also to neurodegenerative disease has been recently described. This gut microbiome induces an altered tryptophan metabolism linked to autoimmune disease. SARS CoV2, Mycobacteria, and many intestinal parasites protectively upregulate IFN-γ (less Covid in BCG and in subSaharan Africa), triggering the characteristic altered tryptophan metabolism and curtailing synthesis of serotonin and melatonin. Chronic inflammation due to persistent spike protein S exhausts IFN-γ and leads to gut dysbiosis and autoimmune risk. Butyrate immunomodulates IFN-γ and TGF-β, which counterbalance each other (reciprocal relationship). Low IFN-γ (LC) translates to high TGF-β (organ fibrosis). This review suggests that an etiologic prebiotic (d-mannose)/probiotic (lactobacilli, bifidobacteria)/postbiotic (butyrate) approach to autoimmune skin disease that improves intestinal barrier integrity and that suppresses the triad of TNF-α, IL-6, and IL-1β may enhance or even eliminate the traditional immunotherapy of targeted monoclonal antibodies, Janus kinase inhibitors, and steroids. Health benefits of this approach extend well beyond suppression of autoimmune skin disease. Societal benefits include relief to those most affected - women (LC), especially of color (AA, psoriasis, vitiligo).

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Section: Magnesium and B Vitaminsmentioning

confidence: 99%

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

W. Chambers

2024

JNNS

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“…MTHFR polymorphisms are associated with AA 122 , psoriasis 123 , and vitiligo 124 . Elevated Hcy is also associated with psoriasis 125 and vitiligo 126,127 . The vital role of magnesium and B vitamin sufficiency in minimizing the deleterious effects of MTHFR polymorphisms is seen in figure 4.…”

Section: Magnesium and B Vitaminsmentioning

confidence: 99%

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

Chambers,

Chambers

2023

Preprint

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The dermatological manifestations of Long Covid (LC) have languished in the shadows of chronic fatigue and brain fog. Yet they are all linked by gut dysbiosis and the cytokine triad of TNF-α, IL-1β, and IL-6. The gut microbiome common not only to LC, psoriasis, AA, and vitiligo but also to neurodegenerative disease has been recently described. This gut microbiome induces an altered tryptophan metabolism linked to autoimmune disease. SARS CoV2 invades enterochromaffin cells rich in ACE2 receptors and curtails absorption of the essential amino acid tryptophan and subsequent synthesis of serotonin and melatonin. This review suggests that an etiologic prebiotic (d-mannose)/probiotic (lactobacilli, bifidobacteria)/postbiotic (butyrate) approach to autoimmune skin disease that improves intestinal barrier integrity and that suppresses the triad of TNF-α, IL-6, and IL-1β may enhance or even eliminate the traditional immunotherapy of targeted monoclonal antibodies, Janus kinase inhibitors, and steroids. Health benefits of this approach extend well beyond suppression of autoimmune skin disease.

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“…This frequency was somewhat in between the Hungarian and the English populations (Hungarian 43% in vitiligo patients and 36% in controls [17] , English 72.3% in vitiligo patients and 75.1% in controls [27] ), but the lack of difference in genotype frequency between the vitiligo patients and the controls was consistent among the three studies. Notably, a recent comprehensive meta-analysis and prioritization study to identify vitiligo associated coding and non-coding single-nucleotide variants (SNV) using web-based bioinformatics tools prioritized CAT gene, among 13 SNVs, from a set of 291 SNVs, as a candidate contributing to vitiligo pathogenesis [46] .…”

Section: Genotypementioning

confidence: 99%

A Cross-sectional Study of the Catalase Genetic Polymorphism (-262 cytosine/ thymine) and Blood Catalase Activity among Jordanian Vitiligo Patients

Alhawamdeh,

Bulatova,

Yousef

et al. 2023

Jordan j. pharm. sci.

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Vitiligo is brought on by functional melanocyte loss and manifests as white maculae that may cover the whole body's skin. There is a genetic background in the pathogenesis of vitiligo. Polymorphisms in different parts of catalase gene may affect the disease activity and result in less functional catalase, thus, accumulation of hydrogen peroxide, one of the oxidative factors that damage melanocytes. We evaluated the CAT 262 genetic polymorphism of vitiligo patients using the polymerase chain reaction (PCR) technique with at least one C and at least one T model. The study included 48 vitiligo patient and 51 control individuals. Family history of vitiligo was present in 27.1% of patients and autoimmune disease were diagnosed in 16.7% of patients. Three quarters of vitiligo patients (75.0%) reported that emotional stress was the major triggering factor for their disease. The CC genotype was predominant (56.2% in vitiligo patients and 62.7% in control) with no significant difference between the study groups (p=0.7). Catalase activity in blood was comparable between the study arms (159.1±21.6 MU/L in vitiligo patients and 151.3±25.4 MU/L in controls (p=0.15). We conclude that neither genetic polymorphism in CAT 262 C/T nor blood catalase activity is associated with vitiligo.

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A comprehensive meta-analysis and prioritization study to identify vitiligo associated coding and non-coding SNV candidates using web-based bioinformatics tools

Cited by 10 publications

References 51 publications

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic Approach

A Cross-sectional Study of the Catalase Genetic Polymorphism (-262 cytosine/ thymine) and Blood Catalase Activity among Jordanian Vitiligo Patients

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