A comprehensive overview of the neuropsychiatry of Parkinson's disease: A review

Khan, Muhammad Adnan; Quadri, Syed A.; Tohid, Hassaan

doi:10.1521/bumc.2017.81.1.53

Cited by 18 publications

(22 citation statements)

References 207 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, our results are consistent with other studies supporting a higher prevalence of mood disorders in this population ( 27 , 28 ). Some studies suggest that approximately 30–40% of PD patients undergo depression, evidencing a strong association between both disorders ( 29 ). Mood disorders are, in fact, one of the most characteristic non-motor manifestations of PD and they could be experienced at stage of the disease ( 30 , 31 ).…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Treatment-Seeking Behavioral Addiction Patients with and without Parkinson’s Disease

et al. 2017

View full text Add to dashboard Cite

The administration of dopaminergic medication to treat the symptoms of Parkinson’s disease (PD) is associated with addictive behaviors and impulse control disorders. Little is known, however, on how PD patients differ from other patients seeking treatments for behavioral addictions. The aim of this study was to compare the characteristics of behavioral addiction patients with and without PD. N = 2,460 treatment-seeking men diagnosed with a behavioral addiction were recruited from a university hospital. Sociodemographic, impulsivity [Barratt Impulsiveness Scale (BIS-11)], and personality [Temperament and Character Inventory-Revised (TCI-R)] measures were taken upon admission to outpatient treatment. Patients in the PD group were older and had a higher prevalence of mood disorders than patients without PD. In terms of personality characteristics and impulsivity traits, PD patients appeared to present a more functional profile than PD-free patients with a behavioral addiction. Our results suggest that PD patients with a behavioral addiction could be more difficult to detect than their PD-free counterparts in behavioral addiction clinical setting due to their reduced levels of impulsivity and more standard personality traits. As a whole, this suggests that PD patients with a behavioral addiction may have different needs from PD-free behavioral addiction patients and that they could potentially benefit from targeted interventions.

show abstract

Section: Discussionmentioning

confidence: 99%

A Comparison of Treatment-Seeking Behavioral Addiction Patients with and without Parkinson’s Disease

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Depression is one of the most common nonmotor symptoms of PD ( 1 ), which may present as the initial symptom, and can accelerate the progression of motor disablement and the decrease in quality of life in PD patients ( 2 , 3 ). However, given the lack of sufficient attention to the presence and severity of depression in Parkinson's disease (d-PD), most d-PD patients do not receive timely and appropriate treatment and are faced with the risks of decreased motor function and quality of life ( 3 ). It is therefore essential to reveal the pathophysiological mechanism of d-PD for the early diagnosis and precise treatment.…”

Section: Introductionmentioning

confidence: 99%

Structural Brain Network Alteration and its Correlation With Structural Impairments in Patients With Depression in de novo and Drug-Naïve Parkinson's Disease

Gou

Zhang

et al. 2018

Front. Neurol.

View full text Add to dashboard Cite

Purpose: Depression is common in Parkinson's disease (PD) and is correlated with the severity of motor deficits and quality of life. The present study aimed to investigate alterations in the structural brain network related to depression in Parkinson's disease (d-PD) and their correlations with structural impairments of white matter (WM).Materials and Methods: Data were acquired from the Parkinson Progression Markers Initiative (PPMI) database. A total of 84 de novo and drug-naïve PD patients were screened and classified into two groups according to the 15-item Geriatric Depression Scale (GDS-15): d-PD (n = 28) and nondepression in PD (nd-PD, n = 56). Additionally, 37 healthy controls (HC) were screened. All subjects underwent DTI and 3D-T1WI on a 3.0 T MR scanner. Individual structural brain networks were constructed and analyses were performed using graph theory and network-based statistics (NBS) at both global and local levels. Differences in global topological properties were explored among the three groups. The association models between node and edge changes and the GDS-15 were constructed to detect regions that were specifically correlated with d-PD. Tract-based spatial statistics (TBSS) was used to detect structural impairments of WM between the d-PD and nd-PD groups. The correlations between altered global topological properties and structural impairments were analyzed in the d-PD group.Results: The global efficiency and characteristic path length of the structural brain network were impaired in the d-PD group compared with those in the nd-PD and HC groups. Thirteen nodes and 1 subnetwork with 10 nodes and 12 edges specifically correlated with d-PD were detected. The left hippocampus, left parahippocampal, left lingual, left middle occipital, left inferior occipital, left fusiform, left middle temporal, and left inferior temporal regions were all involved in the results of node and edge analysis. No WM microstructural impairments were identified in the d-PD group.Conclusion: Our study suggests that the integration of the structural brain network is impaired with disrupted connectivity of limbic system and visual system in the de novo and drug-naïve d-PD patients.The topological properties assessing integration of the structural brain network can serve as a potential objective neuroimaging marker for early diagnosis of d-PD.

show abstract

“…It has been well recognized that patients with PD are often inflicted by depression or psychological commodities [ 34 – 36 ] because tremor, rigidity, bradykinesia, and/or postural instability impair daily activities as well as emotional state [ 37 , 38 ]. Deficits in hand dexterity may limit or restrict the individual's capacity to complete basic life tasks, such as writing [ 39 ], personal hygiene [ 40 ], eating with chopsticks, and dressing.…”

Section: Discussionmentioning

confidence: 99%

Wuqinxi Exercise Improves Hand Dexterity in Patients with Parkinson’s Disease

Wang

Xiao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. This study was designed to evaluate the effect of Wuqinxi after one session and 12-week intervention on hand dexterity in patients with Parkinson’s disease (PD). Methods. Forty-six elderly participants with mild-to-moderate PD were randomly assigned to the groups trained with Wuqinxi (n = 23) or stretching (n = 23). All participants practiced 60 min session of either of these exercises, 2 sessions a week for 12 weeks in standing position. The score of Purdue Pegboard Test (PPT) and time for Soda Pop Test (SPT) were performed to assess hand dexterity and motor function along assessing the 39 items of Parkinson’s Disease Questionnaire before and after 12-week interventions. In addition, the PPT scores were compared before vs. after one session of either of these two exercise modes. Results. Single session with either Wuqinxi or stretching exercise tended to improve PPT scores in PD patients. Furthermore, the improved SPT time was significant ( P < 0.01 ) following 12-week training interventions with Wuqinxi (−1.32 ± 0.38 sec) or stretching (−0.89 ± 0.16 sec), which showed no group difference ( P = 0.734 ). However, only the participants in Wuqinxi group significantly improved the PPT scores of the dominant hand (+0.61 ± 1.34), both hand (+1.83 ± 3.13) and assemble (+2.04 ± 3.44) performance after 12-week training intervention. In parallel with improved hand dexterity and motor function, 12-week Wuqinxi training also significantly improved the patient’s emotional wellbeing. Conclusion. The Wuqinxi intervention could be safely and effectively applied to improve hand dexterity following single-session exercise or 12-week training, which were accompanied by improved quality of life in patients with mild-to-moderate PD.

show abstract

A comprehensive overview of the neuropsychiatry of Parkinson's disease: A review

Cited by 18 publications

References 207 publications

A Comparison of Treatment-Seeking Behavioral Addiction Patients with and without Parkinson’s Disease

A Comparison of Treatment-Seeking Behavioral Addiction Patients with and without Parkinson’s Disease

Structural Brain Network Alteration and its Correlation With Structural Impairments in Patients With Depression in de novo and Drug-Naïve Parkinson's Disease

Wuqinxi Exercise Improves Hand Dexterity in Patients with Parkinson’s Disease

Contact Info

Product

Resources

About