A comprehensive review: Different approaches for encountering of bacterial infection of dental implants and improving their properties

Heydariyan, Zahra; Soofivand, Faezeh; Dawi, Elmuez A.; Al-Kahdum, Saafa Abaas Abd; Hameed, Noora M.; Salavati‐Niasari, Masoud

doi:10.1016/j.jddst.2023.104401

Cited by 4 publications

(2 citation statements)

References 92 publications

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“…Implant-related infections, as the main complication in implants, have always been one of the most challenging issues in clinical treatment [ 1 , 2 ]. According to reports, implant-related infections account for 60% of bacterial infections [ 3 ]. Excessive bacterial infection inevitably increases the healing time, causes incomplete repair of the damaged area, and even leads to the failure of implantable therapy, posing a serious threat to the patient’s life [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

A Photochemically Active Cu2O Nanoparticle Endows Scaffolds with Good Antibacterial Performance by Efficiently Generating Reactive Oxygen Species

He,

Zan,

et al. 2024

Nanomaterials

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Cuprous oxide (Cu2O) has great potential in photodynamic therapy for implant-associated infections due to its good biocompatibility and photoelectric properties. Nevertheless, the rapid recombination of electrons and holes weakens its photodynamic antibacterial effect. In this work, a new nanosystem (Cu2O@rGO) with excellent photodynamic performance was designed via the in situ growth of Cu2O on reduced graphene oxide (rGO). Specifically, rGO with lower Fermi levels served as an electron trap to capture photoexcited electrons from Cu2O, thereby promoting electron-hole separation. More importantly, the surface of rGO could quickly transfer electrons from Cu2O owing to its excellent conductivity, thus efficiently suppressing the recombination of electron-hole pairs. Subsequently, the Cu2O@rGO nanoparticle was introduced into poly-L-lactic acid (PLLA) powder to prepare PLLA/Cu2O@rGO porous scaffolds through selective laser sintering. Photochemical analysis showed that the photocurrent of Cu2O@rGO increased by about two times after the incorporation of GO nanosheets, thus enhancing the efficiency of photogenerated charge carriers and promoting electron-hole separation. Moreover, the ROS production of the PLLA/Cu2O@rGO scaffold was significantly increased by about two times as compared with that of the PLLA/Cu2O scaffold. The antibacterial results showed that PLLA/Cu2O@rGO possessed antibacterial rates of 83.7% and 81.3% against Escherichia coli and Staphylococcus aureus, respectively. In summary, this work provides an effective strategy for combating implant-related infections.

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Section: Introductionmentioning

confidence: 99%

A Photochemically Active Cu2O Nanoparticle Endows Scaffolds with Good Antibacterial Performance by Efficiently Generating Reactive Oxygen Species

He,

Zan,

et al. 2024

Nanomaterials

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“…There have been progressive implant failures associated with periimplant illnesses (peri-mucositis and peri-implantitis) [14]. Because systemic dosages may not be effective in overcoming the constraints of traditional therapy, the local injection of medications to the bone is also acknowledged as a possible alternative [15]. Therefore, surface modification for titanium is frequently necessary to enhance its bio-performance as an implant [11,12,[16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Silk Fibroin/ZnO Coated TiO2 Nanotubes for Improved Antimicrobial Effect of Ti Dental Implants

Păun,

Dumitriu,

Ungureanu

et al. 2023

Materials

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The aim of the present research is to develop a novel hybrid coating for a Ti dental implant that combines nature-inspired biomimetic polymers and TiO2 nanostructures with an entrapped ZnO antimicrobial agent. ZnO was used in other studies to cover the surface of Ti or Ti–Zr to reduce the need of clinical antibiotics, prevent the onset of peri-implantitis, and increase the success rate of oral clinical implantation. We developed an original coating that represents a promising approach in clinical dentistry. The titanium surface was first anodized to obtain TiO2 nanotubes (NT). Subsequently, on the NT surface, silk fibroin isolated from Bombyx mori cocoons was deposited as nanofibers using the electrospun technique. For an improved antibacterial effect, ZnO nanoparticles were incorporated in this biopolymer using three different methods. The surface properties of the newly created coatings were assessed to establish how they are influenced by the most important features: morphology, wettability, topography. The evaluation of stability by electrochemical methods in simulated physiological solutions was discussed more in detail, considering that it could bring necessary information related to the behavior of the implant material. All samples had improved roughness and hydrophilicity, as well as corrosion stability (with protection efficiency over 80%). The antibacterial test shows that the functional hybrid coating has good antibacterial activity because it can inhibit the proliferation of Staphylococcus aureus up to 53% and Enterococcus faecalis up to 55%. All Ti samples with the modified surface have proven superior properties compared with unmodified TiNT, which proved that they have the potential to be used as implant material in dentistry.

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Synergistic catecholamine and coordination chemistry for enhanced bioactivity and secondary grafting activity of zirconia dental implants

Gao,

Zhang,

Sun

et al. 2025

Colloids and Surfaces B: Biointerfaces

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A comprehensive review: Different approaches for encountering of bacterial infection of dental implants and improving their properties

Cited by 4 publications

References 92 publications

A Photochemically Active Cu2O Nanoparticle Endows Scaffolds with Good Antibacterial Performance by Efficiently Generating Reactive Oxygen Species

A Photochemically Active Cu2O Nanoparticle Endows Scaffolds with Good Antibacterial Performance by Efficiently Generating Reactive Oxygen Species

Silk Fibroin/ZnO Coated TiO2 Nanotubes for Improved Antimicrobial Effect of Ti Dental Implants

Synergistic catecholamine and coordination chemistry for enhanced bioactivity and secondary grafting activity of zirconia dental implants

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