2020
DOI: 10.1142/s0192415x20500020
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A Comprehensive Review for Phytochemical, Pharmacological, and Biosynthesis Studies onGlycyrrhizaspp.

Abstract: Licorice is extensively applied in food as well as herbal medicine across the world, possessing a substantial share in the global market. It has made great progress in chemical and pharmacological research in recent years. Currently, Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat., and Glycyrrhiza glabra L. were officially used as Gan-Cao according to the Chinese Pharmacopoeia. Accumulating evidence demonstrated three varieties of licorice have their own special compounds except for two quality markers … Show more

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Cited by 92 publications
(52 citation statements)
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“…Licorice extracts have antiviral, antimicrobial, antioxidant, anti-inflammatory and antitumor characteristics [ 108 , 109 ], determined by triterpene saponins and flavonoids. The main triterpene saponin is glycyrrhizin (5–10% of roots), from phenolic compounds liquirytigenin, isolivytigenin and their glycosidic derivatives (around 1% of licorice water extract) [ 110 , 111 , 112 ].…”
Section: Resultsmentioning
confidence: 99%
“…Licorice extracts have antiviral, antimicrobial, antioxidant, anti-inflammatory and antitumor characteristics [ 108 , 109 ], determined by triterpene saponins and flavonoids. The main triterpene saponin is glycyrrhizin (5–10% of roots), from phenolic compounds liquirytigenin, isolivytigenin and their glycosidic derivatives (around 1% of licorice water extract) [ 110 , 111 , 112 ].…”
Section: Resultsmentioning
confidence: 99%
“…It is one of the oldest known medicinal herbs and is referred to as “the father of herbal medicine.” Glycyrrhizic acid (GA) ( Figure 1A ), a triterpenoid saponin, is a major component of licorice. It has a variety of pharmacological activities such as anti-inflammatory, antioxidant, anticancer, neuroprotective, and immune-regulatory effects, among others ( Wang et al, 2020 ). Previous studies indicated that GA produces robust neuroprotection via the modulation of anti-apoptotic and pro-apoptotic factors, primarily through the ERK signaling pathway and its anti-inflammatory properties against high-mobility group box 1 phosphorylation and the suppression of inflammatory cytokine induction ( Gong et al, 2012 ; Kim et al, 2012 ; Teng et al, 2014 ).…”
Section: Introductionmentioning
confidence: 99%
“…In recent decades, extensive research has been conducted regarding the bioactive constituents, biosynthesis, pharmacological mechanisms, and clinical applications, in glycyrrhiza, among other aspects [5,[10][11][12][13]. The major bioactive secondary metabolites of glycyrrhiza include triterpene saponins, various types of flavonoids, coumarins, polysaccharides, and other phenolics [10,14]. Unfortunately, no systematic review has been conducted as yet regarding the chemical structure, origin, and corresponding references of triterpenoid saponins.…”
Section: Introductionmentioning
confidence: 99%