A comprehensive review of 3D bioprinting biomaterials: Properties, strategies and wound healing application

Choudary, R. J.; Saini, Neha; Chopra, Dimple; Singh, Devinder; Singh, Nirmal

doi:10.1557/s43578-023-01078-7

Cited by 5 publications

(1 citation statement)

References 172 publications

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“…EBB has the advantage of being able to form complex structures, including internal architecture, without the need to prepare molds with cell-dense solutions as bioinks [14]. Conversely, problems with EBB include cellular damage due to pressure and shear forces during bioink ejection, the difficulty of developing bioinks with appropriate mechanical, structural, and biological properties, and the long time required to print full-size organs [15][16][17]. Volumetric Bioprinting (VBP), unlike conventional methods (i.e., layer-by-layer stacking), creates an object by photo-crosslinking the resin by exposing it to a calculated two-dimensional (2D) light pattern while rotating a transparent container [18].…”

Section: Introductionmentioning

confidence: 99%

Geometrically-engineered organoid units and their assembly for pre-construction of organ structures

Kadotani,

Hayase,

Yoshino

2024

Preprint

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Regenerative medicine is moving from the nascent to the transitional stage as researchers are actively engaged in creating mini-organs from pluripotent stem cells to construct artificial models of physiological and pathological conditions. Currently, mini-organs can express higher-order functions, but their size is limited to the order of a few millimeters. Therefore, one of the ultimate goals of regenerative medicine, " organ replication and transplantation with organoid," remains a major obstacle. 3D bioprinting technology is expected to be an innovative breakthrough in this field, but various issues have been raised, such as cell damage, versatility of bioink, and printing time. In this study, we established a method for fabricating, connecting, and assembling organoid units of various shapes independent of cell type, extracellular matrix, and adhesive composition (unit construction method). We also fabricated kidney tissue-like structures using three types of parenchymal and interstitial cells that compose the human kidney and obtained findings suggesting the possibility of crosstalk between the units. We anticipate that this technique will bring us closer to the realization of highly efficient and rapid fabrication of full-scale organoids that can withstand organ transplantation.

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Section: Introductionmentioning

confidence: 99%

Geometrically-engineered organoid units and their assembly for pre-construction of organ structures

Kadotani,

Hayase,

Yoshino

2024

Preprint

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Leveraging 3d Printing for Advanced Wound Dressing Technologies by Using Polymeric Materials and Polymeric Biomaterials

Jadhav,

Bhingoli,

Mali

et al. 2024

Hybrid Advances

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Integration of Hydrogels and 3D Bioprinting Technologies for Chronic Wound Healing Management

Kumi,

Chen,

Zhang

et al. 2024

ACS Biomater. Sci. Eng.

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The integration of hydrogel-based bioinks with 3D bioprinting technologies presents an innovative approach to chronic wound management, which is particularly challenging to treat because of its multifactorial nature and high risk of complications. Using precise deposition techniques, 3D bioprinting significantly alters traditional wound care paradigms by enabling the fabrication of patient-specific wound dressings that imitate natural tissue properties. Hydrogels are notably beneficial for these applications because of their abundant water content and mechanical properties, which promote cell viability and pathophysiological processes of wound healing, such as re-epithelialization and angiogenesis. This article reviews key 3D printing technologies and their significance in enhancing the structural and functional outcomes of wound-care solutions. Challenges in bioink viscosity, cell viability, and printability are addressed, along with discussions on the cross-linking and mechanical stability of the constructs. The potential of 3D bioprinting to revolutionize chronic wound management rests on its capacity to generate remedies that expedite healing and minimize infection risks. Nevertheless, further studies and clinical trials are necessary to advance these therapies from laboratory to clinical use.

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A comprehensive review of 3D bioprinting biomaterials: Properties, strategies and wound healing application

Cited by 5 publications

References 172 publications

Geometrically-engineered organoid units and their assembly for pre-construction of organ structures

Geometrically-engineered organoid units and their assembly for pre-construction of organ structures

Leveraging 3d Printing for Advanced Wound Dressing Technologies by Using Polymeric Materials and Polymeric Biomaterials

Integration of Hydrogels and 3D Bioprinting Technologies for Chronic Wound Healing Management

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