A comprehensive review on 2-substituted benzimidazole derivatives and its biological importance

Abstract

Condensation of o-phenylene-diamine with formic acid is used in the synthesis of commercially available benzimidazole. N-ribosyldimethyl benzimidazole is the most common benzimidazole compound found in nature, and it functions as an axial ligand for cobalt in vitamin B12. The benzimidazole and its derivatives are important therapeutic agents, such as antiulcer and anthelmintic drugs. Benzimidazole compounds also possess antimicrobial, antiviral, anticancer, anti-inflammatory, analgesic, and other pharmacological properties. The chemistry and pharmacological actions of substituted benzimidazoles are summarised in this article.