A Comprehensive Review on Applicability and Bioactivity of Rogan-I-Kunjad (Sesamum indicum L-Oil): Unani Prospective

Abstract

Sesame oil has a long history of usage as a food and medicine. It is the most used oil as a medicine or as a base oil for preparations of many compound drugs in the Unani system of medicine. It has a wide range of biological activities as mentioned in Unani classical text; this review highlights its pharmacological activities and their possible mode of action. Searched many Unani classical literature online and offline and simultaneously did parallel search on databases like PubMed, and Science Direct, and extraction of data related to sesame oil, sesame seeds with its pharmacological activities, mode of action, then interpretation and summarization of all related data. Sesame oil possesses many biological activities like anti-inflammatory, antihyperlipidemic, antiatherosclerotic, hepatoprotective, antiasthmatic, analgesic, emollient, antipruritic, and wound healing effects, which were scientifically demonstrated as mentioned in Unani literature. Sesame oil has a hopeful effect on modulating diseases with no significant toxic effect; so, there is a need to identify its safety and efficacy on human subjects to develop a new potential drug.

Alleviating severity of limb trauma pain with coadministration of topical sesame oil and standard treatments: A GRADE‐assessed systematic review and meta‐analysis of randomised controlled trials

“… 40 SO is one of the well‐known herbal remedies traditionally used to treat various conditions, including musculoskeletal pain and stiffness, inflammation, bruising, wound, and injury. 18 , 22 , 41 Recent RCTs have investigated the potential impact of administrating SO on treating the pain of limb trauma; however, their findings are controversial. Accordingly, we synthesised these conflicting findings qualitatively and quantitatively to elicit a reliable conclusion regarding the potential effect of topical SO for alleviating limb trauma pain.…”

“… 15 , 16 Sesame oil (SO), extracted from the seeds of the sesame plant ( Sesamum indicum L ., Pedaliaceae family), is one of the well‐known herbal agents with analgesic and anti‐inflammatory properties utilised in traditional medicines to treat different wounds, injuries, and pains. 17 , 18 In Traditional Iranian Medicine (TIM), SO is suggested for healing musculoskeletal pain and inflammation. 19 , 20 Besides, in the Unani system of medicine, SO is a well‐known remedy for treating musculoskeletal stiffness and pain, pruritus, wounds, and headaches.…”

“…19 , 20 Besides, in the Unani system of medicine, SO is a well‐known remedy for treating musculoskeletal stiffness and pain, pruritus, wounds, and headaches. 18 Also, in traditional Taiwanese medicine, SO has been utilised to relieve joint pains, toothaches, scrapes, cuts, and muscle cramps. 21 Likewise, the medicinal properties of SO have been acknowledged and incorporated into the traditional medical systems of China and India, given its benefits for treating pain, inflammation, wound, and haemorrhoid.…”