A comprehensive review on human health effects of chromium: insights on induced toxicity

Hossini, Hooshyar; Shafie, Behnaz; Niri, Amir Dehghan; Nazari, Mahboubeh; Esfahlan, Aylin Jahanban; Ahmadpour, Mohammad; Nazmara, Zohreh; Ahmadimanesh, Mahnaz; Makhdoumi, Pouran; Mirzaei, Nezam; Hoseinzadeh, Edris

doi:10.1007/s11356-022-22705-6

Cited by 161 publications

(39 citation statements)

References 150 publications

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“…Numerous studies have confirmed that higher concentrations of Cr can inhibit plant growth by reducing photosynthesis, disrupting mineral nutrient uptake, and disturbing metabolic homeostasis [ 5 , 6 ]. Cr(VI) can enter the human body through dietary ingestion and environmental exposure, causing various diseases such as lung cancer and gastric cancer [ 7 ]. In China, 1.26% of arable land is facing a high risk of Cr pollution.…”

Section: Introductionmentioning

confidence: 99%

Melatonin Alleviates Chromium Toxicity in Maize by Modulation of Cell Wall Polysaccharides Biosynthesis, Glutathione Metabolism, and Antioxidant Capacity

Yang

Ren

Lin

et al. 2023

IJMS

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Melatonin, a pleiotropic regulatory molecule, is involved in the defense against heavy metal stress. Here, we used a combined transcriptomic and physiological approach to investigate the underlying mechanism of melatonin in mitigating chromium (Cr) toxicity in Zea mays L. Maize plants were treated with either melatonin (10, 25, 50 and 100 μM) or water and exposed to 100 μM K2Cr2O7 for seven days. We showed that melatonin treatment significantly decreased the Cr content in leaves. However, the Cr content in the roots was not affected by melatonin. Analyses of RNA sequencing, enzyme activities, and metabolite contents showed that melatonin affected cell wall polysaccharide biosynthesis, glutathione (GSH) metabolism, and redox homeostasis. During Cr stress, melatonin treatment increased cell wall polysaccharide contents, thereby retaining more Cr in the cell wall. Meanwhile, melatonin improved the GSH and phytochelatin contents to chelate Cr, and the chelated complexes were then transported to the vacuoles for sequestration. Furthermore, melatonin mitigated Cr-induced oxidative stress by enhancing the capacity of enzymatic and non-enzymatic antioxidants. Moreover, melatonin biosynthesis-defective mutants exhibited decreased Cr stress resistance, which was related to lower pectin, hemicellulose 1, and hemicellulose 2 than wild-type plants. These results suggest that melatonin alleviates Cr toxicity in maize by promoting Cr sequestration, re-establishing redox homeostasis, and inhibiting Cr transport from the root to the shoot.

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Section: Introductionmentioning

confidence: 99%

Melatonin Alleviates Chromium Toxicity in Maize by Modulation of Cell Wall Polysaccharides Biosynthesis, Glutathione Metabolism, and Antioxidant Capacity

Yang

Ren

Lin

et al. 2023

IJMS

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“…However, there is no convincing evidence that can confidently conclude the essential role of Cr in human beings ( 102 ). Conversely, Cr exposure has been associated with multiple health hazards such as allergy, impaired reproductive system, and cancer ( 103 ). Cr exposure during pregnancy has been associated with poor fetal biometric parameters such as abdominal circumference and estimated fetal weight, suggesting the embryonic toxicity of Cr ( 104 ).…”

Section: Non-essential Trace Elements and Congenital Heart Diseasesmentioning

confidence: 99%

Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review

et al. 2023

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Congenital heart defects (CHDs) are congenital abnormalities involving the gross structures of the heart and large blood vessels. Environmental factors, genetic factors and their interactions may contribute to the pathogenesis of CHDs. Generally, trace elements can be classified into essential trace elements and non-essential trace elements. Essential trace elements such as copper (Cu), zinc (Zn), iron (Fe), selenium (Se), and manganese (Mn) play important roles in human biological functions such as metabolic function, oxidative stress regulation, and embryonic development. Non-essential trace elements such as cadmium (Cd), arsenic (As), lead (Pb), nickle (Ni), barium (Ba), chromium (Cr) and mercury (Hg) are harmful to health even at low concentrations. Recent studies have revealed the potential involvement of these trace elements in the pathogenesis of CHDs. In this review, we summarized current studies exploring exposure to essential and non-essential trace elements and risks of CHDs, in order to provide further insights for the pathogenesis and prevention of CHDs.

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“…Chromium VI contamination in the atmosphere has toxicological effects on the respiratory, mutagenic, genotoxic, cardiovascular, and reproductive systems of humans, [21,22]. The lower concentrations (Conc.)…”

Section: On Human and Faunal Impactmentioning

confidence: 99%

The Strategies of Chromite Terrace in Sukinda Valley, India: An Appraisal

Mishra

Samal²,

Sohel³

et al. 2022

JSRR

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Iron chrome oxide (FeCr 2O4), is a commercially viable and major ingredient of stainless steel. The Odisha state in India possesses 98% of the pre-Cambrian India’s Chromite ore deposits in Sukinda valley, Jajpur District. To meet the present escalating demand for chromium in steel industries, it is urged to extract more chrome ore to satiate domestic needs. The depletion of chrome deposits, rise in demand, fewer chrome mines, and less conversion from tailings increase of more toxic hexavalent chrome ion level in the geo-bio hydrosphere, shall aggravate health concerns for the people, fauna, and flora in Sukinda Ultramafic Complex (SUC). The present quest is a collection of chromite ores and tailings. A chemical study is done by using the X-ray fluorescent spectrometer. An insitu/GIS study of the Sukinda ultramafic complex by using Arc-GIS, and ERADAS software has been done to originate hydrology, aspect, and hill-shade map of the valley. The literature, and as an inhabitant of the area helped in preparing the strategic plan through Environmental Impact Assessment and Environmental Management Plan. CR (III) is a dietary requirement. The anthropogenic activities and atmospheric exposure have converted Cr (III) to Cr (VI) in SUC and have surpassed the recommended values. The noxious Cr (VI) in the geo-bio-hydrosphere shall invite health and environmental concerns in the future. The aboriginals of SUC are economically burdened with food insecurity, poor livelihood, health, and of formal societal values. The Sukinda Valley ore samples contain 50% chromite ore is economic. But the >7% of CR (III) ore in the tailings and overburden shall warrant the future expected exorbitant Cr (VI) in the geo-bio-hydro environment of Sukinda valley.

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A comprehensive review on human health effects of chromium: insights on induced toxicity

Cited by 161 publications

References 150 publications

Melatonin Alleviates Chromium Toxicity in Maize by Modulation of Cell Wall Polysaccharides Biosynthesis, Glutathione Metabolism, and Antioxidant Capacity

Melatonin Alleviates Chromium Toxicity in Maize by Modulation of Cell Wall Polysaccharides Biosynthesis, Glutathione Metabolism, and Antioxidant Capacity

Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review

The Strategies of Chromite Terrace in Sukinda Valley, India: An Appraisal

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