In this paper, a 3 dB 90-degree hybrid coupler with size reduction and harmonics rejection was designed. In the proposed coupler structure, four simple low-pass filters (LPFs) were applied. An artificial neural network (ANN) was used to determine the dimensions of the applied LPFs based on EM simulation data. The applied ANN model could also provide the desired LPF parameters, including the cut-off frequency (fc), bandwidth (BW), and insertion loss (IL). Designing an applied LPF involves complex mathematical calculations and simulations to optimize parameters. However, by utilizing neural networks, the design process can be significantly streamlined and automated. Neural networks have the ability to learn complex patterns and relationships within data, making them well suited for optimizing the performance of applied components. The proposed 90-degree hybrid coupler works correctly at 1800 MHz and has a small size of 16.6 mm × 15.15 mm, which provides a 73% size reduction compared to a normal 1800 MHz coupler. The designed coupler not only decreases the circuit size but also provides a wide rejection band from 4.8 GHz to 11.2 GHz, which suppresses the second to sixth harmonics. The insertion loss parameter of this 90-degree hybrid coupler is less than 0.1 dB at the working frequency, which shows the superior performance of the proposed coupler.