A comprehensive review on plasmonic-based biosensors used in viral diagnostics

Shrivastav, Anand M.; Cvelbar, Uroš; Abdulhalim, Ibrahim

doi:10.1038/s42003-020-01615-8

Cited by 352 publications

(238 citation statements)

References 115 publications

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“…On the other side, figure of merit (FOM) parameter is used to indicate the selectivity of the sensor. FOM is defined as the ratio between sensitivity and full width at half maximum (FWHM) [24,37,46]. Thus, the higher the FOM is, the more selective the sensor is.…”

Section: Simulation Results and Discussionmentioning

confidence: 99%

Ultra-high-sensitive sensor based on a metal–insulator–metal waveguide coupled with cross cavity

2021

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In this paper, a high-sensitive plasmonic sensor based on metal-insulator-metal waveguide coupled with the interesting metal nanoracetrack defects in a cross cavity is proposed and investigated. The sensing characteristics of the proposed design are analyzed by the means of finite difference time domain method which is embedded in the commercial simulator R-Soft. The positions of transmission peaks can be easily manipulated by adjusting both the radius and the distance between the centers of the two racetrack defects in the cavity. The achieved results exhibit a linear relationship between the material's refractive indices and theirs corresponding wavelengths of resonance, whereas the obtained maximum linear sensitivity is 3410 nm/RIU which corresponds to a sensing resolution as precise as 2.93 × 10 −6 RIU. The proposed sensor has great impact on different technologies advancement as it can be implemented in high performance nanosensors and bio-sensing devices.

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Section: Simulation Results and Discussionmentioning

confidence: 99%

Ultra-high-sensitive sensor based on a metal–insulator–metal waveguide coupled with cross cavity

2021

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“…SERS reaches signal enhancement 10 6-10 9 times, yielding exceptional sensitivity. 94 Influenza virus identification,…”

Section: Materials Advances Accepted Manuscriptmentioning

confidence: 99%

Magnetic nanoparticles: an emerging nano-based tool to fight against viral infections

et al. 2021

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“…urine, saliva, and tears) on a substrate, then, the target material (biomarker) in the body fluid reacts with a reactant (bioreceptor) fixed on the sensor, and the presence or absence of disease is determined by the specific signal change that appears. The quantification of biological and biochemical processes is very important for medical and biological applications [5]. Biosensors that use electrochemistry are extremely useful due to the fact that they convert biological samples into an electrical signal that can easily process information.…”

Section: Introductionmentioning

confidence: 99%

Technological advances in electrochemical biosensors for the detection of disease biomarkers

et al. 2021

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With an increasing focus on health in contemporary society, interest in the diagnosis, treatment, and prevention of diseases has grown rapidly. Accordingly, the demand for biosensors for the early diagnosis of disease is increasing. However, the measurement range of existing electrochemical sensors is relatively high, which is not suitable for early disease diagnosis, requiring the detection of small amounts of biocomponents. Various attempts have been made to overcome this and amplify the signal, including binding with various labeling molecules, such as DNA, enzymes, nanoparticles, and carbon materials. Efforts are also being made to increase the sensitivity of electrochemical sensors, and the combination of nanomaterials, materials, and biotechnology offers the potential to increase sensitivity in a variety of ways. Recent studies suggest that electrochemical sensors can be a powerful tool in providing comprehensive insights into the targeting and detection of disease-associated biomarkers. Significant advances in nanomaterial and biomolecule approaches for improved sensitivity have resulted in the development of electrochemical biosensors capable of detecting multiple biomarkers in real time in clinically relevant samples. In this review, we have discussed the recent studies on electrochemical sensors for detection of diseases such as diabetes, degenerative diseases, and cancer. Further, we have highlighted new technologies to improve sensitivity using various materials, including DNA, enzymes, nanoparticles, and carbon materials.

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A comprehensive review on plasmonic-based biosensors used in viral diagnostics

Cited by 352 publications

References 115 publications

Ultra-high-sensitive sensor based on a metal–insulator–metal waveguide coupled with cross cavity

Ultra-high-sensitive sensor based on a metal–insulator–metal waveguide coupled with cross cavity

Magnetic nanoparticles: an emerging nano-based tool to fight against viral infections

Technological advances in electrochemical biosensors for the detection of disease biomarkers

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