A Comprehensive Review on Role of Nanoparticles in Therapeutic Delivery of Medicine

Abstract

The objective of this review is to cover the drug delivery system of various therapeutic drugs and biomolecules by means of polymeric nanoparticles, dendrimers, liposomal nanoparticles and magnetic nanoparticles by describing the methods of formulation development.

The therapeutic potential of sialylated Fc domains of human IgG

“…The lack of target specificity can lead to faster in vivo clearance rates and may also explain reported toxicities for many polymeric inhibitors. 95,96 This has driven the search for smaller, rationally designed sialylated scaffolds. Using a rigid self-assembled peptide nucleic acid complex, it has recently been shown that smaller bivalent displays of the natural sialyl-LacNAc ligand (50-68 Å between each sugar) are more effective at binding a single HA trimer and inhibiting hemagglutination by virus than longer scaffolds with sialic acid residues separated by distances >100 Å that may allow for inter-HA bridging, which may also be desirable.…”

Co-delivery of brinzolamide and miRNA-124 by biodegradable nanoparticles as a strategy for glaucoma therapy

“…Nano-sized drug carriers have been conducted in the field of ophthalmology (Kim et al, 2009;Lee et al, 2017;Liao et al, 2017;Rathor et al, 2017). There are at least five prevalent categories of nanoscale delivery systems including viral capsids, lipid-based nanoparticles, peptide-based nanoparticles, polymer-based nanoparticles, and silicon nanoparticles.…”

“…Moreover, the drugs encapsulated in nanoparticles are capable of penetrating deeply into the targeting regions while enabling the safe and efficacious medication compared to the standard formulations (Suk & Gopinath, 2017). In addition, the encapsulated drug delivery systems enable the nanoparticles to have suitable particle size, surface properties and ability to cross the vitreous body smoothly, ensuring the effectiveness of drugs (Rathor et al, 2017;Suk & Gopinath, 2017). High polymer graft copolymerization technology was used for polymerization of two polyanhydrides (Rathor et al, 2017).…”

“…In addition, the encapsulated drug delivery systems enable the nanoparticles to have suitable particle size, surface properties and ability to cross the vitreous body smoothly, ensuring the effectiveness of drugs (Rathor et al, 2017;Suk & Gopinath, 2017). High polymer graft copolymerization technology was used for polymerization of two polyanhydrides (Rathor et al, 2017). Based on the above points, we designed a nanoparticle (NP) drugloading system where drug molecules are encapsulated with the aid of carrier materials that can help overcome issues such as poor bioavailability, high drug dosage, and short drug half-life.…”

Chitosan and Liposomes Nanoparticles Encapsulated Cinnamon Extract: Antiproteolytic Activity and Wound Healing Efficiency of Diabetic Rats Running Head: Chitosan vs Liposomes Nanoparticles as Drug Delivery Carriers

“…On the other hand, liposomes have been the first to be investigated as drug carriers. They are nano/micro-particular or colloidal carriers, usually with 80-300 nm size range (Rathor et al, 2017). They are spherical vesicles composed of phospholipids and steroids (e.g., cholesterol), bilayers, or other surfactants and form spontaneously when certain lipids are dispersed in aqueous media where liposomes can be prepared, e.g., by sonication (Matougui et al, 2016).…”