A comprehensive review on synthesis, biological profile and photophysical studies of heterocyclic compounds derived from 2,3-diamino-1,4-naphthoquinone

Anti‐inflammatory Potential of 1,4‐Naphthoquinone Acyl Thiourea Hybrids on Lipopolysaccharide‐Activated Mammalian Macrophages, and Their Acid Dissociation Constants

“…It has been stated in previous studies that 1,4-naphthoquinone acyl thiourea hybrids can be used as drug candidates thanks to their molecular weight, hydrogen bond donor and acceptor numbers, as well as have antimicrobial, antiviral, antihypertensive, antidiabetic, anti-neurodegenerative properties. [1][2][3] Since naphthoquinone hybrids are naphthalene-derived, they transfer naphthalene to their hybrids without losing their cytotoxic effect. The FDA approval of most naphthalene-based, derivative, and hybrid drugs also increases the potential of these new hybrids to be used as drug candidates.…”

“…Naphthoquinone is one of the most studied pharmacophore groups in medicinal chemistry and it is known to be present in the molecular structure of many natural and synthetic bioactive compounds [1–3] . Compounds containing naphthoquinone moiety exhibit a wide range of pharmacological activities such as anti‐inflammatory, [4,5] antimicrobial, [6–8] antiviral, [9] antimalarial, [10] and anticancer [11,12] as well as DNA cleavage activity [13] .…”

“…Naphthoquinone is one of the most studied pharmacophore groups in medicinal chemistry and it is known to be present in the molecular structure of many natural and synthetic bioactive compounds. [1][2][3] Compounds containing naphthoquinone moiety exhibit a wide range of pharmacological activities such as anti-inflammatory, [4,5] antimicrobial, [6][7][8] antiviral, [9] antimalarial, [10] and anticancer [11,12] as well as DNA cleavage activity. [13] In recent years, studies have been conducted in which various naphthoquinone derivatives have been synthesized for the treatment of Alzheimer's, and their activities on enzymes associated with this disease have been investigated.…”

KuQuinones: a ten years tale of the new pentacyclic quinoid compound

“…Quinone peculiar features are not limited to their interesting reversible electrochemical behaviour. Indeed, their skeleton can be easily modified 4–7 with the aim to tune their electronic and electrochemical properties, so extending the range of potential applications. Anthraquinones, naphthoquinones and benzoquinones have been used as electroactive compounds in energy storage devices, 8 as redox flow batteries, 9,10 lithium ions batteries, 8 supercapacitors, 11 in water-splitting processes, in hydrogen production, and in n-type Dye Sensitized Solar Cells (n-DSSCs).…”

“…Anthraquinones, naphthoquinones and benzoquinones have been used as electroactive compounds in energy storage devices, 8 as redox flow batteries, 9,10 lithium ions batteries, 8 supercapacitors, 11 in water-splitting processes, in hydrogen production, and in n-type Dye Sensitized Solar Cells (n-DSSCs). 12 In addition, quinones possess a privileged scaffold for applications in medicinal chemistry; 7,13 indeed, both synthetic and natural derivatives can act as anticancer, 5,14,15 antibacterial, 16 antifungal, antiviral, 17 anti-Alzheimer and antimalarial 18 drugs. Moreover, they are characterized by interesting antioxidant activity, being also adopted in wound healing treatment.…”