A Comprehensive Review on the Benzimidazole Scaffold as a Potential Nucleus for Anticancer Activity

Abstract

It is common knowledge that cancer is the world's biggest cause of mortality. This has led to the ongoing introduction and validation of new cancer therapy outcomes. Benzimidazole derivatives control DNA stability and cell cycle advancement. A heterocyclic nucleus is structurally more favourable for a direct DNA connection and, thus, for the management of the DNA replication process. This review seeks to explore the usefulness of such drugs in the future facets of cancer prognosis and treatment in addition to discussing the role of benzimidazole in cancer therapy. Benzimidazole derivatives have been reported as a pertinent therapeutic strategy to modify cancer progression and malignancy in the data from 2013 to 2022. Here, we emphasize these features in several cancer types and cell lines using in vitro and in vivo methods.