A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence

Khan, Nadeem Ghani; Correia, Jacinta; Adiga, Divya; Satwadi, Padmalatha Rai; Dsouza, Herman Sunil; Chakrabarty, Sanjiban; Kabekkodu, Shama Prasada

doi:10.1007/s11356-021-13071-w

Cited by 97 publications

(67 citation statements)

References 141 publications

(216 reference statements)

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“…BPA is a chemical used worldwide; however, the exposure varies with regard to the source, environment, time of exposure and age of the organism (27,28). Daily exposure is mostly associated to food and drink containers sold on the market, as well as absorption through the skin or through the maternal placenta or breast milk which are risk factors for the fetus and for the newborn baby (27,29). It exerts an estrogen-like profile but it also induces insulin resistance by impairing peripheral insulin receptors or it decreases insulin secretion by acting on insulin-secreting pancreatic β-cells (27,30).…”

Section: Dm: Past and Futurementioning

confidence: 99%

Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)

et al. 2022

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Various plasticizers and nanomaterials have been linked to endocrine disruptors or endocrine-disrupting chemicals (EDCs) which represent a large, heterogeneous, yet incompletely understood group of structures acting on normal and pathological body pathways such as hormonal production, secretion, transport and receptor binding. By contrast, various applications of nanoparticles are currently under investigation since the delivery of useful drugs, particularly insulin in diabetes mellitus, is essential in case of insulin deficiency. The aim of the present review was to introduce and examine different plasticizers and nanomaterials with potential applications for diabetic patients (such as selenium or gold-based nanoparticles that help the oral delivery of insulin) or plasticizers/nanomaterials acting similarly to EDCs in relation to the human and animal body, particularly glucose metabolism impairment such as diabetes mellitus (DM). Bisphenol A is a chemical used worldwide; however, the effect of exposure varies with regard to the source, environment, time of exposure and the age of the organism. Daily exposure is mostly related to food and drinks stored in polycarbonate plastics. However, exposure may also be through the skin or through the maternal placenta or breast milk which are risk factors for the fetus and for the newborn. It exerts an estrogen-like profile, but it also induces insulin resistance by impairing peripheral insulin receptors or it decreases insulin secretion by acting at the level of insulin-secreting pancreatic β-cells. Phthalates, compounds of flexible plastics, act as EDCs via their human metabolites such as diethyl phthalate and derivative monoethyl phthalate. Their role in inducing gestational DM and weight gain/obesity during pregnancy has been showcased. The vast field of plasticizers and nanomolecules acting as endocrine disruptors is widely linked to clinical aspects of DM, a serious condition with a major population impact. The importance of understanding and using these agents and applications is reflected in saving numerous human lives. Contents 1. Introduction 2. Diabetes mellitus (DM): Past and future 3. Conclusions

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Section: Dm: Past and Futurementioning

confidence: 99%

Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)

et al. 2022

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“…In a randomized trial, the consumption of canned beverages with a BPA-liner resulted in higher urinary BPA concentrations and an acute increase in blood pressure ( Bae and Hong 2015 ). Given its estrogenic properties ( Khan et al. 2021 ), some biological effects of BPA on the CV system are likely mediated by endocrine disruption (KC12), but BPA may also exert its biological effects through multiple other KCs (e.g., KCs 1, 9, 10, and 11), see Table 2 .…”

Section: Examples Of How the Kcs May Produce CV Dysfunction And Diseasementioning

confidence: 99%

Key Characteristics of Cardiovascular Toxicants

Lind¹,

Araujo

Barchowsky

et al. 2021

Environ Health Perspect

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Background: The concept of chemical agents having properties that confer potential hazard called key characteristics (KCs) was first developed to identify carcinogenic hazards. Identification of KCs of cardiovascular (CV) toxicants could facilitate the systematic assessment of CV hazards and understanding of assay and data gaps associated with current approaches. Objectives: We sought to develop a consensus-based synthesis of scientific evidence on the KCs of chemical and nonchemical agents known to cause CV toxicity along with methods to measure them. Methods: An expert working group was convened to discuss mechanisms associated with CV toxicity. Results: The group identified 12 KCs of CV toxicants, defined as exogenous agents that adversely interfere with function of the CV system. The KCs were organized into those primarily affecting cardiac tissue (numbers 1–4 below), the vascular system (5–7), or both (8–12), as follows: 1) impairs regulation of cardiac excitability, 2) impairs cardiac contractility and relaxation, 3) induces cardiomyocyte injury and death, 4) induces proliferation of valve stroma, 5) impacts endothelial and vascular function, 6) alters hemostasis, 7) causes dyslipidemia, 8) impairs mitochondrial function, 9) modifies autonomic nervous system activity, 10) induces oxidative stress, 11) causes inflammation, and 12) alters hormone signaling. Discussion: These 12 KCs can be used to help identify pharmaceuticals and environmental pollutants as CV toxicants, as well as to better understand the mechanistic underpinnings of their toxicity. For example, evidence exists that fine particulate matter [PM in aerodynamic diameter ( )] air pollution, arsenic, anthracycline drugs, and other exogenous chemicals possess one or more of the described KCs. In conclusion, the KCs could be used to identify potential CV toxicants and to define a set of test methods to evaluate CV toxicity in a more comprehensive and standardized manner than current approaches. https://doi.org/10.1289/EHP9321

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“…Apart from genetic changes, exposure to endocrine-disrupting chemicals (EDCs) can disturb the normal functions of the endocrine system in humans and increase the risk of adverse health effects [1]. Bisphenol A (BPA) (an EDC) has a pro-carcinogenic impact in hormone-dependent and hormone-independent cancers [9][10][11]. BPA exposure is reported to alter the cancer cells' biological behaviours, particularly, proliferation, invasion, growth, survival, migration and apoptosis [9,[12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Bisphenol A (BPA) (an EDC) has a pro-carcinogenic impact in hormone-dependent and hormone-independent cancers [9][10][11]. BPA exposure is reported to alter the cancer cells' biological behaviours, particularly, proliferation, invasion, growth, survival, migration and apoptosis [9,[12][13][14][15][16]. Recently, we have identified seven genes that have prognostic power for the overall survival in OC, namely Guanylate Binding Protein 5 (GBP5), Insulin Receptor Substrate 2 (IRS2), Keratin 4 (KRT4), long intergenic non-protein coding RNA 707 (LINC00707), Mitochondrial Ribosomal Protein L55 (MRPL55), Ribosome Biogenesis Regulator 1 Homolog (RRS1) and Solute Carrier Family 4 Member 11 (SLC4A11).…”

Section: Introductionmentioning

confidence: 99%

In Silico Study to Predict the Structural and Functional Consequences of SNPs on Biomarkers of Ovarian Cancer (OC) and BPA Exposure-Associated OC

Zahra

Hall

Chatterjee

et al. 2022

IJMS

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Background: Recently, we have shown that seven genes, namely GBP5, IRS2, KRT4, LINCOO707, MRPL55, RRS1 and SLC4A11, have prognostic power for the overall survival in ovarian cancer (OC). Methods: We present an analysis on the association of these genes with any phenotypes and mutations indicative of involvement in female cancers and predict the structural and functional consequences of those SNPS using in silico tools. Results: These seven genes present with 976 SNPs/mutations that are associated with human cancers, out of which 284 related to female cancers. We have then analysed the mutation impact on amino acid polarity, charge and water affinity, leading to the identification of 30 mutations in gynaecological cancers where amino acid (aa) changes lead to opposite polarity, charges and water affinity. Out of these 30 mutations identified, only a missense mutation (i.e., R831C/R804C in uterine corpus endometrial carcinomas, UCEC) was suggestive of structural damage on the SLC4A11 protein. Conclusions: We demonstrate that the R831C/R804C mutation is deleterious and the predicted ΔΔG values suggest that the mutation reduces the stability of the protein. Future in vitro studies should provide further insight into the role of this transporter protein in UCEC.

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A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence

Cited by 97 publications

References 141 publications

Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)

Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)

Key Characteristics of Cardiovascular Toxicants

In Silico Study to Predict the Structural and Functional Consequences of SNPs on Biomarkers of Ovarian Cancer (OC) and BPA Exposure-Associated OC

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