A comprehensive review on the production, pharmacokinetics and health benefits of mulberry leaf iminosugars: Main focus on 1-deoxynojirimycin, d-fagomine, and 2-O-ɑ-d-galactopyranosyl-DNJ

Parida, Isabella Supardi; Takasu, Soo; Nakagawa, Kiyotaka

doi:10.1080/10408398.2021.1989660

Cited by 16 publications

(9 citation statements)

References 145 publications

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“…7 Kaempferol-3-O-rutinoside, quercetin, morin, coumaric acid, gallic acid, caffeic acid, ferulic acid, and polysaccharides are also present in ML. [8][9][10][11] The bioactive components in ML are mainly divided into flavonoids, [12][13][14] phenolics, 13,15,16 phytosterols, 17,18 terpenes, 17,18 γ-aminobutyric acid, 19,20 alkaloids, [21][22][23] and polysaccharides. [23][24][25][26] 1-DNJ is one of the primary alkaloids in ML, and it is an inhibitor of α-glucosidase, which results in the inhibition of the elevation of postprandial blood glucose.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11] The bioactive components in ML are mainly divided into flavonoids, [12][13][14] phenolics, 13,15,16 phytosterols, 17,18 terpenes, 17,18 γ-aminobutyric acid, 19,20 alkaloids, [21][22][23] and polysaccharides. [23][24][25][26] 1-DNJ is one of the primary alkaloids in ML, and it is an inhibitor of α-glucosidase, which results in the inhibition of the elevation of postprandial blood glucose. 27 Anti-oxidant, anti-inflammatory, anti-inflammatory, and antiobesity effects have been observed after oral administration of 1-DNJ.…”

Section: Introductionmentioning

confidence: 99%

“…36,37 Several reviews have previously been published and focused on the active principles in ML and their functional properties. 3,18,23,28,38,39 However, there has been no meta-analysis on the effect of ML/MLE on glycemic levels in clinical trials. The aim of the present study was to analyze randomized controlled trials (RCTs) and assess evidence of the effects of ML/MLE on fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), and fasting plasma insulin (FPI) in healthy people, diabetics, obese, and other people consuming ML/ MLE as compared with the controls.…”

Section: Introductionmentioning

confidence: 99%

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Effect of mulberry leaf or mulberry leaf extract on glycemic traits: a systematic review and meta-analysis

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of mulberry leaf or mulberry leaf extract on glycemic traits: a systematic review and meta-analysis

et al. 2023

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“…Subsequent research furthermore confirmed that the delay in rate of absorption attributable to MFE is modest (about 10 %), even at a dose two times greater than used here (15) . This may reflect the fact that DNJ itself is highly bioavailable and fairly rapidly absorbed, so its presence and effects on carbohydrate digestion in the gut are of relatively short duration (31) . However, for novel functional ingredients or doses with greater effects on gastrointestinal transit times, or a more sustained presence in the gut, it may be appropriate to focus on the 3-h or even longer post-prandial periods and to include more blood collection time points to capture the response profiles with sufficient resolution.…”

Section: Discussionmentioning

confidence: 99%

Effect of mulberry fruit extract on post-prandial glycaemic and insulinemic responses to different rice types: a randomised trial in healthy adults

et al. 2023

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We previously reported that the addition of a specified mulberry fruit extract (MFE) to rice consistently reduces post-prandial glycemic (PPG) and insulinemic (PPI) responses. This research tested whether this effect generalizes to a broad range of rice types, reflecting the wide variation in rice characteristics known to influence glycemic responses. In a randomized, balanced, partial factorial crossover design, Sona Masoori (SM), Bora Saul (BS), Gobindobogh (Gb), and Banskati (Bn) rices were tested with and without 0.37 g MFE. Healthy, normal weight Indian adults (N = 120) each consumed 4 of the 8 possible boiled rice meals, all containing ∼50 g available carbohydrate. The primary outcome was the effect of MFE on PPG, expressed as the percentage change in the positive, incremental area under the curve over 2 hours. The mean effect of MFE on PPG for all rice types combined was -11.4% (p<0.003). The reduction in PPG was in a qualitatively similar range for all rice types (-9.8 to -15.1%), and this was statistically significant for Bn. MFE also reduced the corresponding PPI response to all rice types combined by a mean of 10.1% (p<0.001; range -6.1 to -13.4%), and the reduction in PPI was statistically significant for SM, Gb and BS. In conclusion, addition of 0.37 g MFE modestly reduced PPG and PPI responses to rices in general, and the effects were statistically significant for specific rice types.

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“…DNJ is a strong α-glycosidase inhibitor, which affects the metabolism of carbohydrates in the small intestine, the secretion of glycoproteins, cell to cell or cell to virus recognition, and other biological processes by inhibiting the activity of glycosidase. 3 ; 22 Thus, exploiting health food and medicine with DNJ as active ingredient has broad application prospects.…”

Section: Biosynthesis Of Alkaloidsmentioning

confidence: 99%

Biosynthetic pathways and related genes regulation of bioactive ingredients in mulberry leaves

Lu,

Zhang,

Tian

et al. 2023

Plant Signaling & Behavior

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Mulberry leaves are served not only as fodder for silkworms but also as potential functional food, exhibiting nutritional and medical benefits due to the complex and diverse constituents, including alkaloids, flavonoids, phenolic acids, and benzofurans, which possess a wide range of biological activities, such as anti-diabete, anti-oxidant, anti-inflammatory, and so on. Nevertheless, compared with the well-studied phytochemistry and pharmacology of mulberry leaves, the current understanding of the biosynthesis mechanisms and regulatory mechanisms of active ingredients in mulberry leaves remain unclear. Natural resources of these active ingredients are limited owing to their low contents in mulberry leaves tissues and the long growth cycle of mulberry. Biosynthesis is emerging as an alternative means for accumulation of the desired high-value compounds, which can broaden channels for their large-scale green productions. Therefore, this review summarizes the recent research advance on the correlative key genes, enzyme biocatalytic reactions and biosynthetic pathways of valuable natural ingredients (i.e. alkaloids, flavonoids, phenolic acids, and benzofurans) in mulberry leaves, thereby offering important insights for their further biomanufacturing.

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A comprehensive review on the production, pharmacokinetics and health benefits of mulberry leaf iminosugars: Main focus on 1-deoxynojirimycin, d-fagomine, and 2-O-ɑ-d-galactopyranosyl-DNJ

Cited by 16 publications

References 145 publications

Effect of mulberry leaf or mulberry leaf extract on glycemic traits: a systematic review and meta-analysis

Effect of mulberry leaf or mulberry leaf extract on glycemic traits: a systematic review and meta-analysis

Effect of mulberry fruit extract on post-prandial glycaemic and insulinemic responses to different rice types: a randomised trial in healthy adults

Biosynthetic pathways and related genes regulation of bioactive ingredients in mulberry leaves

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