A Comprehensive Review on the Potential of Microfabricated Microneedles for Effective Systemic Delivery of Drugs

Abstract

Microneedles are a new technology for percutaneous drug delivery. They are often conveyed in a series of multiple simple microneedles used on the skin to facilitate systemic or topical drug delivery. They are manufactured using various techniques and they could be hollow, solid, coated or polymeric. Although classified as an emerging but expanding field of drug delivery, they are flawed in many ways. This paper will extensively discuss (in the context of skin physiology) the use of microneedles and their feasibility in delivering medication to sites of actions in the body. This paper is a review paper and data were collated from multiple sources including journals and articles. Microneedles show great potential; however, the physiology of the skin poses a great challenge for researches in this field.

Microneedles: Recent advances and development in the field of transdermal drug delivery technology

“…The selection of methods for microneedles fabrication depends solely on the geometry, kinds of microneedles and the type of materials employed for fabrication. The various fabrication techniques are applied for different types of microneedles which are described as follows: 38 . Herein flat metallic sheets are cut using infrared laser to generate 2D shape of micron sized needles and the shape, size and orientation of microneedles array are designed using computer aided software (Auto CAD).…”