A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part I. Theoretical material

Ducros, Nicolas; Hervé, Lionel; Silva, Anabela Da; Dinten, Jean‐Marc; Peyrin, Françoise

doi:10.1088/0031-9155/54/23/004

Cited by 21 publications

(18 citation statements)

References 57 publications

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“…However, even these higher moments still have significant contribution from early-arriving photons [11]. Binning methods applied to DTOFs can be used to isolate photons with longer arrival times, but this approach is prone to signal-to-noise (SNR) limitations and requires careful measurement of the instrument response function (IRF) [8,[12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Subtraction-based approach for enhancing the depth sensitivity of time-resolved NIRS

Milej

Abdalmalak

McLachlan

et al. 2016

Biomed. Opt. Express

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The aim of this study was to evaluate enhancing of the depth sensitivity of timeresolved near-infrared spectroscopy with a subtraction-based approach. Due to the complexity of light propagation in a heterogeneous media, and to prove the validity of the proposed method in a heterogeneous turbid media we conducted a broad analysis taking into account a number of parameters related to the method as well as various parameters of this media. The results of these experiments confirm that the depth sensitivity of the subtraction-based approach is better than classical approaches using continuous-wave or time-resolved methods. Furthermore, the results showed that the subtraction-based approach has a unique, selective sensitivity to a layer at a specific depth. In vivo application of the proposed method resulted in a greater magnitude of the hemodynamic changes during functional activation than with the standard approach.

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Section: Introductionmentioning

confidence: 99%

Subtraction-based approach for enhancing the depth sensitivity of time-resolved NIRS

Milej

Abdalmalak

McLachlan

et al. 2016

Biomed. Opt. Express

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“…[10][11][12][13]17 Specifically, the Laplace transform of the TR signals 12 and above all the temporal moments of the fluorescence signals have been intensively studied and employed. 10,11,13,18,19 The moment approach is of particular interest since it allows for a physical interpretation of the features, in terms of the number of photons and their time of flight, while being easy to calculate. 20 The moment approach is the most studied one and is therefore often recognized as the gold standard.…”

Section: Introductionmentioning

confidence: 99%

A time‐domain wavelet‐based approach for fluorescence diffuse optical tomography

et al. 2010

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Purpose: In the context of fluorescence diffuse optical tomography, determining the optimal way to exploit the time-resolved information has been receiving much attention and different features of the time-resolved signals have been introduced. In this article, the authors revisit and generalize the notion of feature, considering the projection of the measurements onto some basis functions. This leads the authors to propose a novel approach based on the wavelet transform of the measurements. Methods: A comparative study between the reconstructions obtained from the proposed waveletbased approach and the reconstructions obtained from the reference temporal moments is provided. An inhomogeneous cubic medium is considered. Reconstructions are performed from synthetic measurements assuming Poisson noise statistics. In order to provide fairly comparable reconstructions, the reconstruction scheme is associated with a particular procedure for selecting the regularization parameter. Results: In the noise-free case, the reconstruction quality is shown to be mainly driven by the number of selected features. In the presence of noise, however, the reconstruction quality depends on the type of the features. In this case, the wavelet approach is shown to outperform the moment approach. While the optimal time-resolved reconstruction quality, which is obtained considering the whole set of time samples, is recovered using only eight wavelet functions, it cannot be attained using moments. It is finally observed that the time-resolved information is of limited utility, in terms of reconstruction, when the maximum number of detected photons is lower than 10 5 . Conclusions: The wavelet approach allows for better exploiting the time-resolved information, especially when the number of detected photons is low. However, when the number of detected photons decreases below a certain threshold, the time-resolved information itself is shown to be of limited utility.

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“…To enable comparison between solutions obtained from different system matrix A and measurement vector y, the regularization parameter is chosen so as to set the variability of the solution to a prescribed value, i.e., few percents (details are provided in [19]). …”

Section: Inverse Problemmentioning

confidence: 99%

“…Frequency-domain (FD) FDOT is based on the measurement of the phase and demodulation of an amplitude-modulated excitation [13]. Time-resolved (TR) FDOT exploits the measurement of the temporal distortion of an excitation light pulse [14][15][16][17][18][19][20]. FD and TR provide significant advantages with respect to CW approach.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence diffuse optical tomography: Time-resolved versus continuous-wave in the reflectance configuration

Ducros

D’Andrea

Bassi

et al. 2011

IRBM

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International audienceContext and objectives In the context of fluorescence diffuse optical tomography, the time-resolved approach was shown to improve the reconstruction quality compared to the continuous-wave approach when adopting the transmittance configuration. However, the improvement seriously decreases in the presence of noise. The scope of this paper is to investigate the additional value of the time-resolved approach in the reflectance configuration. Material and methods A comparative study between time-resolved and continuous-wave reconstructions is provided in the reflectance configuration. Reconstructions are performed from synthetic measurements in a slab geometry assuming Poisson noise statistics. Results and discussion In the reflectance configuration, the reconstruction quality, expressed in terms of the global reconstruction error or in terms of the localization and quantification of a local inclusion, is shown to be sensibly higher when the time-resolved approach is considered rather than the continuous-wave one. This behavior is observed for which the maximum number of detected photons is around 106. Conclusion In the reflectance configuration, considering realistic level of signal the time-resolved approach is shown to outperform continuous-wave approach

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A comprehensive study of the use of temporal moments in time-resolved diffuse optical tomography: part I. Theoretical material

Cited by 21 publications

References 57 publications

Subtraction-based approach for enhancing the depth sensitivity of time-resolved NIRS

Subtraction-based approach for enhancing the depth sensitivity of time-resolved NIRS

A time‐domain wavelet‐based approach for fluorescence diffuse optical tomography

Fluorescence diffuse optical tomography: Time-resolved versus continuous-wave in the reflectance configuration

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